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Neurological sequelae of healthcare-associated sepsis in very-low-birthweight infants: Umbrella review and evidence-based outcome tree

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Neurological sequelae of healthcare-associated sepsis in very-low-birthweight infants: Umbrella review and evidence-based outcome tree. / Haller, Sebastian; Deindl, Philipp; Cassini, Alessandro; Suetens, Carl; Zingg, Walter; Abu Sin, Muna; Velasco, Edward; Weiss, Bettina; Ducomble, Tanja; Sixtensson, Madlen; Eckmanns, Tim; Harder, Thomas.

in: EUROSURVEILLANCE, Jahrgang 21, Nr. 8, 2016, S. 11-20.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Haller, S, Deindl, P, Cassini, A, Suetens, C, Zingg, W, Abu Sin, M, Velasco, E, Weiss, B, Ducomble, T, Sixtensson, M, Eckmanns, T & Harder, T 2016, 'Neurological sequelae of healthcare-associated sepsis in very-low-birthweight infants: Umbrella review and evidence-based outcome tree', EUROSURVEILLANCE, Jg. 21, Nr. 8, S. 11-20. https://doi.org/10.2807/1560-7917.ES.2016.21.8.30143

APA

Haller, S., Deindl, P., Cassini, A., Suetens, C., Zingg, W., Abu Sin, M., Velasco, E., Weiss, B., Ducomble, T., Sixtensson, M., Eckmanns, T., & Harder, T. (2016). Neurological sequelae of healthcare-associated sepsis in very-low-birthweight infants: Umbrella review and evidence-based outcome tree. EUROSURVEILLANCE, 21(8), 11-20. https://doi.org/10.2807/1560-7917.ES.2016.21.8.30143

Vancouver

Haller S, Deindl P, Cassini A, Suetens C, Zingg W, Abu Sin M et al. Neurological sequelae of healthcare-associated sepsis in very-low-birthweight infants: Umbrella review and evidence-based outcome tree. EUROSURVEILLANCE. 2016;21(8):11-20. https://doi.org/10.2807/1560-7917.ES.2016.21.8.30143

Bibtex

@article{e649f41936ba467295fb9f183f743253,
title = "Neurological sequelae of healthcare-associated sepsis in very-low-birthweight infants: Umbrella review and evidence-based outcome tree",
abstract = "Sepsis is a frequent cause of death in very-low-birthweight infants and often results in neurological impairment. Its attributable risk of sequelae has not been systematically assessed. To establish an outcome tree for mapping the burden of neonatal sepsis, we performed systematic literature searches to identify systematic reviews addressing sequelae of neonatal sepsis. We included cohort studies and performed meta-analyses of attributable risks. Evidence quality was assessed using GRADE. Two systematic reviews met inclusion criteria. The first included nine cohort studies with 5,620 participants and five outcomes (neurodevelopmental impairment, cerebral palsy, vision impairment, hearing impairment, death). Pooled risk differences varied between 4% (95% confidence interval (CI):2-10) and 13% (95% CI:5-20). From the second review we analysed four studies with 472 infants. Positive predictive value of neurodevelopmental impairment for later cognitive impairment ranged between 67% (95% CI:22-96) and 83% (95% CI:36-100). Neonatal sepsis increases risk of permanent neurological impairment. Effect size varies by outcome, with evidence quality being low to very low. Data were used to construct an outcome tree for neonatal sepsis. Attributable risk estimates for sequelae following neonatal sepsis are suitable for burden estimation and may serve as outcome parameters in interventional studies.",
keywords = "Cerebral Palsy, Child Development, Cross Infection, Developmental Disabilities, Female, Humans, Infant, Newborn, Infant, Very Low Birth Weight, Male, Neurodevelopmental Disorders, Quality-Adjusted Life Years, Sepsis, Journal Article, Review",
author = "Sebastian Haller and Philipp Deindl and Alessandro Cassini and Carl Suetens and Walter Zingg and {Abu Sin}, Muna and Edward Velasco and Bettina Weiss and Tanja Ducomble and Madlen Sixtensson and Tim Eckmanns and Thomas Harder",
year = "2016",
doi = "10.2807/1560-7917.ES.2016.21.8.30143",
language = "English",
volume = "21",
pages = "11--20",
journal = "EUROSURVEILLANCE",
issn = "1025-496X",
publisher = "Centre Europeen pour la Surveillance Epidemiologique du SIDA",
number = "8",

