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Neural mechanisms of perceptual decision-making and their link to neuropsychiatric symptoms in multiple sclerosis

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Neural mechanisms of perceptual decision-making and their link to neuropsychiatric symptoms in multiple sclerosis. / Weygandt, Martin; Behrens, Janina; Brasanac, Jelena; Söder, Eveline; Meyer-Arndt, Lil; Wakonig, Katharina; Ritter, Kerstin; Brandt, Alexander U; Bellmann-Strobl, Judith; Gold, Stefan M; Haynes, John-Dylan; Paul, Friedemann.

in: MULT SCLER RELAT DIS, Jahrgang 33, 08.2019, S. 139-145.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Weygandt, M, Behrens, J, Brasanac, J, Söder, E, Meyer-Arndt, L, Wakonig, K, Ritter, K, Brandt, AU, Bellmann-Strobl, J, Gold, SM, Haynes, J-D & Paul, F 2019, 'Neural mechanisms of perceptual decision-making and their link to neuropsychiatric symptoms in multiple sclerosis', MULT SCLER RELAT DIS, Jg. 33, S. 139-145. https://doi.org/10.1016/j.msard.2019.05.025

APA

Weygandt, M., Behrens, J., Brasanac, J., Söder, E., Meyer-Arndt, L., Wakonig, K., Ritter, K., Brandt, A. U., Bellmann-Strobl, J., Gold, S. M., Haynes, J-D., & Paul, F. (2019). Neural mechanisms of perceptual decision-making and their link to neuropsychiatric symptoms in multiple sclerosis. MULT SCLER RELAT DIS, 33, 139-145. https://doi.org/10.1016/j.msard.2019.05.025

Vancouver

Weygandt M, Behrens J, Brasanac J, Söder E, Meyer-Arndt L, Wakonig K et al. Neural mechanisms of perceptual decision-making and their link to neuropsychiatric symptoms in multiple sclerosis. MULT SCLER RELAT DIS. 2019 Aug;33:139-145. https://doi.org/10.1016/j.msard.2019.05.025

Bibtex

@article{5e50091b5c074552a87389a866d4eb54,
title = "Neural mechanisms of perceptual decision-making and their link to neuropsychiatric symptoms in multiple sclerosis",
abstract = "BACKGROUND: Decision-making (DM) capabilities are impaired in multiple sclerosis (MS). A variety of researchers hypothesized that this impairment is associated with reduced quality of life (QoL) and neuropsychiatric symptoms. Studies explicitly testing this hypothesis, however, are rare, provided inconclusive results, or evaluated only a limited selection of DM domains. Consequently, we conducted the first MS study on perceptual DM (e.g. deciding whether a car will fit into a parking lot based on a visual percept) to test this assumption.METHODS: Specifically, we used an fMRI task that measured brain activity in 30 MS patients and 19 healthy controls (HCs) while the participants repeatedly decided whether objects referenced indirectly via their written object names would fit into a shoebox to investigate neural mechanisms of perceptual DM. The objects varied in size and thus decision difficulty. From these data, we determined voxel-wise brain activity parameters reflecting (i) decision difficulty and (ii) decision speed and related them to behavioral DM performance, QoL, mild to moderate depressive symptoms, and fatigue.RESULTS: Patients showed reduced DM performance. Activity reflecting decision difficulty in the middle temporal gyrus was negatively related to DM performance across MS patients and HCs; activity reflecting decision speed in MS patients was associated with depressive symptoms and fatigue in areas of the dorsal visual stream.CONCLUSION: The study shows that the perceptual DM capacity is reduced in MS. Moreover, the link between neural mechanisms of perceptual DM and neuropsychiatric symptoms suggests that an impairment in this domain is clinically relevant.",
author = "Martin Weygandt and Janina Behrens and Jelena Brasanac and Eveline S{\"o}der and Lil Meyer-Arndt and Katharina Wakonig and Kerstin Ritter and Brandt, {Alexander U} and Judith Bellmann-Strobl and Gold, {Stefan M} and John-Dylan Haynes and Friedemann Paul",
note = "Copyright {\textcopyright} 2019 Elsevier B.V. All rights reserved.",
year = "2019",
month = aug,
doi = "10.1016/j.msard.2019.05.025",
language = "English",
volume = "33",
pages = "139--145",
journal = "MULT SCLER RELAT DIS",
issn = "2211-0348",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Neural mechanisms of perceptual decision-making and their link to neuropsychiatric symptoms in multiple sclerosis

