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Multiparameter flow cytometry in the differential diagnosis of aberrant T-cell clones of unclear significance

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Multiparameter flow cytometry in the differential diagnosis of aberrant T-cell clones of unclear significance. / Flammiger, Anna; Bacher, Ulrike; Christopeit, Maximilian; Horn, Christiane; Rühlmann, Elke; Kluge, Katrin; Vettorazzi, Eik; Bokemeyer, Carsten; Binder, Mascha.

in: LEUKEMIA LYMPHOMA, Jahrgang 56, Nr. 3, 2014, S. 639-644.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Flammiger, A, Bacher, U, Christopeit, M, Horn, C, Rühlmann, E, Kluge, K, Vettorazzi, E, Bokemeyer, C & Binder, M 2014, 'Multiparameter flow cytometry in the differential diagnosis of aberrant T-cell clones of unclear significance', LEUKEMIA LYMPHOMA, Jg. 56, Nr. 3, S. 639-644. https://doi.org/10.3109/10428194.2014.926347

APA

Flammiger, A., Bacher, U., Christopeit, M., Horn, C., Rühlmann, E., Kluge, K., Vettorazzi, E., Bokemeyer, C., & Binder, M. (2014). Multiparameter flow cytometry in the differential diagnosis of aberrant T-cell clones of unclear significance. LEUKEMIA LYMPHOMA, 56(3), 639-644. https://doi.org/10.3109/10428194.2014.926347

Vancouver

Flammiger A, Bacher U, Christopeit M, Horn C, Rühlmann E, Kluge K et al. Multiparameter flow cytometry in the differential diagnosis of aberrant T-cell clones of unclear significance. LEUKEMIA LYMPHOMA. 2014;56(3):639-644. https://doi.org/10.3109/10428194.2014.926347

Bibtex

@article{f714b3865e464ce8886f6897a662989d,
title = "Multiparameter flow cytometry in the differential diagnosis of aberrant T-cell clones of unclear significance",
abstract = "ABSTRACT Immunophenotypic distinction between neoplastic and reactive T-cell clones can be challenging as peripheral T-cell lymphomas (PTCL) lack an immunophenotypic marker of clonality. Systematic screening of 10,510 cases analyzed by immunophenotyping at our institution between 2006 and 2012 resulted in 49 cases with aberrant T-cell populations of unclear significance. Review of patient charts allowed to assign these cases to three categories: In 21 cases, PTCL could later be confirmed by complementary diagnostics ({"}PTCL group{"}). In 20 cases, follow-up confirmed the reactive nature of the aberrant T-cells ({"}non-PTCL group{"}). Eight cases remained of unclear significance. Neither the population size nor the number of aberrant markers differed significantly between the PTCL and non-PTCL group. Only loss of CD7 was found significantly more often in PTCL than in non-PTCL patients (p=0.037). Our data shows that aberrant T-cell populations need to be interpreted in the clinicopathological context, as reactive and neoplastic phenotypes largely overlap.",
author = "Anna Flammiger and Ulrike Bacher and Maximilian Christopeit and Christiane Horn and Elke R{\"u}hlmann and Katrin Kluge and Eik Vettorazzi and Carsten Bokemeyer and Mascha Binder",
year = "2014",
doi = "10.3109/10428194.2014.926347",
language = "English",
volume = "56",
pages = "639--644",
journal = "LEUKEMIA LYMPHOMA",
issn = "1042-8194",
publisher = "informa healthcare",
number = "3",

}

RIS

TY - JOUR

T1 - Multiparameter flow cytometry in the differential diagnosis of aberrant T-cell clones of unclear significance

AU - Flammiger, Anna

AU - Bacher, Ulrike

AU - Christopeit, Maximilian

AU - Horn, Christiane

AU - Rühlmann, Elke

AU - Kluge, Katrin

AU - Vettorazzi, Eik

AU - Bokemeyer, Carsten

AU - Binder, Mascha

PY - 2014

Y1 - 2014

N2 - ABSTRACT Immunophenotypic distinction between neoplastic and reactive T-cell clones can be challenging as peripheral T-cell lymphomas (PTCL) lack an immunophenotypic marker of clonality. Systematic screening of 10,510 cases analyzed by immunophenotyping at our institution between 2006 and 2012 resulted in 49 cases with aberrant T-cell populations of unclear significance. Review of patient charts allowed to assign these cases to three categories: In 21 cases, PTCL could later be confirmed by complementary diagnostics ("PTCL group"). In 20 cases, follow-up confirmed the reactive nature of the aberrant T-cells ("non-PTCL group"). Eight cases remained of unclear significance. Neither the population size nor the number of aberrant markers differed significantly between the PTCL and non-PTCL group. Only loss of CD7 was found significantly more often in PTCL than in non-PTCL patients (p=0.037). Our data shows that aberrant T-cell populations need to be interpreted in the clinicopathological context, as reactive and neoplastic phenotypes largely overlap.

AB - ABSTRACT Immunophenotypic distinction between neoplastic and reactive T-cell clones can be challenging as peripheral T-cell lymphomas (PTCL) lack an immunophenotypic marker of clonality. Systematic screening of 10,510 cases analyzed by immunophenotyping at our institution between 2006 and 2012 resulted in 49 cases with aberrant T-cell populations of unclear significance. Review of patient charts allowed to assign these cases to three categories: In 21 cases, PTCL could later be confirmed by complementary diagnostics ("PTCL group"). In 20 cases, follow-up confirmed the reactive nature of the aberrant T-cells ("non-PTCL group"). Eight cases remained of unclear significance. Neither the population size nor the number of aberrant markers differed significantly between the PTCL and non-PTCL group. Only loss of CD7 was found significantly more often in PTCL than in non-PTCL patients (p=0.037). Our data shows that aberrant T-cell populations need to be interpreted in the clinicopathological context, as reactive and neoplastic phenotypes largely overlap.

U2 - 10.3109/10428194.2014.926347

DO - 10.3109/10428194.2014.926347

M3 - SCORING: Journal article

C2 - 24882255

VL - 56

SP - 639

EP - 644

JO - LEUKEMIA LYMPHOMA

JF - LEUKEMIA LYMPHOMA

SN - 1042-8194

IS - 3

ER -