}

RIS

TY - JOUR

T1 - Neurological sequelae of healthcare-associated sepsis in very-low-birthweight infants: Umbrella review and evidence-based outcome tree

AU - Haller, Sebastian

AU - Deindl, Philipp

AU - Cassini, Alessandro

AU - Suetens, Carl

AU - Zingg, Walter

AU - Abu Sin, Muna

AU - Velasco, Edward

AU - Weiss, Bettina

AU - Ducomble, Tanja

AU - Sixtensson, Madlen

AU - Eckmanns, Tim

AU - Harder, Thomas

PY - 2016

Y1 - 2016

N2 - Sepsis is a frequent cause of death in very-low-birthweight infants and often results in neurological impairment. Its attributable risk of sequelae has not been systematically assessed. To establish an outcome tree for mapping the burden of neonatal sepsis, we performed systematic literature searches to identify systematic reviews addressing sequelae of neonatal sepsis. We included cohort studies and performed meta-analyses of attributable risks. Evidence quality was assessed using GRADE. Two systematic reviews met inclusion criteria. The first included nine cohort studies with 5,620 participants and five outcomes (neurodevelopmental impairment, cerebral palsy, vision impairment, hearing impairment, death). Pooled risk differences varied between 4% (95% confidence interval (CI):2-10) and 13% (95% CI:5-20). From the second review we analysed four studies with 472 infants. Positive predictive value of neurodevelopmental impairment for later cognitive impairment ranged between 67% (95% CI:22-96) and 83% (95% CI:36-100). Neonatal sepsis increases risk of permanent neurological impairment. Effect size varies by outcome, with evidence quality being low to very low. Data were used to construct an outcome tree for neonatal sepsis. Attributable risk estimates for sequelae following neonatal sepsis are suitable for burden estimation and may serve as outcome parameters in interventional studies.

AB - Sepsis is a frequent cause of death in very-low-birthweight infants and often results in neurological impairment. Its attributable risk of sequelae has not been systematically assessed. To establish an outcome tree for mapping the burden of neonatal sepsis, we performed systematic literature searches to identify systematic reviews addressing sequelae of neonatal sepsis. We included cohort studies and performed meta-analyses of attributable risks. Evidence quality was assessed using GRADE. Two systematic reviews met inclusion criteria. The first included nine cohort studies with 5,620 participants and five outcomes (neurodevelopmental impairment, cerebral palsy, vision impairment, hearing impairment, death). Pooled risk differences varied between 4% (95% confidence interval (CI):2-10) and 13% (95% CI:5-20). From the second review we analysed four studies with 472 infants. Positive predictive value of neurodevelopmental impairment for later cognitive impairment ranged between 67% (95% CI:22-96) and 83% (95% CI:36-100). Neonatal sepsis increases risk of permanent neurological impairment. Effect size varies by outcome, with evidence quality being low to very low. Data were used to construct an outcome tree for neonatal sepsis. Attributable risk estimates for sequelae following neonatal sepsis are suitable for burden estimation and may serve as outcome parameters in interventional studies.

KW - Cerebral Palsy

KW - Child Development

KW - Cross Infection

KW - Developmental Disabilities

KW - Female

KW - Humans

KW - Infant, Newborn

KW - Infant, Very Low Birth Weight

KW - Male

KW - Neurodevelopmental Disorders

KW - Quality-Adjusted Life Years

KW - Sepsis

KW - Journal Article

KW - Review

U2 - 10.2807/1560-7917.ES.2016.21.8.30143

DO - 10.2807/1560-7917.ES.2016.21.8.30143

M3 - SCORING: Journal article

C2 - 26940884

VL - 21

SP - 11

EP - 20

JO - EUROSURVEILLANCE

JF - EUROSURVEILLANCE

SN - 1025-496X

IS - 8

ER -