MT1-MMP: Endosomal delivery drives breast cancer metastasis
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MT1-MMP: Endosomal delivery drives breast cancer metastasis. / Linder, Stefan.
In: J CELL BIOL, Vol. 211, No. 2, 26.10.2015, p. 215-7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - MT1-MMP: Endosomal delivery drives breast cancer metastasis
AU - Linder, Stefan
N1 - © 2015 Linder.
PY - 2015/10/26
Y1 - 2015/10/26
N2 - The membrane-tethered membrane type 1-matrix metalloproteinase (MT1-MMP) mediates proteolysis-based invasive tumor growth. In this issue, Marchesin et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506002) describe a tug-of-war mechanism regulating dynein and kinesin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer cells, identifying a crucial regulatory axis for tumor metastasis.
AB - The membrane-tethered membrane type 1-matrix metalloproteinase (MT1-MMP) mediates proteolysis-based invasive tumor growth. In this issue, Marchesin et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506002) describe a tug-of-war mechanism regulating dynein and kinesin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer cells, identifying a crucial regulatory axis for tumor metastasis.
U2 - 10.1083/jcb.201510009
DO - 10.1083/jcb.201510009
M3 - SCORING: Journal article
C2 - 26504163
VL - 211
SP - 215
EP - 217
JO - J CELL BIOL
JF - J CELL BIOL
SN - 0021-9525
IS - 2
ER -