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Multispectral optoacoustic tomography of systemic sclerosis

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Multispectral optoacoustic tomography of systemic sclerosis. / Masthoff, Max; Helfen, Anne; Claussen, Jing; Roll, Wolfgang; Karlas, Angelos; Becker, Heidemarie; Gabriëls, Gert; Riess, Jan; Heindel, Walter; Schäfers, Michael; Ntziachristos, Vasilis; Eisenblätter, Michel; Gerth, Ulrich; Wildgruber, Moritz.

In: J BIOPHOTONICS, Vol. 11, No. 11, 11.2018, p. e201800155.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Masthoff, M, Helfen, A, Claussen, J, Roll, W, Karlas, A, Becker, H, Gabriëls, G, Riess, J, Heindel, W, Schäfers, M, Ntziachristos, V, Eisenblätter, M, Gerth, U & Wildgruber, M 2018, 'Multispectral optoacoustic tomography of systemic sclerosis', J BIOPHOTONICS, vol. 11, no. 11, pp. e201800155. https://doi.org/10.1002/jbio.201800155

APA

Masthoff, M., Helfen, A., Claussen, J., Roll, W., Karlas, A., Becker, H., Gabriëls, G., Riess, J., Heindel, W., Schäfers, M., Ntziachristos, V., Eisenblätter, M., Gerth, U., & Wildgruber, M. (2018). Multispectral optoacoustic tomography of systemic sclerosis. J BIOPHOTONICS, 11(11), e201800155. https://doi.org/10.1002/jbio.201800155

Vancouver

Masthoff M, Helfen A, Claussen J, Roll W, Karlas A, Becker H et al. Multispectral optoacoustic tomography of systemic sclerosis. J BIOPHOTONICS. 2018 Nov;11(11):e201800155. https://doi.org/10.1002/jbio.201800155

Bibtex

@article{217ba294025c4895b7fbbbb8b88cf5a8,
title = "Multispectral optoacoustic tomography of systemic sclerosis",
abstract = "The study aimed to evaluate the clinical feasibility of hybrid ultrasound/multispectral optoacoustic tomography (MSOT) for assessing microvascular dysfunction in systemic sclerosis (SSc). A handheld US/MSOT imaging system was applied for imaging patients diagnosed with SSc (n = 7) and healthy volunteers (n = 8). Semiquantitative MSOT values for deoxygenated (HbR), oxygenated (HbO2 ) and total haemoglobin (HbT) were analysed for subcutaneous finger tissue of both hands (8 fingers per subject, 120 fingers in total) and used to assess disease activity (progressive vs stable). Grouped data were compared by one-way nested analysis of variance, Tukey post-hoc test as well as student's t test were used for statistical analysis.Subcutaneous finger tissue of patients with SSc provided significantly lower MSOT values for HbO2 (26.16 ± 0.71 vs 38.2 ± 1.54, P = .023) and HbT (55.92 ± 1.62 vs 72.46 ± 1.90, P = .018) compared to healthy volunteers. Patients with progressive SSc had significantly lower MSOT values compared to patients with stable disease and healthy volunteers.This pilot study shows the feasibility of MSOT imaging to resolve microvascular dysfunction in SSc as a marker of disease activity. By providing biological tissue properties not revealed by other imaging modalities, MSOT might help to grade SSc non-invasively and monitor early therapy response.",
keywords = "Adult, Aged, Case-Control Studies, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Photoacoustic Techniques, Scleroderma, Systemic/diagnostic imaging, Tomography",
author = "Max Masthoff and Anne Helfen and Jing Claussen and Wolfgang Roll and Angelos Karlas and Heidemarie Becker and Gert Gabri{\"e}ls and Jan Riess and Walter Heindel and Michael Sch{\"a}fers and Vasilis Ntziachristos and Michel Eisenbl{\"a}tter and Ulrich Gerth and Moritz Wildgruber",
note = "{\textcopyright} 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2018",
month = nov,
doi = "10.1002/jbio.201800155",
language = "English",
volume = "11",
pages = "e201800155",
journal = "J BIOPHOTONICS",
issn = "1864-063X",
publisher = "Wiley-VCH Verlag GmbH",
number = "11",

