Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders
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Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders. / Chaarani, Bader; Kan, Kees-Jan; Mackey, Scott; Spechler, Philip A; Potter, Alexandra; Banaschewski, Tobias; Millenet, Sabina; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Cattrell, Anna; Conrod, Patricia J; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Nees, Frauke; Paus, Tomáš; Poustka, Luise; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Stringaris, Argyris; Higgins, Stephen T; Schumann, Gunter; Garavan, Hugh; Althoff, Robert R; IMAGEN Consortium.
in: J AM ACAD CHILD PSY, Jahrgang 59, Nr. 12, 12.2020, S. 1371-1379.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders
AU - Chaarani, Bader
AU - Kan, Kees-Jan
AU - Mackey, Scott
AU - Spechler, Philip A
AU - Potter, Alexandra
AU - Banaschewski, Tobias
AU - Millenet, Sabina
AU - Bokde, Arun L W
AU - Bromberg, Uli
AU - Büchel, Christian
AU - Cattrell, Anna
AU - Conrod, Patricia J
AU - Desrivières, Sylvane
AU - Flor, Herta
AU - Frouin, Vincent
AU - Gallinat, Jürgen
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Ittermann, Bernd
AU - Martinot, Jean-Luc
AU - Nees, Frauke
AU - Paus, Tomáš
AU - Poustka, Luise
AU - Smolka, Michael N
AU - Walter, Henrik
AU - Whelan, Robert
AU - Stringaris, Argyris
AU - Higgins, Stephen T
AU - Schumann, Gunter
AU - Garavan, Hugh
AU - Althoff, Robert R
AU - IMAGEN Consortium
N1 - Copyright © 2020. Published by Elsevier Inc.
PY - 2020/12
Y1 - 2020/12
N2 - OBJECTIVE: Irritable mood, a common and impairing symptom in psychopathology, has been proposed to underlie the developmental link between oppositional problems in youth and depression in adulthood. We examined the neural correlates of adolescent irritability in IMAGEN, a sample of 2,024 14-year-old adolescents from 5 European countries.METHOD: The Development and Well-Being Assessment (DAWBA) was used to assess attention-deficit/hyperactivity disorder, major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder. Three items from the DAWBA, selected as close matches to the Affective Reactivity Index, were used to assess irritability. Structural magnetic resonance imaging was examined using whole-brain voxel-based morphometry analysis, and functional magnetic resonance imaging was examined during a stop signal task of inhibitory control. Imaging data were included in structural equation models to examine the direct and indirect associations between irritable mood and comorbid DSM diagnoses.RESULTS: Whole-brain voxelwise analysis showed that adolescent irritable mood was associated with less gray matter volume and less neural activation underlying inhibitory control in frontal and temporal cortical areas (cluster-correction at p < .05). Structural equation models suggested that part of the observed smaller gray matter volume was exclusively driven by irritability separate from direct relationships between generalized anxiety disorder (or attention-deficit/hyperactivity disorder, major depressive disorder, or oppositional defiant disorder) and gray matter volume.CONCLUSION: This study identifies adolescent irritability as an independent construct and points to a neurobiological correlate to irritability that is an important contributing feature to many psychopathological disorders.
AB - OBJECTIVE: Irritable mood, a common and impairing symptom in psychopathology, has been proposed to underlie the developmental link between oppositional problems in youth and depression in adulthood. We examined the neural correlates of adolescent irritability in IMAGEN, a sample of 2,024 14-year-old adolescents from 5 European countries.METHOD: The Development and Well-Being Assessment (DAWBA) was used to assess attention-deficit/hyperactivity disorder, major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder. Three items from the DAWBA, selected as close matches to the Affective Reactivity Index, were used to assess irritability. Structural magnetic resonance imaging was examined using whole-brain voxel-based morphometry analysis, and functional magnetic resonance imaging was examined during a stop signal task of inhibitory control. Imaging data were included in structural equation models to examine the direct and indirect associations between irritable mood and comorbid DSM diagnoses.RESULTS: Whole-brain voxelwise analysis showed that adolescent irritable mood was associated with less gray matter volume and less neural activation underlying inhibitory control in frontal and temporal cortical areas (cluster-correction at p < .05). Structural equation models suggested that part of the observed smaller gray matter volume was exclusively driven by irritability separate from direct relationships between generalized anxiety disorder (or attention-deficit/hyperactivity disorder, major depressive disorder, or oppositional defiant disorder) and gray matter volume.CONCLUSION: This study identifies adolescent irritability as an independent construct and points to a neurobiological correlate to irritability that is an important contributing feature to many psychopathological disorders.
U2 - 10.1016/j.jaac.2019.11.028
DO - 10.1016/j.jaac.2019.11.028
M3 - SCORING: Journal article
C2 - 32860907
VL - 59
SP - 1371
EP - 1379
JO - J AM ACAD CHILD PSY
JF - J AM ACAD CHILD PSY
SN - 0890-8567
IS - 12
ER -