Neural mechanisms of perceptual decision-making and their link to neuropsychiatric symptoms in multiple sclerosis
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Neural mechanisms of perceptual decision-making and their link to neuropsychiatric symptoms in multiple sclerosis. / Weygandt, Martin; Behrens, Janina; Brasanac, Jelena; Söder, Eveline; Meyer-Arndt, Lil; Wakonig, Katharina; Ritter, Kerstin; Brandt, Alexander U; Bellmann-Strobl, Judith; Gold, Stefan M; Haynes, John-Dylan; Paul, Friedemann.
In: MULT SCLER RELAT DIS, Vol. 33, 08.2019, p. 139-145.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Neural mechanisms of perceptual decision-making and their link to neuropsychiatric symptoms in multiple sclerosis
AU - Weygandt, Martin
AU - Behrens, Janina
AU - Brasanac, Jelena
AU - Söder, Eveline
AU - Meyer-Arndt, Lil
AU - Wakonig, Katharina
AU - Ritter, Kerstin
AU - Brandt, Alexander U
AU - Bellmann-Strobl, Judith
AU - Gold, Stefan M
AU - Haynes, John-Dylan
AU - Paul, Friedemann
N1 - Copyright © 2019 Elsevier B.V. All rights reserved.
PY - 2019/8
Y1 - 2019/8
N2 - BACKGROUND: Decision-making (DM) capabilities are impaired in multiple sclerosis (MS). A variety of researchers hypothesized that this impairment is associated with reduced quality of life (QoL) and neuropsychiatric symptoms. Studies explicitly testing this hypothesis, however, are rare, provided inconclusive results, or evaluated only a limited selection of DM domains. Consequently, we conducted the first MS study on perceptual DM (e.g. deciding whether a car will fit into a parking lot based on a visual percept) to test this assumption.METHODS: Specifically, we used an fMRI task that measured brain activity in 30 MS patients and 19 healthy controls (HCs) while the participants repeatedly decided whether objects referenced indirectly via their written object names would fit into a shoebox to investigate neural mechanisms of perceptual DM. The objects varied in size and thus decision difficulty. From these data, we determined voxel-wise brain activity parameters reflecting (i) decision difficulty and (ii) decision speed and related them to behavioral DM performance, QoL, mild to moderate depressive symptoms, and fatigue.RESULTS: Patients showed reduced DM performance. Activity reflecting decision difficulty in the middle temporal gyrus was negatively related to DM performance across MS patients and HCs; activity reflecting decision speed in MS patients was associated with depressive symptoms and fatigue in areas of the dorsal visual stream.CONCLUSION: The study shows that the perceptual DM capacity is reduced in MS. Moreover, the link between neural mechanisms of perceptual DM and neuropsychiatric symptoms suggests that an impairment in this domain is clinically relevant.
AB - BACKGROUND: Decision-making (DM) capabilities are impaired in multiple sclerosis (MS). A variety of researchers hypothesized that this impairment is associated with reduced quality of life (QoL) and neuropsychiatric symptoms. Studies explicitly testing this hypothesis, however, are rare, provided inconclusive results, or evaluated only a limited selection of DM domains. Consequently, we conducted the first MS study on perceptual DM (e.g. deciding whether a car will fit into a parking lot based on a visual percept) to test this assumption.METHODS: Specifically, we used an fMRI task that measured brain activity in 30 MS patients and 19 healthy controls (HCs) while the participants repeatedly decided whether objects referenced indirectly via their written object names would fit into a shoebox to investigate neural mechanisms of perceptual DM. The objects varied in size and thus decision difficulty. From these data, we determined voxel-wise brain activity parameters reflecting (i) decision difficulty and (ii) decision speed and related them to behavioral DM performance, QoL, mild to moderate depressive symptoms, and fatigue.RESULTS: Patients showed reduced DM performance. Activity reflecting decision difficulty in the middle temporal gyrus was negatively related to DM performance across MS patients and HCs; activity reflecting decision speed in MS patients was associated with depressive symptoms and fatigue in areas of the dorsal visual stream.CONCLUSION: The study shows that the perceptual DM capacity is reduced in MS. Moreover, the link between neural mechanisms of perceptual DM and neuropsychiatric symptoms suggests that an impairment in this domain is clinically relevant.
U2 - 10.1016/j.msard.2019.05.025
DO - 10.1016/j.msard.2019.05.025
M3 - SCORING: Journal article
C2 - 31195338
VL - 33
SP - 139
EP - 145
JO - MULT SCLER RELAT DIS
JF - MULT SCLER RELAT DIS
SN - 2211-0348
ER -