Mosaic theory revised: inflammation and salt play central roles in arterial hypertension

Felicitas E Hengel; Jean-Pierre Benitah; Ulrich O Wenzel

doi:10.1038/s41423-022-00851-8

Mosaic theory revised: inflammation and salt play central roles in arterial hypertension

Standard

Mosaic theory revised: inflammation and salt play central roles in arterial hypertension. / Hengel, Felicitas E; Benitah, Jean-Pierre; Wenzel, Ulrich O.

In: CELL MOL IMMUNOL, Vol. 19, No. 5, 05.2022, p. 561-576.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Hengel, FE, Benitah, J-P & Wenzel, UO 2022, 'Mosaic theory revised: inflammation and salt play central roles in arterial hypertension', CELL MOL IMMUNOL, vol. 19, no. 5, pp. 561-576. https://doi.org/10.1038/s41423-022-00851-8

APA

Hengel, F. E., Benitah, J-P., & Wenzel, U. O. (2022). Mosaic theory revised: inflammation and salt play central roles in arterial hypertension. CELL MOL IMMUNOL, 19(5), 561-576. https://doi.org/10.1038/s41423-022-00851-8

Vancouver

Hengel FE, Benitah J-P, Wenzel UO. Mosaic theory revised: inflammation and salt play central roles in arterial hypertension. CELL MOL IMMUNOL. 2022 May;19(5):561-576. https://doi.org/10.1038/s41423-022-00851-8

Bibtex

@article{6c59f6013c184a5d8a06831d5fefaa2a,

title = "Mosaic theory revised: inflammation and salt play central roles in arterial hypertension",

abstract = "The mosaic theory of hypertension was advocated by Irvine Page ~80 years ago and suggested that hypertension resulted from the close interactions of different causes. Increasing evidence indicates that hypertension and hypertensive end-organ damage are not only mediated by the proposed mechanisms that result in hemodynamic injury. Inflammation plays an important role in the pathophysiology and contributes to the deleterious consequences of arterial hypertension. Sodium intake is indispensable for normal body function but can be detrimental when it exceeds dietary requirements. Recent data show that sodium levels also modulate the function of monocytes/macrophages, dendritic cells, and different T-cell subsets. Some of these effects are mediated by changes in the microbiome and metabolome due to high-salt intake. The purpose of this review is to propose a revised and extended version of the mosaic theory by summarizing and integrating recent advances in salt, immunity, and hypertension research. Salt and inflammation are placed in the middle of the mosaic because both factors influence each of the remaining pieces.",

keywords = "Aldosterone, Humans, Hypertension, Inflammation/complications, Sodium Chloride, Dietary/adverse effects",

author = "Hengel, {Felicitas E} and Jean-Pierre Benitah and Wenzel, {Ulrich O}",

note = "{\textcopyright} 2022. The Author(s).",

year = "2022",

month = may,

doi = "10.1038/s41423-022-00851-8",

language = "English",

volume = "19",

pages = "561--576",

journal = "CELL MOL IMMUNOL",

issn = "1672-7681",

publisher = "NATURE PUBLISHING GROUP",

number = "5",

}

RIS

TY - JOUR

T1 - Mosaic theory revised: inflammation and salt play central roles in arterial hypertension

AU - Hengel, Felicitas E

AU - Benitah, Jean-Pierre

AU - Wenzel, Ulrich O

PY - 2022/5

Y1 - 2022/5

N2 - The mosaic theory of hypertension was advocated by Irvine Page ~80 years ago and suggested that hypertension resulted from the close interactions of different causes. Increasing evidence indicates that hypertension and hypertensive end-organ damage are not only mediated by the proposed mechanisms that result in hemodynamic injury. Inflammation plays an important role in the pathophysiology and contributes to the deleterious consequences of arterial hypertension. Sodium intake is indispensable for normal body function but can be detrimental when it exceeds dietary requirements. Recent data show that sodium levels also modulate the function of monocytes/macrophages, dendritic cells, and different T-cell subsets. Some of these effects are mediated by changes in the microbiome and metabolome due to high-salt intake. The purpose of this review is to propose a revised and extended version of the mosaic theory by summarizing and integrating recent advances in salt, immunity, and hypertension research. Salt and inflammation are placed in the middle of the mosaic because both factors influence each of the remaining pieces.

AB - The mosaic theory of hypertension was advocated by Irvine Page ~80 years ago and suggested that hypertension resulted from the close interactions of different causes. Increasing evidence indicates that hypertension and hypertensive end-organ damage are not only mediated by the proposed mechanisms that result in hemodynamic injury. Inflammation plays an important role in the pathophysiology and contributes to the deleterious consequences of arterial hypertension. Sodium intake is indispensable for normal body function but can be detrimental when it exceeds dietary requirements. Recent data show that sodium levels also modulate the function of monocytes/macrophages, dendritic cells, and different T-cell subsets. Some of these effects are mediated by changes in the microbiome and metabolome due to high-salt intake. The purpose of this review is to propose a revised and extended version of the mosaic theory by summarizing and integrating recent advances in salt, immunity, and hypertension research. Salt and inflammation are placed in the middle of the mosaic because both factors influence each of the remaining pieces.

KW - Aldosterone

KW - Humans

KW - Hypertension

KW - Inflammation/complications

KW - Sodium Chloride, Dietary/adverse effects

U2 - 10.1038/s41423-022-00851-8

DO - 10.1038/s41423-022-00851-8

M3 - SCORING: Review article

C2 - 35354938

VL - 19

SP - 561

EP - 576

JO - CELL MOL IMMUNOL

JF - CELL MOL IMMUNOL

SN - 1672-7681

IS - 5

ER -