NAADP: From Discovery to Mechanism

Timothy F Walseth; Andreas H Guse

doi:10.3389/fimmu.2021.703326

NAADP: From Discovery to Mechanism

Standard

NAADP: From Discovery to Mechanism. / Walseth, Timothy F; Guse, Andreas H.

In: FRONT IMMUNOL, Vol. 12, 2021, p. 703326.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Walseth, TF & Guse, AH 2021, 'NAADP: From Discovery to Mechanism', FRONT IMMUNOL, vol. 12, pp. 703326. https://doi.org/10.3389/fimmu.2021.703326

APA

Walseth, T. F., & Guse, A. H. (2021). NAADP: From Discovery to Mechanism. FRONT IMMUNOL, 12, 703326. https://doi.org/10.3389/fimmu.2021.703326

Vancouver

Walseth TF, Guse AH. NAADP: From Discovery to Mechanism. FRONT IMMUNOL. 2021;12:703326. https://doi.org/10.3389/fimmu.2021.703326

Bibtex

@article{5e0abcb0728e4807b4f76dddcadab79c,

title = "NAADP: From Discovery to Mechanism",

abstract = "Nicotinic acid adenine dinucleotide 2'-phosphate (NAADP) is a naturally occurring nucleotide that has been shown to be involved in the release of Ca2+ from intracellular stores in a wide variety of cell types, tissues and organisms. Current evidence suggests that NAADP may function as a trigger to initiate a Ca2+ signal that is then amplified by other Ca2+ release mechanisms. A fundamental question that remains unanswered is the identity of the NAADP receptor. Our recent studies have identified HN1L/JPT2 as a high affinity NAADP binding protein that is essential for the modulation of Ca2+ channels.",

keywords = "Animals, Calcium Channels/immunology, Calcium Signaling/immunology, Calcium/immunology, Humans, Microtubule-Associated Proteins/immunology, NADP/analogs & derivatives",

author = "Walseth, {Timothy F} and Guse, {Andreas H}",

note = "Copyright {\textcopyright} 2021 Walseth and Guse.",

year = "2021",

doi = "10.3389/fimmu.2021.703326",

language = "English",

volume = "12",

pages = "703326",

journal = "FRONT IMMUNOL",

issn = "1664-3224",

publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - NAADP: From Discovery to Mechanism

AU - Walseth, Timothy F

AU - Guse, Andreas H

PY - 2021

Y1 - 2021

N2 - Nicotinic acid adenine dinucleotide 2'-phosphate (NAADP) is a naturally occurring nucleotide that has been shown to be involved in the release of Ca2+ from intracellular stores in a wide variety of cell types, tissues and organisms. Current evidence suggests that NAADP may function as a trigger to initiate a Ca2+ signal that is then amplified by other Ca2+ release mechanisms. A fundamental question that remains unanswered is the identity of the NAADP receptor. Our recent studies have identified HN1L/JPT2 as a high affinity NAADP binding protein that is essential for the modulation of Ca2+ channels.

AB - Nicotinic acid adenine dinucleotide 2'-phosphate (NAADP) is a naturally occurring nucleotide that has been shown to be involved in the release of Ca2+ from intracellular stores in a wide variety of cell types, tissues and organisms. Current evidence suggests that NAADP may function as a trigger to initiate a Ca2+ signal that is then amplified by other Ca2+ release mechanisms. A fundamental question that remains unanswered is the identity of the NAADP receptor. Our recent studies have identified HN1L/JPT2 as a high affinity NAADP binding protein that is essential for the modulation of Ca2+ channels.

KW - Animals

KW - Calcium Channels/immunology

KW - Calcium Signaling/immunology

KW - Calcium/immunology

KW - Humans

KW - Microtubule-Associated Proteins/immunology

KW - NADP/analogs & derivatives

U2 - 10.3389/fimmu.2021.703326

DO - 10.3389/fimmu.2021.703326

M3 - SCORING: Review article

C2 - 34557192

VL - 12

SP - 703326

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

ER -