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Myeloid-derived suppressor cells and tumor escape from immune surveillance

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Myeloid-derived suppressor cells and tumor escape from immune surveillance. / Umansky, Viktor; Blattner, Carolin; Fleming, Viktor; Hu, Xiaoying; Gebhardt, Christoffer; Altevogt, Peter; Utikal, Jochen.

in: SEMIN IMMUNOPATHOL, Jahrgang 39, Nr. 3, 04.2017, S. 295-305.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Umansky, V, Blattner, C, Fleming, V, Hu, X, Gebhardt, C, Altevogt, P & Utikal, J 2017, 'Myeloid-derived suppressor cells and tumor escape from immune surveillance', SEMIN IMMUNOPATHOL, Jg. 39, Nr. 3, S. 295-305. https://doi.org/10.1007/s00281-016-0597-6

APA

Umansky, V., Blattner, C., Fleming, V., Hu, X., Gebhardt, C., Altevogt, P., & Utikal, J. (2017). Myeloid-derived suppressor cells and tumor escape from immune surveillance. SEMIN IMMUNOPATHOL, 39(3), 295-305. https://doi.org/10.1007/s00281-016-0597-6

Vancouver

Umansky V, Blattner C, Fleming V, Hu X, Gebhardt C, Altevogt P et al. Myeloid-derived suppressor cells and tumor escape from immune surveillance. SEMIN IMMUNOPATHOL. 2017 Apr;39(3):295-305. https://doi.org/10.1007/s00281-016-0597-6

Bibtex

@article{20455316d6924ff69e7d30f34d4e4484,
title = "Myeloid-derived suppressor cells and tumor escape from immune surveillance",
abstract = "Tumor progression is known to be supported by chronic inflammatory conditions developed in the tumor microenvironment. It is characterized by the long-term secretion of various inflammatory soluble factors (including cytokines, chemokines, growth factors, reactive oxygen and nitrogen species, prostaglandins, etc.) and strong leukocyte infiltration. Among leukocytes infiltrating tumors, myeloid-derived suppressor cells (MDSCs) represent one of the most important players mediating immunosuppression and supporting tumor escape. These cells can strongly inhibit antitumor immune reactions mediated by T cells and NK cells. Moreover, MDSCs are generated, recruited to the tumor site, and activated not only under the influence of soluble inflammatory mediators but also due to extracellular vesicles (EVs) secreted by tumor cells. EVs play a key role in the formation of MDSCs via the conversion of normal myeloid cells and altering the normal myelopoiesis. In addition, EVs help create a suitable microenvironment for the metastatic process.",
keywords = "Animals, Cell Differentiation, Cell Movement, Cell-Derived Microparticles, Cytokines, Extracellular Vesicles, Humans, Immunologic Surveillance, Immunosuppression, Inflammation Mediators, Myeloid-Derived Suppressor Cells, Neoplasms, Signal Transduction, Tumor Escape, Tumor Microenvironment, Journal Article, Review, Research Support, Non-U.S. Gov't",
author = "Viktor Umansky and Carolin Blattner and Viktor Fleming and Xiaoying Hu and Christoffer Gebhardt and Peter Altevogt and Jochen Utikal",
year = "2017",
month = apr,
doi = "10.1007/s00281-016-0597-6",
language = "English",
volume = "39",
pages = "295--305",
journal = "SEMIN IMMUNOPATHOL",
issn = "1863-2297",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Myeloid-derived suppressor cells and tumor escape from immune surveillance

AU - Umansky, Viktor

AU - Blattner, Carolin

AU - Fleming, Viktor

AU - Hu, Xiaoying

AU - Gebhardt, Christoffer

AU - Altevogt, Peter

AU - Utikal, Jochen

PY - 2017/4

Y1 - 2017/4

N2 - Tumor progression is known to be supported by chronic inflammatory conditions developed in the tumor microenvironment. It is characterized by the long-term secretion of various inflammatory soluble factors (including cytokines, chemokines, growth factors, reactive oxygen and nitrogen species, prostaglandins, etc.) and strong leukocyte infiltration. Among leukocytes infiltrating tumors, myeloid-derived suppressor cells (MDSCs) represent one of the most important players mediating immunosuppression and supporting tumor escape. These cells can strongly inhibit antitumor immune reactions mediated by T cells and NK cells. Moreover, MDSCs are generated, recruited to the tumor site, and activated not only under the influence of soluble inflammatory mediators but also due to extracellular vesicles (EVs) secreted by tumor cells. EVs play a key role in the formation of MDSCs via the conversion of normal myeloid cells and altering the normal myelopoiesis. In addition, EVs help create a suitable microenvironment for the metastatic process.

AB - Tumor progression is known to be supported by chronic inflammatory conditions developed in the tumor microenvironment. It is characterized by the long-term secretion of various inflammatory soluble factors (including cytokines, chemokines, growth factors, reactive oxygen and nitrogen species, prostaglandins, etc.) and strong leukocyte infiltration. Among leukocytes infiltrating tumors, myeloid-derived suppressor cells (MDSCs) represent one of the most important players mediating immunosuppression and supporting tumor escape. These cells can strongly inhibit antitumor immune reactions mediated by T cells and NK cells. Moreover, MDSCs are generated, recruited to the tumor site, and activated not only under the influence of soluble inflammatory mediators but also due to extracellular vesicles (EVs) secreted by tumor cells. EVs play a key role in the formation of MDSCs via the conversion of normal myeloid cells and altering the normal myelopoiesis. In addition, EVs help create a suitable microenvironment for the metastatic process.

KW - Animals

KW - Cell Differentiation

KW - Cell Movement

KW - Cell-Derived Microparticles

KW - Cytokines

KW - Extracellular Vesicles

KW - Humans

KW - Immunologic Surveillance

KW - Immunosuppression

KW - Inflammation Mediators

KW - Myeloid-Derived Suppressor Cells

KW - Neoplasms

KW - Signal Transduction

KW - Tumor Escape

KW - Tumor Microenvironment

KW - Journal Article

KW - Review

KW - Research Support, Non-U.S. Gov't

U2 - 10.1007/s00281-016-0597-6

DO - 10.1007/s00281-016-0597-6

M3 - SCORING: Review article

C2 - 27787613

VL - 39

SP - 295

EP - 305

JO - SEMIN IMMUNOPATHOL

JF - SEMIN IMMUNOPATHOL

SN - 1863-2297

IS - 3

ER -