Neurobehavioural characterisation and stratification of reinforcement-related behaviour
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Neurobehavioural characterisation and stratification of reinforcement-related behaviour. / Jia, Tianye; Ing, Alex; Quinlan, Erin Burke; Tay, Nicole; Luo, Qiang; Francesca, Biondo; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Desrivières, Sylvane; Feng, Jianfeng; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Schumann, Gunter; IMAGEN Consortium.
in: NAT HUM BEHAV, Jahrgang 4, Nr. 5, 05.2020, S. 544-558.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Neurobehavioural characterisation and stratification of reinforcement-related behaviour
AU - Jia, Tianye
AU - Ing, Alex
AU - Quinlan, Erin Burke
AU - Tay, Nicole
AU - Luo, Qiang
AU - Francesca, Biondo
AU - Banaschewski, Tobias
AU - Barker, Gareth J
AU - Bokde, Arun L W
AU - Bromberg, Uli
AU - Büchel, Christian
AU - Desrivières, Sylvane
AU - Feng, Jianfeng
AU - Flor, Herta
AU - Grigis, Antoine
AU - Garavan, Hugh
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Ittermann, Bernd
AU - Martinot, Jean-Luc
AU - Martinot, Marie-Laure Paillère
AU - Nees, Frauke
AU - Orfanos, Dimitri Papadopoulos
AU - Paus, Tomáš
AU - Poustka, Luise
AU - Fröhner, Juliane H
AU - Smolka, Michael N
AU - Walter, Henrik
AU - Whelan, Robert
AU - Schumann, Gunter
AU - IMAGEN Consortium
PY - 2020/5
Y1 - 2020/5
N2 - Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social-emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes and whether neural activation profiles across different reinforcement-related processes might differentiate individual behaviours. We created a statistical framework that enabled us to directly compare functional brain activation during reward anticipation, motor inhibition and viewing emotional faces in the European IMAGEN cohort of 2,000 14-year-old adolescents. We observe significant correlations and modulation of reward anticipation and motor inhibition networks in hyperactivity, impulsivity, inattentive behaviour and conduct symptoms, and we describe neural signatures across cognitive tasks that differentiate these behaviours. We thus characterise shared and distinct functional brain activation patterns underling different externalising symptoms and identify neural stratification markers, while accounting for clinically observed comorbidity.
AB - Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social-emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes and whether neural activation profiles across different reinforcement-related processes might differentiate individual behaviours. We created a statistical framework that enabled us to directly compare functional brain activation during reward anticipation, motor inhibition and viewing emotional faces in the European IMAGEN cohort of 2,000 14-year-old adolescents. We observe significant correlations and modulation of reward anticipation and motor inhibition networks in hyperactivity, impulsivity, inattentive behaviour and conduct symptoms, and we describe neural signatures across cognitive tasks that differentiate these behaviours. We thus characterise shared and distinct functional brain activation patterns underling different externalising symptoms and identify neural stratification markers, while accounting for clinically observed comorbidity.
KW - Adolescent
KW - Anticipation, Psychological/physiology
KW - Attention/physiology
KW - Brain/diagnostic imaging
KW - Child
KW - Cognition/physiology
KW - Facial Expression
KW - Female
KW - Functional Neuroimaging
KW - Humans
KW - Impulsive Behavior/physiology
KW - Magnetic Resonance Imaging
KW - Male
KW - Nerve Net/diagnostic imaging
KW - Reinforcement, Psychology
KW - Reward
U2 - 10.1038/s41562-020-0846-5
DO - 10.1038/s41562-020-0846-5
M3 - SCORING: Journal article
C2 - 32313235
VL - 4
SP - 544
EP - 558
JO - NAT HUM BEHAV
JF - NAT HUM BEHAV
SN - 2397-3374
IS - 5
ER -