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Natürlicher Verlauf der HPV-Infektion. Nutzen der HPV-Analytik in der Zervixdiagnostik

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Natürlicher Verlauf der HPV-Infektion. Nutzen der HPV-Analytik in der Zervixdiagnostik. / Milde-Langosch, K; Riethdorf, S; Park, T W.

In: PATHOLOGE, Vol. 20, No. 1, 01.1999, p. 15-24.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Milde-Langosch, K, Riethdorf, S & Park, TW 1999, 'Natürlicher Verlauf der HPV-Infektion. Nutzen der HPV-Analytik in der Zervixdiagnostik', PATHOLOGE, vol. 20, no. 1, pp. 15-24.

APA

Milde-Langosch, K., Riethdorf, S., & Park, T. W. (1999). Natürlicher Verlauf der HPV-Infektion. Nutzen der HPV-Analytik in der Zervixdiagnostik. PATHOLOGE, 20(1), 15-24.

Vancouver

Milde-Langosch K, Riethdorf S, Park TW. Natürlicher Verlauf der HPV-Infektion. Nutzen der HPV-Analytik in der Zervixdiagnostik. PATHOLOGE. 1999 Jan;20(1):15-24.

Bibtex

@article{01806dbafa62400b977a5137a834ac1b,
title = "Nat{\"u}rlicher Verlauf der HPV-Infektion. Nutzen der HPV-Analytik in der Zervixdiagnostik",
abstract = "Cervical carcinomas and their precursors (cervical dysplasia, CIN1-3) are associated with human papillomavirus (HPV) infections. Epidemiological and in vitro-studies have shown that some of the genital HPV types, the high risk-types 16, 18, 31 etc., code for proteins (E6/E7) which strongly influence the cell cycle and genome stability. Progression from weak to severe dysplasia and to invasive cancer is associated with increasing expression of these viral oncogenes. Which additional cofactors contribute to progression of some dysplasias to carcinomas is still a matter of investigation. Recent results point to genetic predisposition (p53 polymorphism), cellular immune reaction, and cytokine expression. For HPV detection in cervical swabs and biopsies two highly sensitive and reliable systems (PCR, Hybrid Capture system) are available. Although classical histological methods are sufficient for the diagnosis of high-grade lesions and invasive cancer, HPV testing might give valuable diagnostic and prognostic clues especially in cases of unclear cytology (ASCUS) or weak dysplasia.",
keywords = "Biopsy, Cell Transformation, Neoplastic, Cervical Intraepithelial Neoplasia, Cervix Uteri, Female, Humans, Papillomaviridae, Papillomavirus Infections, Precancerous Conditions, Risk Factors, Tumor Virus Infections, Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, Virulence",
author = "K Milde-Langosch and S Riethdorf and Park, {T W}",
year = "1999",
month = jan,
language = "Deutsch",
volume = "20",
pages = "15--24",
journal = "PATHOLOGE",
issn = "0172-8113",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Natürlicher Verlauf der HPV-Infektion. Nutzen der HPV-Analytik in der Zervixdiagnostik

AU - Milde-Langosch, K

AU - Riethdorf, S

AU - Park, T W

PY - 1999/1

Y1 - 1999/1

N2 - Cervical carcinomas and their precursors (cervical dysplasia, CIN1-3) are associated with human papillomavirus (HPV) infections. Epidemiological and in vitro-studies have shown that some of the genital HPV types, the high risk-types 16, 18, 31 etc., code for proteins (E6/E7) which strongly influence the cell cycle and genome stability. Progression from weak to severe dysplasia and to invasive cancer is associated with increasing expression of these viral oncogenes. Which additional cofactors contribute to progression of some dysplasias to carcinomas is still a matter of investigation. Recent results point to genetic predisposition (p53 polymorphism), cellular immune reaction, and cytokine expression. For HPV detection in cervical swabs and biopsies two highly sensitive and reliable systems (PCR, Hybrid Capture system) are available. Although classical histological methods are sufficient for the diagnosis of high-grade lesions and invasive cancer, HPV testing might give valuable diagnostic and prognostic clues especially in cases of unclear cytology (ASCUS) or weak dysplasia.

AB - Cervical carcinomas and their precursors (cervical dysplasia, CIN1-3) are associated with human papillomavirus (HPV) infections. Epidemiological and in vitro-studies have shown that some of the genital HPV types, the high risk-types 16, 18, 31 etc., code for proteins (E6/E7) which strongly influence the cell cycle and genome stability. Progression from weak to severe dysplasia and to invasive cancer is associated with increasing expression of these viral oncogenes. Which additional cofactors contribute to progression of some dysplasias to carcinomas is still a matter of investigation. Recent results point to genetic predisposition (p53 polymorphism), cellular immune reaction, and cytokine expression. For HPV detection in cervical swabs and biopsies two highly sensitive and reliable systems (PCR, Hybrid Capture system) are available. Although classical histological methods are sufficient for the diagnosis of high-grade lesions and invasive cancer, HPV testing might give valuable diagnostic and prognostic clues especially in cases of unclear cytology (ASCUS) or weak dysplasia.

KW - Biopsy

KW - Cell Transformation, Neoplastic

KW - Cervical Intraepithelial Neoplasia

KW - Cervix Uteri

KW - Female

KW - Humans

KW - Papillomaviridae

KW - Papillomavirus Infections

KW - Precancerous Conditions

KW - Risk Factors

KW - Tumor Virus Infections

KW - Uterine Cervical Dysplasia

KW - Uterine Cervical Neoplasms

KW - Virulence

M3 - SCORING: Zeitschriftenaufsatz

C2 - 10091228

VL - 20

SP - 15

EP - 24

JO - PATHOLOGE

JF - PATHOLOGE

SN - 0172-8113

IS - 1

ER -