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mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer

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mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer. / Kotzsch, Matthias; Dorn, Julia; Doetzer, Kristina; Schmalfeldt, Barbara; Krol, Janna; Baretton, Gustavo; Kiechle, Marion; Schmitt, Manfred; Magdolen, Viktor.

in: BIOL CHEM, Jahrgang 392, Nr. 11, 11.2011, S. 1047-51.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kotzsch, M, Dorn, J, Doetzer, K, Schmalfeldt, B, Krol, J, Baretton, G, Kiechle, M, Schmitt, M & Magdolen, V 2011, 'mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer', BIOL CHEM, Jg. 392, Nr. 11, S. 1047-51. https://doi.org/10.1515/BC.2011.166

APA

Kotzsch, M., Dorn, J., Doetzer, K., Schmalfeldt, B., Krol, J., Baretton, G., Kiechle, M., Schmitt, M., & Magdolen, V. (2011). mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer. BIOL CHEM, 392(11), 1047-51. https://doi.org/10.1515/BC.2011.166

Vancouver

Kotzsch M, Dorn J, Doetzer K, Schmalfeldt B, Krol J, Baretton G et al. mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer. BIOL CHEM. 2011 Nov;392(11):1047-51. https://doi.org/10.1515/BC.2011.166

Bibtex

@article{ac32da34590345bb8fd099e26786b28f,
title = "mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer",
abstract = "High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified the respective mRNA levels in primary tumor tissue of advanced ovarian cancer patients (n=103) and evaluated their association with clinicopathological parameters and patients' prognosis. mRNA expression levels of all three markers did not show any significant association with overall or progression-free survival, demonstrating that these factors have no prognostic value in advanced ovarian cancer.",
keywords = "Female, Gene Expression Regulation, Neoplastic, Humans, Mutation, Ovarian Neoplasms, Ovary, Prognosis, RNA, Messenger, Receptors, Urokinase Plasminogen Activator, rab GTP-Binding Proteins",
author = "Matthias Kotzsch and Julia Dorn and Kristina Doetzer and Barbara Schmalfeldt and Janna Krol and Gustavo Baretton and Marion Kiechle and Manfred Schmitt and Viktor Magdolen",
year = "2011",
month = nov,
doi = "10.1515/BC.2011.166",
language = "English",
volume = "392",
pages = "1047--51",
journal = "BIOL CHEM",
issn = "1431-6730",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "11",

}

RIS

TY - JOUR

T1 - mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer

AU - Kotzsch, Matthias

AU - Dorn, Julia

AU - Doetzer, Kristina

AU - Schmalfeldt, Barbara

AU - Krol, Janna

AU - Baretton, Gustavo

AU - Kiechle, Marion

AU - Schmitt, Manfred

AU - Magdolen, Viktor

PY - 2011/11

Y1 - 2011/11

N2 - High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified the respective mRNA levels in primary tumor tissue of advanced ovarian cancer patients (n=103) and evaluated their association with clinicopathological parameters and patients' prognosis. mRNA expression levels of all three markers did not show any significant association with overall or progression-free survival, demonstrating that these factors have no prognostic value in advanced ovarian cancer.

AB - High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified the respective mRNA levels in primary tumor tissue of advanced ovarian cancer patients (n=103) and evaluated their association with clinicopathological parameters and patients' prognosis. mRNA expression levels of all three markers did not show any significant association with overall or progression-free survival, demonstrating that these factors have no prognostic value in advanced ovarian cancer.

KW - Female

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Mutation

KW - Ovarian Neoplasms

KW - Ovary

KW - Prognosis

KW - RNA, Messenger

KW - Receptors, Urokinase Plasminogen Activator

KW - rab GTP-Binding Proteins

U2 - 10.1515/BC.2011.166

DO - 10.1515/BC.2011.166

M3 - SCORING: Journal article

C2 - 21848504

VL - 392

SP - 1047

EP - 1051

JO - BIOL CHEM

JF - BIOL CHEM

SN - 1431-6730

IS - 11

ER -