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MRI-based quantitative susceptibility mapping (QSM) and R2* mapping of liver iron overload Comparison with SQUID-based biomagnetic liver susceptometry

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MRI-based quantitative susceptibility mapping (QSM) and R2* mapping of liver iron overload Comparison with SQUID-based biomagnetic liver susceptometry. / Sharma, Samir D; Fischer, Roland; Schoennagel, Bjoern P; Nielsen, Peter; Kooijman, Hendrik; Yamamura, Jin; Adam, Gerhard; Bannas, Peter; Hernando, Diego; Reeder, Scott B.

In: MAGN RESON MED, Vol. 78, No. 1, 07.2017, p. 264-270.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sharma, SD, Fischer, R, Schoennagel, BP, Nielsen, P, Kooijman, H, Yamamura, J, Adam, G, Bannas, P, Hernando, D & Reeder, SB 2017, 'MRI-based quantitative susceptibility mapping (QSM) and R2* mapping of liver iron overload Comparison with SQUID-based biomagnetic liver susceptometry', MAGN RESON MED, vol. 78, no. 1, pp. 264-270. https://doi.org/10.1002/mrm.26358

APA

Sharma, S. D., Fischer, R., Schoennagel, B. P., Nielsen, P., Kooijman, H., Yamamura, J., Adam, G., Bannas, P., Hernando, D., & Reeder, S. B. (2017). MRI-based quantitative susceptibility mapping (QSM) and R2* mapping of liver iron overload Comparison with SQUID-based biomagnetic liver susceptometry. MAGN RESON MED, 78(1), 264-270. https://doi.org/10.1002/mrm.26358

Vancouver

Sharma SD, Fischer R, Schoennagel BP, Nielsen P, Kooijman H, Yamamura J et al. MRI-based quantitative susceptibility mapping (QSM) and R2* mapping of liver iron overload Comparison with SQUID-based biomagnetic liver susceptometry. MAGN RESON MED. 2017 Jul;78(1):264-270. https://doi.org/10.1002/mrm.26358

Bibtex

@article{dc92b91b3d4d428ca34c881c53b8f65b,
title = "MRI-based quantitative susceptibility mapping (QSM) and R2* mapping of liver iron overload Comparison with SQUID-based biomagnetic liver susceptometry",
abstract = "PURPOSE: We aimed to determine the agreement between quantitative susceptibility mapping (QSM)-based biomagnetic liver susceptometry (BLS) and confounder-corrected R2* mapping with superconducting quantum interference device (SQUID)-based biomagnetic liver susceptometry in patients with liver iron overload.METHODS: Data were acquired from two healthy controls and 22 patients undergoing MRI and SQUID-BLS as part of routine monitoring for iron overload. Magnetic resonance imaging was performed on a 3T system using a three-dimensional multi-echo gradient-echo acquisition. Both magnetic susceptibility and R2* of the liver were estimated from this acquisition. Linear regression was used to compare estimates of QSM-BLS and R2* to SQUID-BLS.RESULTS: Both QSM-BLS and confounder-corrected R2* were sensitive to the presence of iron in the liver. Linear regression between QSM-BLS and SQUID-BLS demonstrated the following relationship: QSM-BLS = (-0.22 ± 0.11) + (0.49 ± 0.05) · SQUID-BLS with r(2)  = 0.88. The coefficient of determination between liver R2* and SQUID-BLS was also r(2)  = 0.88.CONCLUSION: We determined a strong correlation between both QSM-BLS and confounder-corrected R2* to SQUID-BLS. This study demonstrates the feasibility of QSM-BLS and confounder-corrected R2* for assessing liver iron overload, particularly when SQUID systems are not accessible. Magn Reson Med, 2016. {\textcopyright} 2016 International Society for Magnetic Resonance in Medicine.",
author = "Sharma, {Samir D} and Roland Fischer and Schoennagel, {Bjoern P} and Peter Nielsen and Hendrik Kooijman and Jin Yamamura and Gerhard Adam and Peter Bannas and Diego Hernando and Reeder, {Scott B}",
note = "{\textcopyright} 2016 International Society for Magnetic Resonance in Medicine.",
year = "2017",
month = jul,
doi = "10.1002/mrm.26358",
language = "English",
volume = "78",
pages = "264--270",
journal = "MAGN RESON MED",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - MRI-based quantitative susceptibility mapping (QSM) and R2* mapping of liver iron overload Comparison with SQUID-based biomagnetic liver susceptometry

