Multiple sclerosis: doubling down on MHC

Roland Martin; Mireia Sospedra; Thomas Eiermann; Tomas Olsson

doi:10.1016/j.tig.2021.04.012

Multiple sclerosis: doubling down on MHC

Standard

Multiple sclerosis: doubling down on MHC. / Martin, Roland; Sospedra, Mireia; Eiermann, Thomas; Olsson, Tomas.

in: TRENDS GENET, Jahrgang 37, Nr. 9, 09.2021, S. 784-797.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Martin, R, Sospedra, M, Eiermann, T & Olsson, T 2021, 'Multiple sclerosis: doubling down on MHC', TRENDS GENET, Jg. 37, Nr. 9, S. 784-797. https://doi.org/10.1016/j.tig.2021.04.012

APA

Martin, R., Sospedra, M., Eiermann, T., & Olsson, T. (2021). Multiple sclerosis: doubling down on MHC. TRENDS GENET, 37(9), 784-797. https://doi.org/10.1016/j.tig.2021.04.012

Vancouver

Martin R, Sospedra M, Eiermann T, Olsson T. Multiple sclerosis: doubling down on MHC. TRENDS GENET. 2021 Sep;37(9):784-797. https://doi.org/10.1016/j.tig.2021.04.012

Bibtex

@article{faf090e98dee497c86056d13b235b18d,

title = "Multiple sclerosis: doubling down on MHC",

abstract = "Human leukocyte antigen (HLA)-encoded surface molecules present antigenic peptides to T lymphocytes and play a key role in adaptive immune responses. Besides their physiological role of defending the host against infectious pathogens, specific alleles serve as genetic risk factors for autoimmune diseases. For multiple sclerosis (MS), an autoimmune disease that affects the brain and spinal cord, an association with the HLA-DR15 haplotype was described in the early 1970s. This short opinion piece discusses the difficulties of disentangling the details of this association and recent observations about the functional involvement of not only one, but also the second gene of the HLA-DR15 haplotype. This information is not only important for understanding the pathomechanism of MS, but also for antigen-specific therapies.",

author = "Roland Martin and Mireia Sospedra and Thomas Eiermann and Tomas Olsson",

year = "2021",

month = sep,

doi = "10.1016/j.tig.2021.04.012",

language = "English",

volume = "37",

pages = "784--797",

journal = "TRENDS GENET",

issn = "0168-9525",

publisher = "Elsevier Limited",

number = "9",

}

RIS

TY - JOUR

T1 - Multiple sclerosis: doubling down on MHC

AU - Martin, Roland

AU - Sospedra, Mireia

AU - Eiermann, Thomas

AU - Olsson, Tomas

PY - 2021/9

Y1 - 2021/9

N2 - Human leukocyte antigen (HLA)-encoded surface molecules present antigenic peptides to T lymphocytes and play a key role in adaptive immune responses. Besides their physiological role of defending the host against infectious pathogens, specific alleles serve as genetic risk factors for autoimmune diseases. For multiple sclerosis (MS), an autoimmune disease that affects the brain and spinal cord, an association with the HLA-DR15 haplotype was described in the early 1970s. This short opinion piece discusses the difficulties of disentangling the details of this association and recent observations about the functional involvement of not only one, but also the second gene of the HLA-DR15 haplotype. This information is not only important for understanding the pathomechanism of MS, but also for antigen-specific therapies.

AB - Human leukocyte antigen (HLA)-encoded surface molecules present antigenic peptides to T lymphocytes and play a key role in adaptive immune responses. Besides their physiological role of defending the host against infectious pathogens, specific alleles serve as genetic risk factors for autoimmune diseases. For multiple sclerosis (MS), an autoimmune disease that affects the brain and spinal cord, an association with the HLA-DR15 haplotype was described in the early 1970s. This short opinion piece discusses the difficulties of disentangling the details of this association and recent observations about the functional involvement of not only one, but also the second gene of the HLA-DR15 haplotype. This information is not only important for understanding the pathomechanism of MS, but also for antigen-specific therapies.

U2 - 10.1016/j.tig.2021.04.012

DO - 10.1016/j.tig.2021.04.012

M3 - SCORING: Review article

C2 - 34006391

VL - 37

SP - 784

EP - 797

JO - TRENDS GENET

JF - TRENDS GENET

SN - 0168-9525

IS - 9

ER -