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Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior

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Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior. / Wagner, Michael; Schulze-Rauschenbach, Svenja; Petrovsky, Nadine; Brinkmeyer, Juergen; von der Goltz, Christoph; Gründer, Gerd; Spreckelmeyer, Katja N; Wienker, Thomas; Diaz-Lacava, Amalia; Mobascher, Arian; Dahmen, Norbert; Clepce, Marion; Thuerauf, Norbert; Kiefer, Falk; de Millas, J Walter; Gallinat, Jürgen; Winterer, Georg.

In: ADDICT BIOL, Vol. 18, No. 4, 01.07.2013, p. 752-61.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wagner, M, Schulze-Rauschenbach, S, Petrovsky, N, Brinkmeyer, J, von der Goltz, C, Gründer, G, Spreckelmeyer, KN, Wienker, T, Diaz-Lacava, A, Mobascher, A, Dahmen, N, Clepce, M, Thuerauf, N, Kiefer, F, de Millas, JW, Gallinat, J & Winterer, G 2013, 'Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior', ADDICT BIOL, vol. 18, no. 4, pp. 752-61. https://doi.org/10.1111/j.1369-1600.2011.00429.x

APA

Wagner, M., Schulze-Rauschenbach, S., Petrovsky, N., Brinkmeyer, J., von der Goltz, C., Gründer, G., Spreckelmeyer, K. N., Wienker, T., Diaz-Lacava, A., Mobascher, A., Dahmen, N., Clepce, M., Thuerauf, N., Kiefer, F., de Millas, J. W., Gallinat, J., & Winterer, G. (2013). Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior. ADDICT BIOL, 18(4), 752-61. https://doi.org/10.1111/j.1369-1600.2011.00429.x

Vancouver

Wagner M, Schulze-Rauschenbach S, Petrovsky N, Brinkmeyer J, von der Goltz C, Gründer G et al. Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior. ADDICT BIOL. 2013 Jul 1;18(4):752-61. https://doi.org/10.1111/j.1369-1600.2011.00429.x

Bibtex

@article{9b8e9cae054945fb8bfc28d417abad04,
title = "Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior",
abstract = "The aim of the present study was to examine neurocognitive function associated with chronic nicotine use. A total of 2163 healthy participants (1002 smokers, 1161 never-smoking controls) participated in a population-based case-control design. The main outcome measures were six cognitive domain factors derived from a neuropsychological test battery. In smokers, the battery was administered after controlled smoking of one cigarette. Analyses included age, sex and education as covariates. Results demonstrated small, but significant deficits in smokers for visual attention (P<0.001) and cognitive impulsivity (P<0.006), while verbal episodic memory, verbal fluency, verbal working memory, and Stroop-interference did not differ between groups. These attention/impulsivity deficits were also present in smokers with only a low amount of cigarette consumption. Lifetime nicotine use (pack-years) was not correlated with cognition in smokers. In conclusion, this study confirmed subtle and specific cognitive deficits in non-deprived smokers. The independence of these deficits from consumption intensity may argue for an a priori deficit of some cognitive abilities in smokers. These specific deficits may constitute intermediate phenotypes for genetic research on nicotine use.",
keywords = "Adolescent, Adult, Aged, Alcohol Drinking, Attention, Case-Control Studies, Cognition, Endophenotypes, Female, Genetic Predisposition to Disease, Germany, Humans, Impulsive Behavior, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Nicotine, Principal Component Analysis, Reaction Time, Smoking, Tobacco Use Disorder, Verbal Learning, Young Adult",
author = "Michael Wagner and Svenja Schulze-Rauschenbach and Nadine Petrovsky and Juergen Brinkmeyer and {von der Goltz}, Christoph and Gerd Gr{\"u}nder and Spreckelmeyer, {Katja N} and Thomas Wienker and Amalia Diaz-Lacava and Arian Mobascher and Norbert Dahmen and Marion Clepce and Norbert Thuerauf and Falk Kiefer and {de Millas}, {J Walter} and J{\"u}rgen Gallinat and Georg Winterer",
note = "{\textcopyright} 2012 The Authors, Addiction Biology {\textcopyright} 2012 Society for the Study of Addiction.",
year = "2013",
month = jul,
day = "1",
doi = "10.1111/j.1369-1600.2011.00429.x",
language = "English",
volume = "18",
pages = "752--61",
journal = "ADDICT BIOL",
issn = "1355-6215",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior

