Nephrogenic systemic fibrosis
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Nephrogenic systemic fibrosis : a systemic fibrosing disease resulting from gadolinium exposure. / Bernstein, Elana J; Schmidt-Lauber, Christian; Kay, Jonathan.
In: BEST PRACT RES CL RH, Vol. 26, No. 4, 08.2012, p. 489-503.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Nephrogenic systemic fibrosis
T2 - a systemic fibrosing disease resulting from gadolinium exposure
AU - Bernstein, Elana J
AU - Schmidt-Lauber, Christian
AU - Kay, Jonathan
N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.
PY - 2012/8
Y1 - 2012/8
N2 - Nephrogenic systemic fibrosis (NSF) is an iatrogenic fibrosing disorder that primarily affects individuals with chronic kidney disease (CKD) following exposure to gadolinium-based contrast agents (GBCAs) during imaging procedures. NSF is characterised by skin thickening, tethering and hyperpigmentation; flexion contractures of joints; and extracutaneous fibrosis. This article reviews the history, clinical manifestations, epidemiology, histopathology and pathophysiology of this disabling disease.
AB - Nephrogenic systemic fibrosis (NSF) is an iatrogenic fibrosing disorder that primarily affects individuals with chronic kidney disease (CKD) following exposure to gadolinium-based contrast agents (GBCAs) during imaging procedures. NSF is characterised by skin thickening, tethering and hyperpigmentation; flexion contractures of joints; and extracutaneous fibrosis. This article reviews the history, clinical manifestations, epidemiology, histopathology and pathophysiology of this disabling disease.
KW - Contracture/chemically induced
KW - Contrast Media/adverse effects
KW - Diagnosis, Differential
KW - Gadolinium/adverse effects
KW - Humans
KW - Hyperpigmentation/chemically induced
KW - Nephrogenic Fibrosing Dermopathy/chemically induced
KW - Renal Insufficiency, Chronic/complications
KW - Risk Factors
KW - Skin/pathology
U2 - 10.1016/j.berh.2012.07.008
DO - 10.1016/j.berh.2012.07.008
M3 - SCORING: Review article
C2 - 23040363
VL - 26
SP - 489
EP - 503
JO - BEST PRACT RES CL RH
JF - BEST PRACT RES CL RH
SN - 1521-6942
IS - 4
ER -