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Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders

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Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders. / Chaarani, Bader; Kan, Kees-Jan; Mackey, Scott; Spechler, Philip A; Potter, Alexandra; Banaschewski, Tobias; Millenet, Sabina; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Cattrell, Anna; Conrod, Patricia J; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Nees, Frauke; Paus, Tomáš; Poustka, Luise; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Stringaris, Argyris; Higgins, Stephen T; Schumann, Gunter; Garavan, Hugh; Althoff, Robert R; IMAGEN Consortium.

In: J AM ACAD CHILD PSY, Vol. 59, No. 12, 12.2020, p. 1371-1379.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Chaarani, B, Kan, K-J, Mackey, S, Spechler, PA, Potter, A, Banaschewski, T, Millenet, S, Bokde, ALW, Bromberg, U, Büchel, C, Cattrell, A, Conrod, PJ, Desrivières, S, Flor, H, Frouin, V, Gallinat, J, Gowland, P, Heinz, A, Ittermann, B, Martinot, J-L, Nees, F, Paus, T, Poustka, L, Smolka, MN, Walter, H, Whelan, R, Stringaris, A, Higgins, ST, Schumann, G, Garavan, H, Althoff, RR & IMAGEN Consortium 2020, 'Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders', J AM ACAD CHILD PSY, vol. 59, no. 12, pp. 1371-1379. https://doi.org/10.1016/j.jaac.2019.11.028

APA

Chaarani, B., Kan, K-J., Mackey, S., Spechler, P. A., Potter, A., Banaschewski, T., Millenet, S., Bokde, A. L. W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P. J., Desrivières, S., Flor, H., Frouin, V., Gallinat, J., Gowland, P., Heinz, A., Ittermann, B., ... IMAGEN Consortium (2020). Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders. J AM ACAD CHILD PSY, 59(12), 1371-1379. https://doi.org/10.1016/j.jaac.2019.11.028

Vancouver

Chaarani B, Kan K-J, Mackey S, Spechler PA, Potter A, Banaschewski T et al. Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders. J AM ACAD CHILD PSY. 2020 Dec;59(12):1371-1379. https://doi.org/10.1016/j.jaac.2019.11.028

Bibtex

@article{6a4b28005f74429a8e0487c6a0ee9436,
title = "Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders",
abstract = "OBJECTIVE: Irritable mood, a common and impairing symptom in psychopathology, has been proposed to underlie the developmental link between oppositional problems in youth and depression in adulthood. We examined the neural correlates of adolescent irritability in IMAGEN, a sample of 2,024 14-year-old adolescents from 5 European countries.METHOD: The Development and Well-Being Assessment (DAWBA) was used to assess attention-deficit/hyperactivity disorder, major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder. Three items from the DAWBA, selected as close matches to the Affective Reactivity Index, were used to assess irritability. Structural magnetic resonance imaging was examined using whole-brain voxel-based morphometry analysis, and functional magnetic resonance imaging was examined during a stop signal task of inhibitory control. Imaging data were included in structural equation models to examine the direct and indirect associations between irritable mood and comorbid DSM diagnoses.RESULTS: Whole-brain voxelwise analysis showed that adolescent irritable mood was associated with less gray matter volume and less neural activation underlying inhibitory control in frontal and temporal cortical areas (cluster-correction at p < .05). Structural equation models suggested that part of the observed smaller gray matter volume was exclusively driven by irritability separate from direct relationships between generalized anxiety disorder (or attention-deficit/hyperactivity disorder, major depressive disorder, or oppositional defiant disorder) and gray matter volume.CONCLUSION: This study identifies adolescent irritability as an independent construct and points to a neurobiological correlate to irritability that is an important contributing feature to many psychopathological disorders.",
author = "Bader Chaarani and Kees-Jan Kan and Scott Mackey and Spechler, {Philip A} and Alexandra Potter and Tobias Banaschewski and Sabina Millenet and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Anna Cattrell and Conrod, {Patricia J} and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and J{\"u}rgen Gallinat and Penny Gowland and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and Frauke Nees and Tom{\'a}{\v s} Paus and Luise Poustka and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Argyris Stringaris and Higgins, {Stephen T} and Gunter Schumann and Hugh Garavan and Althoff, {Robert R} and {IMAGEN Consortium}",
note = "Copyright {\textcopyright} 2020. Published by Elsevier Inc.",
year = "2020",
month = dec,
doi = "10.1016/j.jaac.2019.11.028",
language = "English",
volume = "59",
pages = "1371--1379",
journal = "J AM ACAD CHILD PSY",
issn = "0890-8567",
publisher = "Elsevier Limited",
number = "12",