AU - Wagner, Michael

AU - Schulze-Rauschenbach, Svenja

AU - Petrovsky, Nadine

AU - Brinkmeyer, Juergen

AU - von der Goltz, Christoph

AU - Gründer, Gerd

AU - Spreckelmeyer, Katja N

AU - Wienker, Thomas

AU - Diaz-Lacava, Amalia

AU - Mobascher, Arian

AU - Dahmen, Norbert

AU - Clepce, Marion

AU - Thuerauf, Norbert

AU - Kiefer, Falk

AU - de Millas, J Walter

AU - Gallinat, Jürgen

AU - Winterer, Georg

N1 - © 2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction.

PY - 2013/7/1

Y1 - 2013/7/1

N2 - The aim of the present study was to examine neurocognitive function associated with chronic nicotine use. A total of 2163 healthy participants (1002 smokers, 1161 never-smoking controls) participated in a population-based case-control design. The main outcome measures were six cognitive domain factors derived from a neuropsychological test battery. In smokers, the battery was administered after controlled smoking of one cigarette. Analyses included age, sex and education as covariates. Results demonstrated small, but significant deficits in smokers for visual attention (P<0.001) and cognitive impulsivity (P<0.006), while verbal episodic memory, verbal fluency, verbal working memory, and Stroop-interference did not differ between groups. These attention/impulsivity deficits were also present in smokers with only a low amount of cigarette consumption. Lifetime nicotine use (pack-years) was not correlated with cognition in smokers. In conclusion, this study confirmed subtle and specific cognitive deficits in non-deprived smokers. The independence of these deficits from consumption intensity may argue for an a priori deficit of some cognitive abilities in smokers. These specific deficits may constitute intermediate phenotypes for genetic research on nicotine use.

AB - The aim of the present study was to examine neurocognitive function associated with chronic nicotine use. A total of 2163 healthy participants (1002 smokers, 1161 never-smoking controls) participated in a population-based case-control design. The main outcome measures were six cognitive domain factors derived from a neuropsychological test battery. In smokers, the battery was administered after controlled smoking of one cigarette. Analyses included age, sex and education as covariates. Results demonstrated small, but significant deficits in smokers for visual attention (P<0.001) and cognitive impulsivity (P<0.006), while verbal episodic memory, verbal fluency, verbal working memory, and Stroop-interference did not differ between groups. These attention/impulsivity deficits were also present in smokers with only a low amount of cigarette consumption. Lifetime nicotine use (pack-years) was not correlated with cognition in smokers. In conclusion, this study confirmed subtle and specific cognitive deficits in non-deprived smokers. The independence of these deficits from consumption intensity may argue for an a priori deficit of some cognitive abilities in smokers. These specific deficits may constitute intermediate phenotypes for genetic research on nicotine use.

KW - Adolescent

KW - Adult

KW - Aged

KW - Alcohol Drinking

KW - Attention

KW - Case-Control Studies

KW - Cognition

KW - Endophenotypes

KW - Female

KW - Genetic Predisposition to Disease

KW - Germany

KW - Humans

KW - Impulsive Behavior

KW - Male

KW - Memory, Short-Term

KW - Middle Aged

KW - Neuropsychological Tests

KW - Nicotine

KW - Principal Component Analysis

KW - Reaction Time

KW - Smoking

KW - Tobacco Use Disorder

KW - Verbal Learning

KW - Young Adult

U2 - 10.1111/j.1369-1600.2011.00429.x

DO - 10.1111/j.1369-1600.2011.00429.x

M3 - SCORING: Journal article

C2 - 22339903

VL - 18

SP - 752

EP - 761

JO - ADDICT BIOL

JF - ADDICT BIOL

SN - 1355-6215

IS - 4

ER -