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Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy

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Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy. / Deppe, M; Kellinghaus, C; Duning, T; Möddel, G; Mohammadi, S; Deppe, K; Schiffbauer, H; Kugel, H; Keller, S S; Ringelstein, E B; Knecht, S.

In: NEUROLOGY, Vol. 71, No. 24, 09.12.2008, p. 1981-5.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Deppe, M, Kellinghaus, C, Duning, T, Möddel, G, Mohammadi, S, Deppe, K, Schiffbauer, H, Kugel, H, Keller, SS, Ringelstein, EB & Knecht, S 2008, 'Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy', NEUROLOGY, vol. 71, no. 24, pp. 1981-5. https://doi.org/10.1212/01.wnl.0000336969.98241.17

APA

Deppe, M., Kellinghaus, C., Duning, T., Möddel, G., Mohammadi, S., Deppe, K., Schiffbauer, H., Kugel, H., Keller, S. S., Ringelstein, E. B., & Knecht, S. (2008). Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy. NEUROLOGY, 71(24), 1981-5. https://doi.org/10.1212/01.wnl.0000336969.98241.17

Vancouver

Deppe M, Kellinghaus C, Duning T, Möddel G, Mohammadi S, Deppe K et al. Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy. NEUROLOGY. 2008 Dec 9;71(24):1981-5. https://doi.org/10.1212/01.wnl.0000336969.98241.17

Bibtex

@article{e7f63a4e7a2c476089d16320f3d4cfd8,
title = "Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy",
abstract = "BACKGROUND: Juvenile myoclonic epilepsy (JME) is a syndrome of idiopathic generalized epilepsy (IGE) without structural brain abnormalities detectable by MRI or CT.OBJECTIVE: In the present study, we addressed the question of whether diffusion tensor MRI (DTI) can detect disease-specific white matter (WM) abnormalities in patients with JME.METHODS: We performed whole head DTI at 3 T in 10 patients with JME, 8 age-matched patients with cryptogenic partial epilepsy (CPE), and 67 age-matched healthy volunteers. Nerve fiber integrity was compared between the groups on the basis of optimized voxel-by-voxel statistics of fractional anisotropy (FA) maps obtained by DTI (analysis of covariance, categorical factor {"}group,{"} covariate {"}age{"}).RESULTS: FA was reduced in a WM region associated with the anterior thalamus and prefrontal cortex in patients with JME compared to both control subjects and patients with CPE (p < 0.001). The patients with CPE showed normal values in this particular WM region. The FA reductions in the patients with JME correlated with the frequency of generalized tonic-clonic seizures (Spearman R = 0.54, p = 0.05). No significant correlations were found in the JME sample between FA reduction and the duration of antiepileptic medication.CONCLUSIONS: The results support the hypothesis that juvenile myoclonic epilepsy is associated with abnormalities of the thalamocortical network that can be detected by diffusion tensor MRI.",
keywords = "Adult, Anisotropy, Brain Mapping, Cerebral Cortex, Cognition Disorders, Diffusion Magnetic Resonance Imaging, Disease Progression, Female, Humans, Male, Myoclonic Epilepsy, Juvenile, Nerve Fibers, Myelinated, Nerve Net, Neural Pathways, Predictive Value of Tests, Prefrontal Cortex, Seizures, Thalamus, Wallerian Degeneration, Young Adult",
author = "M Deppe and C Kellinghaus and T Duning and G M{\"o}ddel and S Mohammadi and K Deppe and H Schiffbauer and H Kugel and Keller, {S S} and Ringelstein, {E B} and S Knecht",
year = "2008",
month = dec,
day = "9",
doi = "10.1212/01.wnl.0000336969.98241.17",
language = "English",
volume = "71",
pages = "1981--5",
journal = "NEUROLOGY",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "24",