}

RIS

TY - JOUR

T1 - Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders

AU - Chaarani, Bader

AU - Kan, Kees-Jan

AU - Mackey, Scott

AU - Spechler, Philip A

AU - Potter, Alexandra

AU - Banaschewski, Tobias

AU - Millenet, Sabina

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Cattrell, Anna

AU - Conrod, Patricia J

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gallinat, Jürgen

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Nees, Frauke

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Stringaris, Argyris

AU - Higgins, Stephen T

AU - Schumann, Gunter

AU - Garavan, Hugh

AU - Althoff, Robert R

AU - IMAGEN Consortium

N1 - Copyright © 2020. Published by Elsevier Inc.

PY - 2020/12

Y1 - 2020/12

N2 - OBJECTIVE: Irritable mood, a common and impairing symptom in psychopathology, has been proposed to underlie the developmental link between oppositional problems in youth and depression in adulthood. We examined the neural correlates of adolescent irritability in IMAGEN, a sample of 2,024 14-year-old adolescents from 5 European countries.METHOD: The Development and Well-Being Assessment (DAWBA) was used to assess attention-deficit/hyperactivity disorder, major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder. Three items from the DAWBA, selected as close matches to the Affective Reactivity Index, were used to assess irritability. Structural magnetic resonance imaging was examined using whole-brain voxel-based morphometry analysis, and functional magnetic resonance imaging was examined during a stop signal task of inhibitory control. Imaging data were included in structural equation models to examine the direct and indirect associations between irritable mood and comorbid DSM diagnoses.RESULTS: Whole-brain voxelwise analysis showed that adolescent irritable mood was associated with less gray matter volume and less neural activation underlying inhibitory control in frontal and temporal cortical areas (cluster-correction at p < .05). Structural equation models suggested that part of the observed smaller gray matter volume was exclusively driven by irritability separate from direct relationships between generalized anxiety disorder (or attention-deficit/hyperactivity disorder, major depressive disorder, or oppositional defiant disorder) and gray matter volume.CONCLUSION: This study identifies adolescent irritability as an independent construct and points to a neurobiological correlate to irritability that is an important contributing feature to many psychopathological disorders.

AB - OBJECTIVE: Irritable mood, a common and impairing symptom in psychopathology, has been proposed to underlie the developmental link between oppositional problems in youth and depression in adulthood. We examined the neural correlates of adolescent irritability in IMAGEN, a sample of 2,024 14-year-old adolescents from 5 European countries.METHOD: The Development and Well-Being Assessment (DAWBA) was used to assess attention-deficit/hyperactivity disorder, major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder. Three items from the DAWBA, selected as close matches to the Affective Reactivity Index, were used to assess irritability. Structural magnetic resonance imaging was examined using whole-brain voxel-based morphometry analysis, and functional magnetic resonance imaging was examined during a stop signal task of inhibitory control. Imaging data were included in structural equation models to examine the direct and indirect associations between irritable mood and comorbid DSM diagnoses.RESULTS: Whole-brain voxelwise analysis showed that adolescent irritable mood was associated with less gray matter volume and less neural activation underlying inhibitory control in frontal and temporal cortical areas (cluster-correction at p < .05). Structural equation models suggested that part of the observed smaller gray matter volume was exclusively driven by irritability separate from direct relationships between generalized anxiety disorder (or attention-deficit/hyperactivity disorder, major depressive disorder, or oppositional defiant disorder) and gray matter volume.CONCLUSION: This study identifies adolescent irritability as an independent construct and points to a neurobiological correlate to irritability that is an important contributing feature to many psychopathological disorders.

U2 - 10.1016/j.jaac.2019.11.028

DO - 10.1016/j.jaac.2019.11.028

M3 - SCORING: Journal article

C2 - 32860907

VL - 59

SP - 1371

EP - 1379

JO - J AM ACAD CHILD PSY

JF - J AM ACAD CHILD PSY

SN - 0890-8567

IS - 12

ER -