AU - Sharma, Samir D

AU - Fischer, Roland

AU - Schoennagel, Bjoern P

AU - Nielsen, Peter

AU - Kooijman, Hendrik

AU - Yamamura, Jin

AU - Adam, Gerhard

AU - Bannas, Peter

AU - Hernando, Diego

AU - Reeder, Scott B

N1 - © 2016 International Society for Magnetic Resonance in Medicine.

PY - 2017/7

Y1 - 2017/7

N2 - PURPOSE: We aimed to determine the agreement between quantitative susceptibility mapping (QSM)-based biomagnetic liver susceptometry (BLS) and confounder-corrected R2* mapping with superconducting quantum interference device (SQUID)-based biomagnetic liver susceptometry in patients with liver iron overload.METHODS: Data were acquired from two healthy controls and 22 patients undergoing MRI and SQUID-BLS as part of routine monitoring for iron overload. Magnetic resonance imaging was performed on a 3T system using a three-dimensional multi-echo gradient-echo acquisition. Both magnetic susceptibility and R2* of the liver were estimated from this acquisition. Linear regression was used to compare estimates of QSM-BLS and R2* to SQUID-BLS.RESULTS: Both QSM-BLS and confounder-corrected R2* were sensitive to the presence of iron in the liver. Linear regression between QSM-BLS and SQUID-BLS demonstrated the following relationship: QSM-BLS = (-0.22 ± 0.11) + (0.49 ± 0.05) · SQUID-BLS with r(2)  = 0.88. The coefficient of determination between liver R2* and SQUID-BLS was also r(2)  = 0.88.CONCLUSION: We determined a strong correlation between both QSM-BLS and confounder-corrected R2* to SQUID-BLS. This study demonstrates the feasibility of QSM-BLS and confounder-corrected R2* for assessing liver iron overload, particularly when SQUID systems are not accessible. Magn Reson Med, 2016. © 2016 International Society for Magnetic Resonance in Medicine.

AB - PURPOSE: We aimed to determine the agreement between quantitative susceptibility mapping (QSM)-based biomagnetic liver susceptometry (BLS) and confounder-corrected R2* mapping with superconducting quantum interference device (SQUID)-based biomagnetic liver susceptometry in patients with liver iron overload.METHODS: Data were acquired from two healthy controls and 22 patients undergoing MRI and SQUID-BLS as part of routine monitoring for iron overload. Magnetic resonance imaging was performed on a 3T system using a three-dimensional multi-echo gradient-echo acquisition. Both magnetic susceptibility and R2* of the liver were estimated from this acquisition. Linear regression was used to compare estimates of QSM-BLS and R2* to SQUID-BLS.RESULTS: Both QSM-BLS and confounder-corrected R2* were sensitive to the presence of iron in the liver. Linear regression between QSM-BLS and SQUID-BLS demonstrated the following relationship: QSM-BLS = (-0.22 ± 0.11) + (0.49 ± 0.05) · SQUID-BLS with r(2)  = 0.88. The coefficient of determination between liver R2* and SQUID-BLS was also r(2)  = 0.88.CONCLUSION: We determined a strong correlation between both QSM-BLS and confounder-corrected R2* to SQUID-BLS. This study demonstrates the feasibility of QSM-BLS and confounder-corrected R2* for assessing liver iron overload, particularly when SQUID systems are not accessible. Magn Reson Med, 2016. © 2016 International Society for Magnetic Resonance in Medicine.

U2 - 10.1002/mrm.26358

DO - 10.1002/mrm.26358

M3 - SCORING: Journal article

C2 - 27509836

VL - 78

SP - 264

EP - 270

JO - MAGN RESON MED

JF - MAGN RESON MED

SN - 0740-3194

IS - 1

ER -