Multiparameter flow cytometry in the differential diagnosis of aberrant T-cell clones of unclear significance
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Multiparameter flow cytometry in the differential diagnosis of aberrant T-cell clones of unclear significance. / Flammiger, Anna; Bacher, Ulrike; Christopeit, Maximilian; Horn, Christiane; Rühlmann, Elke; Kluge, Katrin; Vettorazzi, Eik; Bokemeyer, Carsten; Binder, Mascha.
In: LEUKEMIA LYMPHOMA, Vol. 56, No. 3, 2014, p. 639-644.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Multiparameter flow cytometry in the differential diagnosis of aberrant T-cell clones of unclear significance
AU - Flammiger, Anna
AU - Bacher, Ulrike
AU - Christopeit, Maximilian
AU - Horn, Christiane
AU - Rühlmann, Elke
AU - Kluge, Katrin
AU - Vettorazzi, Eik
AU - Bokemeyer, Carsten
AU - Binder, Mascha
PY - 2014
Y1 - 2014
N2 - ABSTRACT Immunophenotypic distinction between neoplastic and reactive T-cell clones can be challenging as peripheral T-cell lymphomas (PTCL) lack an immunophenotypic marker of clonality. Systematic screening of 10,510 cases analyzed by immunophenotyping at our institution between 2006 and 2012 resulted in 49 cases with aberrant T-cell populations of unclear significance. Review of patient charts allowed to assign these cases to three categories: In 21 cases, PTCL could later be confirmed by complementary diagnostics ("PTCL group"). In 20 cases, follow-up confirmed the reactive nature of the aberrant T-cells ("non-PTCL group"). Eight cases remained of unclear significance. Neither the population size nor the number of aberrant markers differed significantly between the PTCL and non-PTCL group. Only loss of CD7 was found significantly more often in PTCL than in non-PTCL patients (p=0.037). Our data shows that aberrant T-cell populations need to be interpreted in the clinicopathological context, as reactive and neoplastic phenotypes largely overlap.
AB - ABSTRACT Immunophenotypic distinction between neoplastic and reactive T-cell clones can be challenging as peripheral T-cell lymphomas (PTCL) lack an immunophenotypic marker of clonality. Systematic screening of 10,510 cases analyzed by immunophenotyping at our institution between 2006 and 2012 resulted in 49 cases with aberrant T-cell populations of unclear significance. Review of patient charts allowed to assign these cases to three categories: In 21 cases, PTCL could later be confirmed by complementary diagnostics ("PTCL group"). In 20 cases, follow-up confirmed the reactive nature of the aberrant T-cells ("non-PTCL group"). Eight cases remained of unclear significance. Neither the population size nor the number of aberrant markers differed significantly between the PTCL and non-PTCL group. Only loss of CD7 was found significantly more often in PTCL than in non-PTCL patients (p=0.037). Our data shows that aberrant T-cell populations need to be interpreted in the clinicopathological context, as reactive and neoplastic phenotypes largely overlap.
U2 - 10.3109/10428194.2014.926347
DO - 10.3109/10428194.2014.926347
M3 - SCORING: Journal article
C2 - 24882255
VL - 56
SP - 639
EP - 644
JO - LEUKEMIA LYMPHOMA
JF - LEUKEMIA LYMPHOMA
SN - 1042-8194
IS - 3
ER -