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Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms.

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Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms. / Haworth, Robert S; Stathopoulou, Konstantina; Candasamy, Alexandra J; Avkiran, Metin.

In: CIRC RES, Vol. 110, No. 12, 12, 2012, p. 1585-1595.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Haworth, RS, Stathopoulou, K, Candasamy, AJ & Avkiran, M 2012, 'Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms.', CIRC RES, vol. 110, no. 12, 12, pp. 1585-1595. <http://www.ncbi.nlm.nih.gov/pubmed/22581927?dopt=Citation>

APA

Haworth, R. S., Stathopoulou, K., Candasamy, A. J., & Avkiran, M. (2012). Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms. CIRC RES, 110(12), 1585-1595. [12]. http://www.ncbi.nlm.nih.gov/pubmed/22581927?dopt=Citation

Vancouver

Haworth RS, Stathopoulou K, Candasamy AJ, Avkiran M. Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms. CIRC RES. 2012;110(12):1585-1595. 12.

Bibtex

@article{2bd608309a5d42b9a0c48ba3c2e6ae5b,
title = "Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms.",
abstract = "Myocyte enhancer factor 2 (MEF2) transcription factors drive the genetic reprogramming that precipitates pathological cardiac hypertrophy and remodeling. Class II histone deacetylase (HDAC) isoforms, such as HDAC5, act as signal-responsive repressors of MEF2 activity in cardiac myocytes and their nuclear export provides a key mechanism for the neurohormonal induction of such activity.",
keywords = "Animals, Cells, Cultured, Rats, Active Transport, Cell Nucleus/physiology, Cell Nucleus/enzymology/*metabolism, Histone Deacetylases/*metabolism, Myocytes, Cardiac/enzymology/*metabolism, Neurotransmitter Agents/*physiology, Phosphorylation/physiology, Animals, Cells, Cultured, Rats, Active Transport, Cell Nucleus/physiology, Cell Nucleus/enzymology/*metabolism, Histone Deacetylases/*metabolism, Myocytes, Cardiac/enzymology/*metabolism, Neurotransmitter Agents/*physiology, Phosphorylation/physiology",
author = "Haworth, {Robert S} and Konstantina Stathopoulou and Candasamy, {Alexandra J} and Metin Avkiran",
year = "2012",
language = "English",
volume = "110",
pages = "1585--1595",
journal = "CIRC RES",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

RIS

TY - JOUR

T1 - Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms.

AU - Haworth, Robert S

AU - Stathopoulou, Konstantina

AU - Candasamy, Alexandra J

AU - Avkiran, Metin

PY - 2012

Y1 - 2012

N2 - Myocyte enhancer factor 2 (MEF2) transcription factors drive the genetic reprogramming that precipitates pathological cardiac hypertrophy and remodeling. Class II histone deacetylase (HDAC) isoforms, such as HDAC5, act as signal-responsive repressors of MEF2 activity in cardiac myocytes and their nuclear export provides a key mechanism for the neurohormonal induction of such activity.

AB - Myocyte enhancer factor 2 (MEF2) transcription factors drive the genetic reprogramming that precipitates pathological cardiac hypertrophy and remodeling. Class II histone deacetylase (HDAC) isoforms, such as HDAC5, act as signal-responsive repressors of MEF2 activity in cardiac myocytes and their nuclear export provides a key mechanism for the neurohormonal induction of such activity.

KW - Animals

KW - Cells, Cultured

KW - Rats

KW - Active Transport, Cell Nucleus/physiology

KW - Cell Nucleus/enzymology/metabolism

KW - Histone Deacetylases/metabolism

KW - Myocytes, Cardiac/enzymology/metabolism

KW - Neurotransmitter Agents/physiology

KW - Phosphorylation/physiology

KW - Animals

KW - Cells, Cultured

KW - Rats

KW - Active Transport, Cell Nucleus/physiology

KW - Cell Nucleus/enzymology/metabolism

KW - Histone Deacetylases/metabolism

KW - Myocytes, Cardiac/enzymology/metabolism

KW - Neurotransmitter Agents/physiology

KW - Phosphorylation/physiology

M3 - SCORING: Journal article

VL - 110

SP - 1585

EP - 1595

JO - CIRC RES

JF - CIRC RES

SN - 0009-7330

IS - 12

M1 - 12

ER -