Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy
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Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy. / Deppe, M; Kellinghaus, C; Duning, T; Möddel, G; Mohammadi, S; Deppe, K; Schiffbauer, H; Kugel, H; Keller, S S; Ringelstein, E B; Knecht, S.
in: NEUROLOGY, Jahrgang 71, Nr. 24, 09.12.2008, S. 1981-5.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy
AU - Deppe, M
AU - Kellinghaus, C
AU - Duning, T
AU - Möddel, G
AU - Mohammadi, S
AU - Deppe, K
AU - Schiffbauer, H
AU - Kugel, H
AU - Keller, S S
AU - Ringelstein, E B
AU - Knecht, S
PY - 2008/12/9
Y1 - 2008/12/9
N2 - BACKGROUND: Juvenile myoclonic epilepsy (JME) is a syndrome of idiopathic generalized epilepsy (IGE) without structural brain abnormalities detectable by MRI or CT.OBJECTIVE: In the present study, we addressed the question of whether diffusion tensor MRI (DTI) can detect disease-specific white matter (WM) abnormalities in patients with JME.METHODS: We performed whole head DTI at 3 T in 10 patients with JME, 8 age-matched patients with cryptogenic partial epilepsy (CPE), and 67 age-matched healthy volunteers. Nerve fiber integrity was compared between the groups on the basis of optimized voxel-by-voxel statistics of fractional anisotropy (FA) maps obtained by DTI (analysis of covariance, categorical factor "group," covariate "age").RESULTS: FA was reduced in a WM region associated with the anterior thalamus and prefrontal cortex in patients with JME compared to both control subjects and patients with CPE (p < 0.001). The patients with CPE showed normal values in this particular WM region. The FA reductions in the patients with JME correlated with the frequency of generalized tonic-clonic seizures (Spearman R = 0.54, p = 0.05). No significant correlations were found in the JME sample between FA reduction and the duration of antiepileptic medication.CONCLUSIONS: The results support the hypothesis that juvenile myoclonic epilepsy is associated with abnormalities of the thalamocortical network that can be detected by diffusion tensor MRI.
AB - BACKGROUND: Juvenile myoclonic epilepsy (JME) is a syndrome of idiopathic generalized epilepsy (IGE) without structural brain abnormalities detectable by MRI or CT.OBJECTIVE: In the present study, we addressed the question of whether diffusion tensor MRI (DTI) can detect disease-specific white matter (WM) abnormalities in patients with JME.METHODS: We performed whole head DTI at 3 T in 10 patients with JME, 8 age-matched patients with cryptogenic partial epilepsy (CPE), and 67 age-matched healthy volunteers. Nerve fiber integrity was compared between the groups on the basis of optimized voxel-by-voxel statistics of fractional anisotropy (FA) maps obtained by DTI (analysis of covariance, categorical factor "group," covariate "age").RESULTS: FA was reduced in a WM region associated with the anterior thalamus and prefrontal cortex in patients with JME compared to both control subjects and patients with CPE (p < 0.001). The patients with CPE showed normal values in this particular WM region. The FA reductions in the patients with JME correlated with the frequency of generalized tonic-clonic seizures (Spearman R = 0.54, p = 0.05). No significant correlations were found in the JME sample between FA reduction and the duration of antiepileptic medication.CONCLUSIONS: The results support the hypothesis that juvenile myoclonic epilepsy is associated with abnormalities of the thalamocortical network that can be detected by diffusion tensor MRI.
KW - Adult
KW - Anisotropy
KW - Brain Mapping
KW - Cerebral Cortex
KW - Cognition Disorders
KW - Diffusion Magnetic Resonance Imaging
KW - Disease Progression
KW - Female
KW - Humans
KW - Male
KW - Myoclonic Epilepsy, Juvenile
KW - Nerve Fibers, Myelinated
KW - Nerve Net
KW - Neural Pathways
KW - Predictive Value of Tests
KW - Prefrontal Cortex
KW - Seizures
KW - Thalamus
KW - Wallerian Degeneration
KW - Young Adult
U2 - 10.1212/01.wnl.0000336969.98241.17
DO - 10.1212/01.wnl.0000336969.98241.17
M3 - SCORING: Journal article
C2 - 19064879
VL - 71
SP - 1981
EP - 1985
JO - NEUROLOGY
JF - NEUROLOGY
SN - 0028-3878
IS - 24
ER -