Mosaic theory revised: inflammation and salt play central roles in arterial hypertension
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Mosaic theory revised: inflammation and salt play central roles in arterial hypertension. / Hengel, Felicitas E; Benitah, Jean-Pierre; Wenzel, Ulrich O.
in: CELL MOL IMMUNOL, Jahrgang 19, Nr. 5, 05.2022, S. 561-576.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Mosaic theory revised: inflammation and salt play central roles in arterial hypertension
AU - Hengel, Felicitas E
AU - Benitah, Jean-Pierre
AU - Wenzel, Ulrich O
N1 - © 2022. The Author(s).
PY - 2022/5
Y1 - 2022/5
N2 - The mosaic theory of hypertension was advocated by Irvine Page ~80 years ago and suggested that hypertension resulted from the close interactions of different causes. Increasing evidence indicates that hypertension and hypertensive end-organ damage are not only mediated by the proposed mechanisms that result in hemodynamic injury. Inflammation plays an important role in the pathophysiology and contributes to the deleterious consequences of arterial hypertension. Sodium intake is indispensable for normal body function but can be detrimental when it exceeds dietary requirements. Recent data show that sodium levels also modulate the function of monocytes/macrophages, dendritic cells, and different T-cell subsets. Some of these effects are mediated by changes in the microbiome and metabolome due to high-salt intake. The purpose of this review is to propose a revised and extended version of the mosaic theory by summarizing and integrating recent advances in salt, immunity, and hypertension research. Salt and inflammation are placed in the middle of the mosaic because both factors influence each of the remaining pieces.
AB - The mosaic theory of hypertension was advocated by Irvine Page ~80 years ago and suggested that hypertension resulted from the close interactions of different causes. Increasing evidence indicates that hypertension and hypertensive end-organ damage are not only mediated by the proposed mechanisms that result in hemodynamic injury. Inflammation plays an important role in the pathophysiology and contributes to the deleterious consequences of arterial hypertension. Sodium intake is indispensable for normal body function but can be detrimental when it exceeds dietary requirements. Recent data show that sodium levels also modulate the function of monocytes/macrophages, dendritic cells, and different T-cell subsets. Some of these effects are mediated by changes in the microbiome and metabolome due to high-salt intake. The purpose of this review is to propose a revised and extended version of the mosaic theory by summarizing and integrating recent advances in salt, immunity, and hypertension research. Salt and inflammation are placed in the middle of the mosaic because both factors influence each of the remaining pieces.
KW - Aldosterone
KW - Humans
KW - Hypertension
KW - Inflammation/complications
KW - Sodium Chloride, Dietary/adverse effects
U2 - 10.1038/s41423-022-00851-8
DO - 10.1038/s41423-022-00851-8
M3 - SCORING: Review article
C2 - 35354938
VL - 19
SP - 561
EP - 576
JO - CELL MOL IMMUNOL
JF - CELL MOL IMMUNOL
SN - 1672-7681
IS - 5
ER -