NAADP: From Discovery to Mechanism
Related Research units
Abstract
Nicotinic acid adenine dinucleotide 2'-phosphate (NAADP) is a naturally occurring nucleotide that has been shown to be involved in the release of Ca2+ from intracellular stores in a wide variety of cell types, tissues and organisms. Current evidence suggests that NAADP may function as a trigger to initiate a Ca2+ signal that is then amplified by other Ca2+ release mechanisms. A fundamental question that remains unanswered is the identity of the NAADP receptor. Our recent studies have identified HN1L/JPT2 as a high affinity NAADP binding protein that is essential for the modulation of Ca2+ channels.
Bibliographical data
Original language | English |
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ISSN | 1664-3224 |
DOIs | |
Publication status | Published - 2021 |
Comment Deanary
Copyright © 2021 Walseth and Guse.
PubMed | 34557192 |
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