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Monocyte preseeding leads to an increased implant bed vascularization of biphasic calcium phosphate bone substitutes via vessel maturation

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Monocyte preseeding leads to an increased implant bed vascularization of biphasic calcium phosphate bone substitutes via vessel maturation. / Barbeck, M; Unger, R E; Booms, P; Dohle, E; Sader, R A; Kirkpatrick, C J; Ghanaati, S.

In: J BIOMED MATER RES A, Vol. 104, No. 12, 12.2016, p. 2928-2935.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Barbeck, M, Unger, RE, Booms, P, Dohle, E, Sader, RA, Kirkpatrick, CJ & Ghanaati, S 2016, 'Monocyte preseeding leads to an increased implant bed vascularization of biphasic calcium phosphate bone substitutes via vessel maturation', J BIOMED MATER RES A, vol. 104, no. 12, pp. 2928-2935. https://doi.org/10.1002/jbm.a.35834

APA

Barbeck, M., Unger, R. E., Booms, P., Dohle, E., Sader, R. A., Kirkpatrick, C. J., & Ghanaati, S. (2016). Monocyte preseeding leads to an increased implant bed vascularization of biphasic calcium phosphate bone substitutes via vessel maturation. J BIOMED MATER RES A, 104(12), 2928-2935. https://doi.org/10.1002/jbm.a.35834

Vancouver

Barbeck M, Unger RE, Booms P, Dohle E, Sader RA, Kirkpatrick CJ et al. Monocyte preseeding leads to an increased implant bed vascularization of biphasic calcium phosphate bone substitutes via vessel maturation. J BIOMED MATER RES A. 2016 Dec;104(12):2928-2935. https://doi.org/10.1002/jbm.a.35834

Bibtex

@article{27c17cf4a0b740469177d7c443bd45b0,
title = "Monocyte preseeding leads to an increased implant bed vascularization of biphasic calcium phosphate bone substitutes via vessel maturation",
abstract = "The present study analyzes the influence of the addition of monocytes to a biphasic bone substitute with two granule sizes (400-700 μm and 500-1000 μm). The majority of the added monocytes was detectable as mononuclear cells, while also low amounts of (chimeric) multinucleated giant cells (MNGCs) were found. No increase in the total number of MNGCs was established, but a significantly increased percent vascularization. Altogether, the results show that the added monocytes become involved in the tissue response to a biomaterial without marked changes in the overall reaction. Monocyte addition enables an increased implant bed vascularization especially via induction of vessel maturation and, thus intervenes positively in the healing reaction to a biomaterial. {\textcopyright} 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2928-2935, 2016.",
keywords = "Animals, Bone Substitutes, Cells, Cultured, Female, Giant Cells, Humans, Hydroxyapatites, Materials Testing, Mice, SCID, Monocytes, Neovascularization, Physiologic, Prostheses and Implants, Journal Article, Research Support, Non-U.S. Gov't",
author = "M Barbeck and Unger, {R E} and P Booms and E Dohle and Sader, {R A} and Kirkpatrick, {C J} and S Ghanaati",
note = "{\textcopyright} 2016 Wiley Periodicals, Inc.",
year = "2016",
month = dec,
doi = "10.1002/jbm.a.35834",
language = "English",
volume = "104",
pages = "2928--2935",
journal = "J BIOMED MATER RES A",
issn = "1549-3296",
publisher = "John Wiley and Sons Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - Monocyte preseeding leads to an increased implant bed vascularization of biphasic calcium phosphate bone substitutes via vessel maturation

AU - Barbeck, M

AU - Unger, R E

AU - Booms, P

AU - Dohle, E

AU - Sader, R A

AU - Kirkpatrick, C J

AU - Ghanaati, S

N1 - © 2016 Wiley Periodicals, Inc.

PY - 2016/12

Y1 - 2016/12

N2 - The present study analyzes the influence of the addition of monocytes to a biphasic bone substitute with two granule sizes (400-700 μm and 500-1000 μm). The majority of the added monocytes was detectable as mononuclear cells, while also low amounts of (chimeric) multinucleated giant cells (MNGCs) were found. No increase in the total number of MNGCs was established, but a significantly increased percent vascularization. Altogether, the results show that the added monocytes become involved in the tissue response to a biomaterial without marked changes in the overall reaction. Monocyte addition enables an increased implant bed vascularization especially via induction of vessel maturation and, thus intervenes positively in the healing reaction to a biomaterial. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2928-2935, 2016.

AB - The present study analyzes the influence of the addition of monocytes to a biphasic bone substitute with two granule sizes (400-700 μm and 500-1000 μm). The majority of the added monocytes was detectable as mononuclear cells, while also low amounts of (chimeric) multinucleated giant cells (MNGCs) were found. No increase in the total number of MNGCs was established, but a significantly increased percent vascularization. Altogether, the results show that the added monocytes become involved in the tissue response to a biomaterial without marked changes in the overall reaction. Monocyte addition enables an increased implant bed vascularization especially via induction of vessel maturation and, thus intervenes positively in the healing reaction to a biomaterial. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2928-2935, 2016.

KW - Animals

KW - Bone Substitutes

KW - Cells, Cultured

KW - Female

KW - Giant Cells

KW - Humans

KW - Hydroxyapatites

KW - Materials Testing

KW - Mice, SCID

KW - Monocytes

KW - Neovascularization, Physiologic

KW - Prostheses and Implants

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/jbm.a.35834

DO - 10.1002/jbm.a.35834

M3 - SCORING: Journal article

C2 - 27419378

VL - 104

SP - 2928

EP - 2935

JO - J BIOMED MATER RES A

JF - J BIOMED MATER RES A

SN - 1549-3296

IS - 12

ER -