MRI-based quantitative susceptibility mapping (QSM) and R2* mapping of liver iron overload Comparison with SQUID-based biomagnetic liver susceptometry
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Abstract
PURPOSE: We aimed to determine the agreement between quantitative susceptibility mapping (QSM)-based biomagnetic liver susceptometry (BLS) and confounder-corrected R2* mapping with superconducting quantum interference device (SQUID)-based biomagnetic liver susceptometry in patients with liver iron overload.
METHODS: Data were acquired from two healthy controls and 22 patients undergoing MRI and SQUID-BLS as part of routine monitoring for iron overload. Magnetic resonance imaging was performed on a 3T system using a three-dimensional multi-echo gradient-echo acquisition. Both magnetic susceptibility and R2* of the liver were estimated from this acquisition. Linear regression was used to compare estimates of QSM-BLS and R2* to SQUID-BLS.
RESULTS: Both QSM-BLS and confounder-corrected R2* were sensitive to the presence of iron in the liver. Linear regression between QSM-BLS and SQUID-BLS demonstrated the following relationship: QSM-BLS = (-0.22 ± 0.11) + (0.49 ± 0.05) · SQUID-BLS with r(2) = 0.88. The coefficient of determination between liver R2* and SQUID-BLS was also r(2) = 0.88.
CONCLUSION: We determined a strong correlation between both QSM-BLS and confounder-corrected R2* to SQUID-BLS. This study demonstrates the feasibility of QSM-BLS and confounder-corrected R2* for assessing liver iron overload, particularly when SQUID systems are not accessible. Magn Reson Med, 2016. © 2016 International Society for Magnetic Resonance in Medicine.
Bibliographical data
Original language | English |
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ISSN | 0740-3194 |
DOIs | |
Publication status | Published - 07.2017 |
PubMed | 27509836 |
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