mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer
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mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer. / Kotzsch, Matthias; Dorn, Julia; Doetzer, Kristina; Schmalfeldt, Barbara; Krol, Janna; Baretton, Gustavo; Kiechle, Marion; Schmitt, Manfred; Magdolen, Viktor.
In: BIOL CHEM, Vol. 392, No. 11, 11.2011, p. 1047-51.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer
AU - Kotzsch, Matthias
AU - Dorn, Julia
AU - Doetzer, Kristina
AU - Schmalfeldt, Barbara
AU - Krol, Janna
AU - Baretton, Gustavo
AU - Kiechle, Marion
AU - Schmitt, Manfred
AU - Magdolen, Viktor
PY - 2011/11
Y1 - 2011/11
N2 - High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified the respective mRNA levels in primary tumor tissue of advanced ovarian cancer patients (n=103) and evaluated their association with clinicopathological parameters and patients' prognosis. mRNA expression levels of all three markers did not show any significant association with overall or progression-free survival, demonstrating that these factors have no prognostic value in advanced ovarian cancer.
AB - High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified the respective mRNA levels in primary tumor tissue of advanced ovarian cancer patients (n=103) and evaluated their association with clinicopathological parameters and patients' prognosis. mRNA expression levels of all three markers did not show any significant association with overall or progression-free survival, demonstrating that these factors have no prognostic value in advanced ovarian cancer.
KW - Female
KW - Gene Expression Regulation, Neoplastic
KW - Humans
KW - Mutation
KW - Ovarian Neoplasms
KW - Ovary
KW - Prognosis
KW - RNA, Messenger
KW - Receptors, Urokinase Plasminogen Activator
KW - rab GTP-Binding Proteins
U2 - 10.1515/BC.2011.166
DO - 10.1515/BC.2011.166
M3 - SCORING: Journal article
C2 - 21848504
VL - 392
SP - 1047
EP - 1051
JO - BIOL CHEM
JF - BIOL CHEM
SN - 1431-6730
IS - 11
ER -