Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior
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Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior. / Wagner, Michael; Schulze-Rauschenbach, Svenja; Petrovsky, Nadine; Brinkmeyer, Juergen; von der Goltz, Christoph; Gründer, Gerd; Spreckelmeyer, Katja N; Wienker, Thomas; Diaz-Lacava, Amalia; Mobascher, Arian; Dahmen, Norbert; Clepce, Marion; Thuerauf, Norbert; Kiefer, Falk; de Millas, J Walter; Gallinat, Jürgen; Winterer, Georg.
in: ADDICT BIOL, Jahrgang 18, Nr. 4, 01.07.2013, S. 752-61.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior
AU - Wagner, Michael
AU - Schulze-Rauschenbach, Svenja
AU - Petrovsky, Nadine
AU - Brinkmeyer, Juergen
AU - von der Goltz, Christoph
AU - Gründer, Gerd
AU - Spreckelmeyer, Katja N
AU - Wienker, Thomas
AU - Diaz-Lacava, Amalia
AU - Mobascher, Arian
AU - Dahmen, Norbert
AU - Clepce, Marion
AU - Thuerauf, Norbert
AU - Kiefer, Falk
AU - de Millas, J Walter
AU - Gallinat, Jürgen
AU - Winterer, Georg
N1 - © 2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction.
PY - 2013/7/1
Y1 - 2013/7/1
N2 - The aim of the present study was to examine neurocognitive function associated with chronic nicotine use. A total of 2163 healthy participants (1002 smokers, 1161 never-smoking controls) participated in a population-based case-control design. The main outcome measures were six cognitive domain factors derived from a neuropsychological test battery. In smokers, the battery was administered after controlled smoking of one cigarette. Analyses included age, sex and education as covariates. Results demonstrated small, but significant deficits in smokers for visual attention (P<0.001) and cognitive impulsivity (P<0.006), while verbal episodic memory, verbal fluency, verbal working memory, and Stroop-interference did not differ between groups. These attention/impulsivity deficits were also present in smokers with only a low amount of cigarette consumption. Lifetime nicotine use (pack-years) was not correlated with cognition in smokers. In conclusion, this study confirmed subtle and specific cognitive deficits in non-deprived smokers. The independence of these deficits from consumption intensity may argue for an a priori deficit of some cognitive abilities in smokers. These specific deficits may constitute intermediate phenotypes for genetic research on nicotine use.
AB - The aim of the present study was to examine neurocognitive function associated with chronic nicotine use. A total of 2163 healthy participants (1002 smokers, 1161 never-smoking controls) participated in a population-based case-control design. The main outcome measures were six cognitive domain factors derived from a neuropsychological test battery. In smokers, the battery was administered after controlled smoking of one cigarette. Analyses included age, sex and education as covariates. Results demonstrated small, but significant deficits in smokers for visual attention (P<0.001) and cognitive impulsivity (P<0.006), while verbal episodic memory, verbal fluency, verbal working memory, and Stroop-interference did not differ between groups. These attention/impulsivity deficits were also present in smokers with only a low amount of cigarette consumption. Lifetime nicotine use (pack-years) was not correlated with cognition in smokers. In conclusion, this study confirmed subtle and specific cognitive deficits in non-deprived smokers. The independence of these deficits from consumption intensity may argue for an a priori deficit of some cognitive abilities in smokers. These specific deficits may constitute intermediate phenotypes for genetic research on nicotine use.
KW - Adolescent
KW - Adult
KW - Aged
KW - Alcohol Drinking
KW - Attention
KW - Case-Control Studies
KW - Cognition
KW - Endophenotypes
KW - Female
KW - Genetic Predisposition to Disease
KW - Germany
KW - Humans
KW - Impulsive Behavior
KW - Male
KW - Memory, Short-Term
KW - Middle Aged
KW - Neuropsychological Tests
KW - Nicotine
KW - Principal Component Analysis
KW - Reaction Time
KW - Smoking
KW - Tobacco Use Disorder
KW - Verbal Learning
KW - Young Adult
U2 - 10.1111/j.1369-1600.2011.00429.x
DO - 10.1111/j.1369-1600.2011.00429.x
M3 - SCORING: Journal article
C2 - 22339903
VL - 18
SP - 752
EP - 761
JO - ADDICT BIOL
JF - ADDICT BIOL
SN - 1355-6215
IS - 4
ER -