Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms.
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Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms. / Haworth, Robert S; Stathopoulou, Konstantina; Candasamy, Alexandra J; Avkiran, Metin.
in: CIRC RES, Jahrgang 110, Nr. 12, 12, 2012, S. 1585-1595.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms.
AU - Haworth, Robert S
AU - Stathopoulou, Konstantina
AU - Candasamy, Alexandra J
AU - Avkiran, Metin
PY - 2012
Y1 - 2012
N2 - Myocyte enhancer factor 2 (MEF2) transcription factors drive the genetic reprogramming that precipitates pathological cardiac hypertrophy and remodeling. Class II histone deacetylase (HDAC) isoforms, such as HDAC5, act as signal-responsive repressors of MEF2 activity in cardiac myocytes and their nuclear export provides a key mechanism for the neurohormonal induction of such activity.
AB - Myocyte enhancer factor 2 (MEF2) transcription factors drive the genetic reprogramming that precipitates pathological cardiac hypertrophy and remodeling. Class II histone deacetylase (HDAC) isoforms, such as HDAC5, act as signal-responsive repressors of MEF2 activity in cardiac myocytes and their nuclear export provides a key mechanism for the neurohormonal induction of such activity.
KW - Animals
KW - Cells, Cultured
KW - Rats
KW - Active Transport, Cell Nucleus/physiology
KW - Cell Nucleus/enzymology/metabolism
KW - Histone Deacetylases/metabolism
KW - Myocytes, Cardiac/enzymology/metabolism
KW - Neurotransmitter Agents/physiology
KW - Phosphorylation/physiology
KW - Animals
KW - Cells, Cultured
KW - Rats
KW - Active Transport, Cell Nucleus/physiology
KW - Cell Nucleus/enzymology/metabolism
KW - Histone Deacetylases/metabolism
KW - Myocytes, Cardiac/enzymology/metabolism
KW - Neurotransmitter Agents/physiology
KW - Phosphorylation/physiology
M3 - SCORING: Journal article
VL - 110
SP - 1585
EP - 1595
JO - CIRC RES
JF - CIRC RES
SN - 0009-7330
IS - 12
M1 - 12
ER -