Natürlicher Verlauf der HPV-Infektion. Nutzen der HPV-Analytik in der Zervixdiagnostik
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Natürlicher Verlauf der HPV-Infektion. Nutzen der HPV-Analytik in der Zervixdiagnostik. / Milde-Langosch, K; Riethdorf, S; Park, T W.
in: PATHOLOGE, Jahrgang 20, Nr. 1, 01.1999, S. 15-24.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Natürlicher Verlauf der HPV-Infektion. Nutzen der HPV-Analytik in der Zervixdiagnostik
AU - Milde-Langosch, K
AU - Riethdorf, S
AU - Park, T W
PY - 1999/1
Y1 - 1999/1
N2 - Cervical carcinomas and their precursors (cervical dysplasia, CIN1-3) are associated with human papillomavirus (HPV) infections. Epidemiological and in vitro-studies have shown that some of the genital HPV types, the high risk-types 16, 18, 31 etc., code for proteins (E6/E7) which strongly influence the cell cycle and genome stability. Progression from weak to severe dysplasia and to invasive cancer is associated with increasing expression of these viral oncogenes. Which additional cofactors contribute to progression of some dysplasias to carcinomas is still a matter of investigation. Recent results point to genetic predisposition (p53 polymorphism), cellular immune reaction, and cytokine expression. For HPV detection in cervical swabs and biopsies two highly sensitive and reliable systems (PCR, Hybrid Capture system) are available. Although classical histological methods are sufficient for the diagnosis of high-grade lesions and invasive cancer, HPV testing might give valuable diagnostic and prognostic clues especially in cases of unclear cytology (ASCUS) or weak dysplasia.
AB - Cervical carcinomas and their precursors (cervical dysplasia, CIN1-3) are associated with human papillomavirus (HPV) infections. Epidemiological and in vitro-studies have shown that some of the genital HPV types, the high risk-types 16, 18, 31 etc., code for proteins (E6/E7) which strongly influence the cell cycle and genome stability. Progression from weak to severe dysplasia and to invasive cancer is associated with increasing expression of these viral oncogenes. Which additional cofactors contribute to progression of some dysplasias to carcinomas is still a matter of investigation. Recent results point to genetic predisposition (p53 polymorphism), cellular immune reaction, and cytokine expression. For HPV detection in cervical swabs and biopsies two highly sensitive and reliable systems (PCR, Hybrid Capture system) are available. Although classical histological methods are sufficient for the diagnosis of high-grade lesions and invasive cancer, HPV testing might give valuable diagnostic and prognostic clues especially in cases of unclear cytology (ASCUS) or weak dysplasia.
KW - Biopsy
KW - Cell Transformation, Neoplastic
KW - Cervical Intraepithelial Neoplasia
KW - Cervix Uteri
KW - Female
KW - Humans
KW - Papillomaviridae
KW - Papillomavirus Infections
KW - Precancerous Conditions
KW - Risk Factors
KW - Tumor Virus Infections
KW - Uterine Cervical Dysplasia
KW - Uterine Cervical Neoplasms
KW - Virulence
M3 - SCORING: Zeitschriftenaufsatz
C2 - 10091228
VL - 20
SP - 15
EP - 24
JO - PATHOLOGE
JF - PATHOLOGE
SN - 0172-8113
IS - 1
ER -