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Neurobehavioural characterisation and stratification of reinforcement-related behaviour

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Neurobehavioural characterisation and stratification of reinforcement-related behaviour. / Jia, Tianye; Ing, Alex; Quinlan, Erin Burke; Tay, Nicole; Luo, Qiang; Francesca, Biondo; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Desrivières, Sylvane; Feng, Jianfeng; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Schumann, Gunter; IMAGEN Consortium.

In: NAT HUM BEHAV, Vol. 4, No. 5, 05.2020, p. 544-558.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jia, T, Ing, A, Quinlan, EB, Tay, N, Luo, Q, Francesca, B, Banaschewski, T, Barker, GJ, Bokde, ALW, Bromberg, U, Büchel, C, Desrivières, S, Feng, J, Flor, H, Grigis, A, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Martinot, J-L, Martinot, M-LP, Nees, F, Orfanos, DP, Paus, T, Poustka, L, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R, Schumann, G & IMAGEN Consortium 2020, 'Neurobehavioural characterisation and stratification of reinforcement-related behaviour', NAT HUM BEHAV, vol. 4, no. 5, pp. 544-558. https://doi.org/10.1038/s41562-020-0846-5

APA

Jia, T., Ing, A., Quinlan, E. B., Tay, N., Luo, Q., Francesca, B., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Bromberg, U., Büchel, C., Desrivières, S., Feng, J., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., ... IMAGEN Consortium (2020). Neurobehavioural characterisation and stratification of reinforcement-related behaviour. NAT HUM BEHAV, 4(5), 544-558. https://doi.org/10.1038/s41562-020-0846-5

Vancouver

Jia T, Ing A, Quinlan EB, Tay N, Luo Q, Francesca B et al. Neurobehavioural characterisation and stratification of reinforcement-related behaviour. NAT HUM BEHAV. 2020 May;4(5):544-558. https://doi.org/10.1038/s41562-020-0846-5

Bibtex

@article{cfc63475f7d2439a9505ed88ea8bd2e4,
title = "Neurobehavioural characterisation and stratification of reinforcement-related behaviour",
abstract = "Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social-emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes and whether neural activation profiles across different reinforcement-related processes might differentiate individual behaviours. We created a statistical framework that enabled us to directly compare functional brain activation during reward anticipation, motor inhibition and viewing emotional faces in the European IMAGEN cohort of 2,000 14-year-old adolescents. We observe significant correlations and modulation of reward anticipation and motor inhibition networks in hyperactivity, impulsivity, inattentive behaviour and conduct symptoms, and we describe neural signatures across cognitive tasks that differentiate these behaviours. We thus characterise shared and distinct functional brain activation patterns underling different externalising symptoms and identify neural stratification markers, while accounting for clinically observed comorbidity.",
keywords = "Adolescent, Anticipation, Psychological/physiology, Attention/physiology, Brain/diagnostic imaging, Child, Cognition/physiology, Facial Expression, Female, Functional Neuroimaging, Humans, Impulsive Behavior/physiology, Magnetic Resonance Imaging, Male, Nerve Net/diagnostic imaging, Reinforcement, Psychology, Reward",
author = "Tianye Jia and Alex Ing and Quinlan, {Erin Burke} and Nicole Tay and Qiang Luo and Biondo Francesca and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Sylvane Desrivi{\`e}res and Jianfeng Feng and Herta Flor and Antoine Grigis and Hugh Garavan and Penny Gowland and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and Martinot, {Marie-Laure Paill{\`e}re} and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Tom{\'a}{\v s} Paus and Luise Poustka and Fr{\"o}hner, {Juliane H} and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Gunter Schumann and {IMAGEN Consortium}",
year = "2020",
month = may,
doi = "10.1038/s41562-020-0846-5",
language = "English",
volume = "4",
pages = "544--558",
journal = "NAT HUM BEHAV",
issn = "2397-3374",
publisher = "NATURE PUBLISHING GROUP",
number = "5",

}

RIS

TY - JOUR

T1 - Neurobehavioural characterisation and stratification of reinforcement-related behaviour

AU - Jia, Tianye

AU - Ing, Alex

AU - Quinlan, Erin Burke

AU - Tay, Nicole

AU - Luo, Qiang

AU - Francesca, Biondo

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Desrivières, Sylvane

AU - Feng, Jianfeng

AU - Flor, Herta

AU - Grigis, Antoine

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Martinot, Marie-Laure Paillère

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Fröhner, Juliane H

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - IMAGEN Consortium

PY - 2020/5

Y1 - 2020/5

N2 - Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social-emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes and whether neural activation profiles across different reinforcement-related processes might differentiate individual behaviours. We created a statistical framework that enabled us to directly compare functional brain activation during reward anticipation, motor inhibition and viewing emotional faces in the European IMAGEN cohort of 2,000 14-year-old adolescents. We observe significant correlations and modulation of reward anticipation and motor inhibition networks in hyperactivity, impulsivity, inattentive behaviour and conduct symptoms, and we describe neural signatures across cognitive tasks that differentiate these behaviours. We thus characterise shared and distinct functional brain activation patterns underling different externalising symptoms and identify neural stratification markers, while accounting for clinically observed comorbidity.

AB - Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social-emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes and whether neural activation profiles across different reinforcement-related processes might differentiate individual behaviours. We created a statistical framework that enabled us to directly compare functional brain activation during reward anticipation, motor inhibition and viewing emotional faces in the European IMAGEN cohort of 2,000 14-year-old adolescents. We observe significant correlations and modulation of reward anticipation and motor inhibition networks in hyperactivity, impulsivity, inattentive behaviour and conduct symptoms, and we describe neural signatures across cognitive tasks that differentiate these behaviours. We thus characterise shared and distinct functional brain activation patterns underling different externalising symptoms and identify neural stratification markers, while accounting for clinically observed comorbidity.

KW - Adolescent

KW - Anticipation, Psychological/physiology

KW - Attention/physiology

KW - Brain/diagnostic imaging

KW - Child

KW - Cognition/physiology

KW - Facial Expression

KW - Female

KW - Functional Neuroimaging

KW - Humans

KW - Impulsive Behavior/physiology

KW - Magnetic Resonance Imaging

KW - Male

KW - Nerve Net/diagnostic imaging

KW - Reinforcement, Psychology

KW - Reward

U2 - 10.1038/s41562-020-0846-5

DO - 10.1038/s41562-020-0846-5

M3 - SCORING: Journal article

C2 - 32313235

VL - 4

SP - 544

EP - 558

JO - NAT HUM BEHAV

JF - NAT HUM BEHAV

SN - 2397-3374

IS - 5

ER -