Negative fluid-attenuated inversion recovery imaging identifies acute ischemic stroke at 3 hours or less.
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Negative fluid-attenuated inversion recovery imaging identifies acute ischemic stroke at 3 hours or less. / Thomalla, Götz; Rossbach, Philipp; Rosenkranz, Michael; Siemonsen, Susanne; Krützelmann, Anna; Fiehler, Jens; Gerloff, Christian.
In: ANN NEUROL, Vol. 65, No. 6, 6, 2009, p. 724-732.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Negative fluid-attenuated inversion recovery imaging identifies acute ischemic stroke at 3 hours or less.
AU - Thomalla, Götz
AU - Rossbach, Philipp
AU - Rosenkranz, Michael
AU - Siemonsen, Susanne
AU - Krützelmann, Anna
AU - Fiehler, Jens
AU - Gerloff, Christian
PY - 2009
Y1 - 2009
N2 - OBJECTIVE: o evaluate the use of fluid-attenuated inversion recovery (FLAIR) imaging as surrogate marker of lesion age within the first 6 hours of ischemic stroke. METHODS: e analyzed FLAIR and diffusion-weighted imaging (DWI) sequences performed within 6 hours of symptom onset in 120 consecutive patients with ischemic stroke with known symptom onset. The visibility of acute ischemic lesions on FLAIR images was judged in two steps (on FLAIR alone and with knowledge of DWI) and compared with DWI. RESULTS: egative FLAIR in the case of positive DWI allocated ischemic lesions to a time window 3 hours or less with a high specificity (0.93) and a high positive predictive value (0.94), whereas sensitivity (0.48) and negative predictive value (0.43) were low. Lesion visibility on FLAIR images alone (35.6%) and with knowledge of DWI (62.5%) was lower than on DWI (97.1%). The sensitivity of FLAIR increased with increasing time from symptom onset from 27.0/50.0%
AB - OBJECTIVE: o evaluate the use of fluid-attenuated inversion recovery (FLAIR) imaging as surrogate marker of lesion age within the first 6 hours of ischemic stroke. METHODS: e analyzed FLAIR and diffusion-weighted imaging (DWI) sequences performed within 6 hours of symptom onset in 120 consecutive patients with ischemic stroke with known symptom onset. The visibility of acute ischemic lesions on FLAIR images was judged in two steps (on FLAIR alone and with knowledge of DWI) and compared with DWI. RESULTS: egative FLAIR in the case of positive DWI allocated ischemic lesions to a time window 3 hours or less with a high specificity (0.93) and a high positive predictive value (0.94), whereas sensitivity (0.48) and negative predictive value (0.43) were low. Lesion visibility on FLAIR images alone (35.6%) and with knowledge of DWI (62.5%) was lower than on DWI (97.1%). The sensitivity of FLAIR increased with increasing time from symptom onset from 27.0/50.0%
M3 - SCORING: Zeitschriftenaufsatz
VL - 65
SP - 724
EP - 732
JO - ANN NEUROL
JF - ANN NEUROL
SN - 0364-5134
IS - 6
M1 - 6
ER -