}

RIS

TY - JOUR

T1 - Multispectral optoacoustic tomography of systemic sclerosis

AU - Masthoff, Max

AU - Helfen, Anne

AU - Claussen, Jing

AU - Roll, Wolfgang

AU - Karlas, Angelos

AU - Becker, Heidemarie

AU - Gabriëls, Gert

AU - Riess, Jan

AU - Heindel, Walter

AU - Schäfers, Michael

AU - Ntziachristos, Vasilis

AU - Eisenblätter, Michel

AU - Gerth, Ulrich

AU - Wildgruber, Moritz

N1 - © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2018/11

Y1 - 2018/11

N2 - The study aimed to evaluate the clinical feasibility of hybrid ultrasound/multispectral optoacoustic tomography (MSOT) for assessing microvascular dysfunction in systemic sclerosis (SSc). A handheld US/MSOT imaging system was applied for imaging patients diagnosed with SSc (n = 7) and healthy volunteers (n = 8). Semiquantitative MSOT values for deoxygenated (HbR), oxygenated (HbO2 ) and total haemoglobin (HbT) were analysed for subcutaneous finger tissue of both hands (8 fingers per subject, 120 fingers in total) and used to assess disease activity (progressive vs stable). Grouped data were compared by one-way nested analysis of variance, Tukey post-hoc test as well as student's t test were used for statistical analysis.Subcutaneous finger tissue of patients with SSc provided significantly lower MSOT values for HbO2 (26.16 ± 0.71 vs 38.2 ± 1.54, P = .023) and HbT (55.92 ± 1.62 vs 72.46 ± 1.90, P = .018) compared to healthy volunteers. Patients with progressive SSc had significantly lower MSOT values compared to patients with stable disease and healthy volunteers.This pilot study shows the feasibility of MSOT imaging to resolve microvascular dysfunction in SSc as a marker of disease activity. By providing biological tissue properties not revealed by other imaging modalities, MSOT might help to grade SSc non-invasively and monitor early therapy response.

AB - The study aimed to evaluate the clinical feasibility of hybrid ultrasound/multispectral optoacoustic tomography (MSOT) for assessing microvascular dysfunction in systemic sclerosis (SSc). A handheld US/MSOT imaging system was applied for imaging patients diagnosed with SSc (n = 7) and healthy volunteers (n = 8). Semiquantitative MSOT values for deoxygenated (HbR), oxygenated (HbO2 ) and total haemoglobin (HbT) were analysed for subcutaneous finger tissue of both hands (8 fingers per subject, 120 fingers in total) and used to assess disease activity (progressive vs stable). Grouped data were compared by one-way nested analysis of variance, Tukey post-hoc test as well as student's t test were used for statistical analysis.Subcutaneous finger tissue of patients with SSc provided significantly lower MSOT values for HbO2 (26.16 ± 0.71 vs 38.2 ± 1.54, P = .023) and HbT (55.92 ± 1.62 vs 72.46 ± 1.90, P = .018) compared to healthy volunteers. Patients with progressive SSc had significantly lower MSOT values compared to patients with stable disease and healthy volunteers.This pilot study shows the feasibility of MSOT imaging to resolve microvascular dysfunction in SSc as a marker of disease activity. By providing biological tissue properties not revealed by other imaging modalities, MSOT might help to grade SSc non-invasively and monitor early therapy response.

KW - Adult

KW - Aged

KW - Case-Control Studies

KW - Female

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Male

KW - Middle Aged

KW - Photoacoustic Techniques

KW - Scleroderma, Systemic/diagnostic imaging

KW - Tomography

U2 - 10.1002/jbio.201800155

DO - 10.1002/jbio.201800155

M3 - SCORING: Journal article

C2 - 29974645

VL - 11

SP - e201800155

JO - J BIOPHOTONICS

JF - J BIOPHOTONICS

SN - 1864-063X

IS - 11

ER -