NAADP Signaling: New Kids on the Block
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NAADP Signaling: New Kids on the Block. / Guse, Andreas H.
In: CELLS-BASEL, Vol. 11, No. 6, 1054, 21.03.2022.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
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TY - JOUR
T1 - NAADP Signaling: New Kids on the Block
AU - Guse, Andreas H
PY - 2022/3/21
Y1 - 2022/3/21
N2 - Nicotinic acid adenine dinucleotide phosphate (NAADP) is a universal Ca2+ mobilizing second messenger essential for initiation of Ca2+ signaling. Recently, novel molecular mechanisms of both its rapid formation upon receptor stimulation and its mode of action were discovered. Dual NADPH oxidase 2 (DUOX2) and hematological and neurological expressed 1-like protein (HN1L)/Jupiter microtubule-associated homolog 2 (JPT2) were discovered as NAADP-forming enzyme and NAADP receptor/binding protein-the new kids on the block. These novel aspects are reviewed and integrated into the previous view of NAADP signaling.
AB - Nicotinic acid adenine dinucleotide phosphate (NAADP) is a universal Ca2+ mobilizing second messenger essential for initiation of Ca2+ signaling. Recently, novel molecular mechanisms of both its rapid formation upon receptor stimulation and its mode of action were discovered. Dual NADPH oxidase 2 (DUOX2) and hematological and neurological expressed 1-like protein (HN1L)/Jupiter microtubule-associated homolog 2 (JPT2) were discovered as NAADP-forming enzyme and NAADP receptor/binding protein-the new kids on the block. These novel aspects are reviewed and integrated into the previous view of NAADP signaling.
KW - Calcium/metabolism
KW - Calcium Signaling
KW - Carrier Proteins/metabolism
KW - NADP/analogs & derivatives
KW - Second Messenger Systems
U2 - 10.3390/cells11061054
DO - 10.3390/cells11061054
M3 - Other (editorial matter etc.)
C2 - 35326505
VL - 11
JO - CELLS-BASEL
JF - CELLS-BASEL
SN - 2073-4409
IS - 6
M1 - 1054
ER -