}

RIS

TY - JOUR

T1 - Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy

AU - Deppe, M

AU - Kellinghaus, C

AU - Duning, T

AU - Möddel, G

AU - Mohammadi, S

AU - Deppe, K

AU - Schiffbauer, H

AU - Kugel, H

AU - Keller, S S

AU - Ringelstein, E B

AU - Knecht, S

PY - 2008/12/9

Y1 - 2008/12/9

N2 - BACKGROUND: Juvenile myoclonic epilepsy (JME) is a syndrome of idiopathic generalized epilepsy (IGE) without structural brain abnormalities detectable by MRI or CT.OBJECTIVE: In the present study, we addressed the question of whether diffusion tensor MRI (DTI) can detect disease-specific white matter (WM) abnormalities in patients with JME.METHODS: We performed whole head DTI at 3 T in 10 patients with JME, 8 age-matched patients with cryptogenic partial epilepsy (CPE), and 67 age-matched healthy volunteers. Nerve fiber integrity was compared between the groups on the basis of optimized voxel-by-voxel statistics of fractional anisotropy (FA) maps obtained by DTI (analysis of covariance, categorical factor "group," covariate "age").RESULTS: FA was reduced in a WM region associated with the anterior thalamus and prefrontal cortex in patients with JME compared to both control subjects and patients with CPE (p < 0.001). The patients with CPE showed normal values in this particular WM region. The FA reductions in the patients with JME correlated with the frequency of generalized tonic-clonic seizures (Spearman R = 0.54, p = 0.05). No significant correlations were found in the JME sample between FA reduction and the duration of antiepileptic medication.CONCLUSIONS: The results support the hypothesis that juvenile myoclonic epilepsy is associated with abnormalities of the thalamocortical network that can be detected by diffusion tensor MRI.

AB - BACKGROUND: Juvenile myoclonic epilepsy (JME) is a syndrome of idiopathic generalized epilepsy (IGE) without structural brain abnormalities detectable by MRI or CT.OBJECTIVE: In the present study, we addressed the question of whether diffusion tensor MRI (DTI) can detect disease-specific white matter (WM) abnormalities in patients with JME.METHODS: We performed whole head DTI at 3 T in 10 patients with JME, 8 age-matched patients with cryptogenic partial epilepsy (CPE), and 67 age-matched healthy volunteers. Nerve fiber integrity was compared between the groups on the basis of optimized voxel-by-voxel statistics of fractional anisotropy (FA) maps obtained by DTI (analysis of covariance, categorical factor "group," covariate "age").RESULTS: FA was reduced in a WM region associated with the anterior thalamus and prefrontal cortex in patients with JME compared to both control subjects and patients with CPE (p < 0.001). The patients with CPE showed normal values in this particular WM region. The FA reductions in the patients with JME correlated with the frequency of generalized tonic-clonic seizures (Spearman R = 0.54, p = 0.05). No significant correlations were found in the JME sample between FA reduction and the duration of antiepileptic medication.CONCLUSIONS: The results support the hypothesis that juvenile myoclonic epilepsy is associated with abnormalities of the thalamocortical network that can be detected by diffusion tensor MRI.

KW - Adult

KW - Anisotropy

KW - Brain Mapping

KW - Cerebral Cortex

KW - Cognition Disorders

KW - Diffusion Magnetic Resonance Imaging

KW - Disease Progression

KW - Female

KW - Humans

KW - Male

KW - Myoclonic Epilepsy, Juvenile

KW - Nerve Fibers, Myelinated

KW - Nerve Net

KW - Neural Pathways

KW - Predictive Value of Tests

KW - Prefrontal Cortex

KW - Seizures

KW - Thalamus

KW - Wallerian Degeneration

KW - Young Adult

U2 - 10.1212/01.wnl.0000336969.98241.17

DO - 10.1212/01.wnl.0000336969.98241.17

M3 - SCORING: Journal article

C2 - 19064879

VL - 71

SP - 1981

EP - 1985

JO - NEUROLOGY

JF - NEUROLOGY

SN - 0028-3878

IS - 24

ER -