Neurological sequelae of healthcare-associated sepsis in very-low-birthweight infants: Umbrella review and evidence-based outcome tree
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Neurological sequelae of healthcare-associated sepsis in very-low-birthweight infants: Umbrella review and evidence-based outcome tree. / Haller, Sebastian; Deindl, Philipp; Cassini, Alessandro; Suetens, Carl; Zingg, Walter; Abu Sin, Muna; Velasco, Edward; Weiss, Bettina; Ducomble, Tanja; Sixtensson, Madlen; Eckmanns, Tim; Harder, Thomas.
In: EUROSURVEILLANCE, Vol. 21, No. 8, 2016, p. 11-20.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Neurological sequelae of healthcare-associated sepsis in very-low-birthweight infants: Umbrella review and evidence-based outcome tree
AU - Haller, Sebastian
AU - Deindl, Philipp
AU - Cassini, Alessandro
AU - Suetens, Carl
AU - Zingg, Walter
AU - Abu Sin, Muna
AU - Velasco, Edward
AU - Weiss, Bettina
AU - Ducomble, Tanja
AU - Sixtensson, Madlen
AU - Eckmanns, Tim
AU - Harder, Thomas
PY - 2016
Y1 - 2016
N2 - Sepsis is a frequent cause of death in very-low-birthweight infants and often results in neurological impairment. Its attributable risk of sequelae has not been systematically assessed. To establish an outcome tree for mapping the burden of neonatal sepsis, we performed systematic literature searches to identify systematic reviews addressing sequelae of neonatal sepsis. We included cohort studies and performed meta-analyses of attributable risks. Evidence quality was assessed using GRADE. Two systematic reviews met inclusion criteria. The first included nine cohort studies with 5,620 participants and five outcomes (neurodevelopmental impairment, cerebral palsy, vision impairment, hearing impairment, death). Pooled risk differences varied between 4% (95% confidence interval (CI):2-10) and 13% (95% CI:5-20). From the second review we analysed four studies with 472 infants. Positive predictive value of neurodevelopmental impairment for later cognitive impairment ranged between 67% (95% CI:22-96) and 83% (95% CI:36-100). Neonatal sepsis increases risk of permanent neurological impairment. Effect size varies by outcome, with evidence quality being low to very low. Data were used to construct an outcome tree for neonatal sepsis. Attributable risk estimates for sequelae following neonatal sepsis are suitable for burden estimation and may serve as outcome parameters in interventional studies.
AB - Sepsis is a frequent cause of death in very-low-birthweight infants and often results in neurological impairment. Its attributable risk of sequelae has not been systematically assessed. To establish an outcome tree for mapping the burden of neonatal sepsis, we performed systematic literature searches to identify systematic reviews addressing sequelae of neonatal sepsis. We included cohort studies and performed meta-analyses of attributable risks. Evidence quality was assessed using GRADE. Two systematic reviews met inclusion criteria. The first included nine cohort studies with 5,620 participants and five outcomes (neurodevelopmental impairment, cerebral palsy, vision impairment, hearing impairment, death). Pooled risk differences varied between 4% (95% confidence interval (CI):2-10) and 13% (95% CI:5-20). From the second review we analysed four studies with 472 infants. Positive predictive value of neurodevelopmental impairment for later cognitive impairment ranged between 67% (95% CI:22-96) and 83% (95% CI:36-100). Neonatal sepsis increases risk of permanent neurological impairment. Effect size varies by outcome, with evidence quality being low to very low. Data were used to construct an outcome tree for neonatal sepsis. Attributable risk estimates for sequelae following neonatal sepsis are suitable for burden estimation and may serve as outcome parameters in interventional studies.
KW - Cerebral Palsy
KW - Child Development
KW - Cross Infection
KW - Developmental Disabilities
KW - Female
KW - Humans
KW - Infant, Newborn
KW - Infant, Very Low Birth Weight
KW - Male
KW - Neurodevelopmental Disorders
KW - Quality-Adjusted Life Years
KW - Sepsis
KW - Journal Article
KW - Review
U2 - 10.2807/1560-7917.ES.2016.21.8.30143
DO - 10.2807/1560-7917.ES.2016.21.8.30143
M3 - SCORING: Journal article
C2 - 26940884
VL - 21
SP - 11
EP - 20
JO - EUROSURVEILLANCE
JF - EUROSURVEILLANCE
SN - 1025-496X
IS - 8
ER -