MT1-MMP: Endosomal delivery drives breast cancer metastasis

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MT1-MMP: Endosomal delivery drives breast cancer metastasis. / Linder, Stefan.

In: J CELL BIOL, Vol. 211, No. 2, 26.10.2015, p. 215-7.

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@article{bc8c4a2a910e48faa9d665957ae2cbe5,
title = "MT1-MMP: Endosomal delivery drives breast cancer metastasis",
abstract = "The membrane-tethered membrane type 1-matrix metalloproteinase (MT1-MMP) mediates proteolysis-based invasive tumor growth. In this issue, Marchesin et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506002) describe a tug-of-war mechanism regulating dynein and kinesin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer cells, identifying a crucial regulatory axis for tumor metastasis.",
author = "Stefan Linder",
note = "{\textcopyright} 2015 Linder.",
year = "2015",
month = oct,
day = "26",
doi = "10.1083/jcb.201510009",
language = "English",
volume = "211",
pages = "215--7",
journal = "J CELL BIOL",
issn = "0021-9525",
publisher = "Rockefeller University Press",
number = "2",

}

RIS

TY - JOUR

T1 - MT1-MMP: Endosomal delivery drives breast cancer metastasis

AU - Linder, Stefan

N1 - © 2015 Linder.

PY - 2015/10/26

Y1 - 2015/10/26

N2 - The membrane-tethered membrane type 1-matrix metalloproteinase (MT1-MMP) mediates proteolysis-based invasive tumor growth. In this issue, Marchesin et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506002) describe a tug-of-war mechanism regulating dynein and kinesin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer cells, identifying a crucial regulatory axis for tumor metastasis.

AB - The membrane-tethered membrane type 1-matrix metalloproteinase (MT1-MMP) mediates proteolysis-based invasive tumor growth. In this issue, Marchesin et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506002) describe a tug-of-war mechanism regulating dynein and kinesin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer cells, identifying a crucial regulatory axis for tumor metastasis.

U2 - 10.1083/jcb.201510009

DO - 10.1083/jcb.201510009

M3 - SCORING: Journal article

C2 - 26504163

VL - 211

SP - 215

EP - 217

JO - J CELL BIOL

JF - J CELL BIOL

SN - 0021-9525

IS - 2

ER -