Multispectral optoacoustic tomography of systemic sclerosis
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Multispectral optoacoustic tomography of systemic sclerosis. / Masthoff, Max; Helfen, Anne; Claussen, Jing; Roll, Wolfgang; Karlas, Angelos; Becker, Heidemarie; Gabriëls, Gert; Riess, Jan; Heindel, Walter; Schäfers, Michael; Ntziachristos, Vasilis; Eisenblätter, Michel; Gerth, Ulrich; Wildgruber, Moritz.
in: J BIOPHOTONICS, Jahrgang 11, Nr. 11, 11.2018, S. e201800155.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Multispectral optoacoustic tomography of systemic sclerosis
AU - Masthoff, Max
AU - Helfen, Anne
AU - Claussen, Jing
AU - Roll, Wolfgang
AU - Karlas, Angelos
AU - Becker, Heidemarie
AU - Gabriëls, Gert
AU - Riess, Jan
AU - Heindel, Walter
AU - Schäfers, Michael
AU - Ntziachristos, Vasilis
AU - Eisenblätter, Michel
AU - Gerth, Ulrich
AU - Wildgruber, Moritz
N1 - © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2018/11
Y1 - 2018/11
N2 - The study aimed to evaluate the clinical feasibility of hybrid ultrasound/multispectral optoacoustic tomography (MSOT) for assessing microvascular dysfunction in systemic sclerosis (SSc). A handheld US/MSOT imaging system was applied for imaging patients diagnosed with SSc (n = 7) and healthy volunteers (n = 8). Semiquantitative MSOT values for deoxygenated (HbR), oxygenated (HbO2 ) and total haemoglobin (HbT) were analysed for subcutaneous finger tissue of both hands (8 fingers per subject, 120 fingers in total) and used to assess disease activity (progressive vs stable). Grouped data were compared by one-way nested analysis of variance, Tukey post-hoc test as well as student's t test were used for statistical analysis.Subcutaneous finger tissue of patients with SSc provided significantly lower MSOT values for HbO2 (26.16 ± 0.71 vs 38.2 ± 1.54, P = .023) and HbT (55.92 ± 1.62 vs 72.46 ± 1.90, P = .018) compared to healthy volunteers. Patients with progressive SSc had significantly lower MSOT values compared to patients with stable disease and healthy volunteers.This pilot study shows the feasibility of MSOT imaging to resolve microvascular dysfunction in SSc as a marker of disease activity. By providing biological tissue properties not revealed by other imaging modalities, MSOT might help to grade SSc non-invasively and monitor early therapy response.
AB - The study aimed to evaluate the clinical feasibility of hybrid ultrasound/multispectral optoacoustic tomography (MSOT) for assessing microvascular dysfunction in systemic sclerosis (SSc). A handheld US/MSOT imaging system was applied for imaging patients diagnosed with SSc (n = 7) and healthy volunteers (n = 8). Semiquantitative MSOT values for deoxygenated (HbR), oxygenated (HbO2 ) and total haemoglobin (HbT) were analysed for subcutaneous finger tissue of both hands (8 fingers per subject, 120 fingers in total) and used to assess disease activity (progressive vs stable). Grouped data were compared by one-way nested analysis of variance, Tukey post-hoc test as well as student's t test were used for statistical analysis.Subcutaneous finger tissue of patients with SSc provided significantly lower MSOT values for HbO2 (26.16 ± 0.71 vs 38.2 ± 1.54, P = .023) and HbT (55.92 ± 1.62 vs 72.46 ± 1.90, P = .018) compared to healthy volunteers. Patients with progressive SSc had significantly lower MSOT values compared to patients with stable disease and healthy volunteers.This pilot study shows the feasibility of MSOT imaging to resolve microvascular dysfunction in SSc as a marker of disease activity. By providing biological tissue properties not revealed by other imaging modalities, MSOT might help to grade SSc non-invasively and monitor early therapy response.
KW - Adult
KW - Aged
KW - Case-Control Studies
KW - Female
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Male
KW - Middle Aged
KW - Photoacoustic Techniques
KW - Scleroderma, Systemic/diagnostic imaging
KW - Tomography
U2 - 10.1002/jbio.201800155
DO - 10.1002/jbio.201800155
M3 - SCORING: Journal article
C2 - 29974645
VL - 11
SP - e201800155
JO - J BIOPHOTONICS
JF - J BIOPHOTONICS
SN - 1864-063X
IS - 11
ER -