Multiple sclerosis: doubling down on MHC
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Multiple sclerosis: doubling down on MHC. / Martin, Roland; Sospedra, Mireia; Eiermann, Thomas; Olsson, Tomas.
In: TRENDS GENET, Vol. 37, No. 9, 09.2021, p. 784-797.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Multiple sclerosis: doubling down on MHC
AU - Martin, Roland
AU - Sospedra, Mireia
AU - Eiermann, Thomas
AU - Olsson, Tomas
N1 - Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
PY - 2021/9
Y1 - 2021/9
N2 - Human leukocyte antigen (HLA)-encoded surface molecules present antigenic peptides to T lymphocytes and play a key role in adaptive immune responses. Besides their physiological role of defending the host against infectious pathogens, specific alleles serve as genetic risk factors for autoimmune diseases. For multiple sclerosis (MS), an autoimmune disease that affects the brain and spinal cord, an association with the HLA-DR15 haplotype was described in the early 1970s. This short opinion piece discusses the difficulties of disentangling the details of this association and recent observations about the functional involvement of not only one, but also the second gene of the HLA-DR15 haplotype. This information is not only important for understanding the pathomechanism of MS, but also for antigen-specific therapies.
AB - Human leukocyte antigen (HLA)-encoded surface molecules present antigenic peptides to T lymphocytes and play a key role in adaptive immune responses. Besides their physiological role of defending the host against infectious pathogens, specific alleles serve as genetic risk factors for autoimmune diseases. For multiple sclerosis (MS), an autoimmune disease that affects the brain and spinal cord, an association with the HLA-DR15 haplotype was described in the early 1970s. This short opinion piece discusses the difficulties of disentangling the details of this association and recent observations about the functional involvement of not only one, but also the second gene of the HLA-DR15 haplotype. This information is not only important for understanding the pathomechanism of MS, but also for antigen-specific therapies.
U2 - 10.1016/j.tig.2021.04.012
DO - 10.1016/j.tig.2021.04.012
M3 - SCORING: Review article
C2 - 34006391
VL - 37
SP - 784
EP - 797
JO - TRENDS GENET
JF - TRENDS GENET
SN - 0168-9525
IS - 9
ER -