AU - Weygandt, Martin

AU - Behrens, Janina

AU - Brasanac, Jelena

AU - Söder, Eveline

AU - Meyer-Arndt, Lil

AU - Wakonig, Katharina

AU - Ritter, Kerstin

AU - Brandt, Alexander U

AU - Bellmann-Strobl, Judith

AU - Gold, Stefan M

AU - Haynes, John-Dylan

AU - Paul, Friedemann

N1 - Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2019/8

Y1 - 2019/8

N2 - BACKGROUND: Decision-making (DM) capabilities are impaired in multiple sclerosis (MS). A variety of researchers hypothesized that this impairment is associated with reduced quality of life (QoL) and neuropsychiatric symptoms. Studies explicitly testing this hypothesis, however, are rare, provided inconclusive results, or evaluated only a limited selection of DM domains. Consequently, we conducted the first MS study on perceptual DM (e.g. deciding whether a car will fit into a parking lot based on a visual percept) to test this assumption.METHODS: Specifically, we used an fMRI task that measured brain activity in 30 MS patients and 19 healthy controls (HCs) while the participants repeatedly decided whether objects referenced indirectly via their written object names would fit into a shoebox to investigate neural mechanisms of perceptual DM. The objects varied in size and thus decision difficulty. From these data, we determined voxel-wise brain activity parameters reflecting (i) decision difficulty and (ii) decision speed and related them to behavioral DM performance, QoL, mild to moderate depressive symptoms, and fatigue.RESULTS: Patients showed reduced DM performance. Activity reflecting decision difficulty in the middle temporal gyrus was negatively related to DM performance across MS patients and HCs; activity reflecting decision speed in MS patients was associated with depressive symptoms and fatigue in areas of the dorsal visual stream.CONCLUSION: The study shows that the perceptual DM capacity is reduced in MS. Moreover, the link between neural mechanisms of perceptual DM and neuropsychiatric symptoms suggests that an impairment in this domain is clinically relevant.

AB - BACKGROUND: Decision-making (DM) capabilities are impaired in multiple sclerosis (MS). A variety of researchers hypothesized that this impairment is associated with reduced quality of life (QoL) and neuropsychiatric symptoms. Studies explicitly testing this hypothesis, however, are rare, provided inconclusive results, or evaluated only a limited selection of DM domains. Consequently, we conducted the first MS study on perceptual DM (e.g. deciding whether a car will fit into a parking lot based on a visual percept) to test this assumption.METHODS: Specifically, we used an fMRI task that measured brain activity in 30 MS patients and 19 healthy controls (HCs) while the participants repeatedly decided whether objects referenced indirectly via their written object names would fit into a shoebox to investigate neural mechanisms of perceptual DM. The objects varied in size and thus decision difficulty. From these data, we determined voxel-wise brain activity parameters reflecting (i) decision difficulty and (ii) decision speed and related them to behavioral DM performance, QoL, mild to moderate depressive symptoms, and fatigue.RESULTS: Patients showed reduced DM performance. Activity reflecting decision difficulty in the middle temporal gyrus was negatively related to DM performance across MS patients and HCs; activity reflecting decision speed in MS patients was associated with depressive symptoms and fatigue in areas of the dorsal visual stream.CONCLUSION: The study shows that the perceptual DM capacity is reduced in MS. Moreover, the link between neural mechanisms of perceptual DM and neuropsychiatric symptoms suggests that an impairment in this domain is clinically relevant.

U2 - 10.1016/j.msard.2019.05.025

DO - 10.1016/j.msard.2019.05.025

M3 - SCORING: Journal article

C2 - 31195338

VL - 33

SP - 139

EP - 145

JO - MULT SCLER RELAT DIS

JF - MULT SCLER RELAT DIS

SN - 2211-0348

ER -