Myeloid-derived suppressor cells and tumor escape from immune surveillance
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Myeloid-derived suppressor cells and tumor escape from immune surveillance. / Umansky, Viktor; Blattner, Carolin; Fleming, Viktor; Hu, Xiaoying; Gebhardt, Christoffer; Altevogt, Peter; Utikal, Jochen.
In: SEMIN IMMUNOPATHOL, Vol. 39, No. 3, 04.2017, p. 295-305.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Myeloid-derived suppressor cells and tumor escape from immune surveillance
AU - Umansky, Viktor
AU - Blattner, Carolin
AU - Fleming, Viktor
AU - Hu, Xiaoying
AU - Gebhardt, Christoffer
AU - Altevogt, Peter
AU - Utikal, Jochen
PY - 2017/4
Y1 - 2017/4
N2 - Tumor progression is known to be supported by chronic inflammatory conditions developed in the tumor microenvironment. It is characterized by the long-term secretion of various inflammatory soluble factors (including cytokines, chemokines, growth factors, reactive oxygen and nitrogen species, prostaglandins, etc.) and strong leukocyte infiltration. Among leukocytes infiltrating tumors, myeloid-derived suppressor cells (MDSCs) represent one of the most important players mediating immunosuppression and supporting tumor escape. These cells can strongly inhibit antitumor immune reactions mediated by T cells and NK cells. Moreover, MDSCs are generated, recruited to the tumor site, and activated not only under the influence of soluble inflammatory mediators but also due to extracellular vesicles (EVs) secreted by tumor cells. EVs play a key role in the formation of MDSCs via the conversion of normal myeloid cells and altering the normal myelopoiesis. In addition, EVs help create a suitable microenvironment for the metastatic process.
AB - Tumor progression is known to be supported by chronic inflammatory conditions developed in the tumor microenvironment. It is characterized by the long-term secretion of various inflammatory soluble factors (including cytokines, chemokines, growth factors, reactive oxygen and nitrogen species, prostaglandins, etc.) and strong leukocyte infiltration. Among leukocytes infiltrating tumors, myeloid-derived suppressor cells (MDSCs) represent one of the most important players mediating immunosuppression and supporting tumor escape. These cells can strongly inhibit antitumor immune reactions mediated by T cells and NK cells. Moreover, MDSCs are generated, recruited to the tumor site, and activated not only under the influence of soluble inflammatory mediators but also due to extracellular vesicles (EVs) secreted by tumor cells. EVs play a key role in the formation of MDSCs via the conversion of normal myeloid cells and altering the normal myelopoiesis. In addition, EVs help create a suitable microenvironment for the metastatic process.
KW - Animals
KW - Cell Differentiation
KW - Cell Movement
KW - Cell-Derived Microparticles
KW - Cytokines
KW - Extracellular Vesicles
KW - Humans
KW - Immunologic Surveillance
KW - Immunosuppression
KW - Inflammation Mediators
KW - Myeloid-Derived Suppressor Cells
KW - Neoplasms
KW - Signal Transduction
KW - Tumor Escape
KW - Tumor Microenvironment
KW - Journal Article
KW - Review
KW - Research Support, Non-U.S. Gov't
U2 - 10.1007/s00281-016-0597-6
DO - 10.1007/s00281-016-0597-6
M3 - SCORING: Review article
C2 - 27787613
VL - 39
SP - 295
EP - 305
JO - SEMIN IMMUNOPATHOL
JF - SEMIN IMMUNOPATHOL
SN - 1863-2297
IS - 3
ER -