Monocyte preseeding leads to an increased implant bed vascularization of biphasic calcium phosphate bone substitutes via vessel maturation
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Monocyte preseeding leads to an increased implant bed vascularization of biphasic calcium phosphate bone substitutes via vessel maturation. / Barbeck, M; Unger, R E; Booms, P; Dohle, E; Sader, R A; Kirkpatrick, C J; Ghanaati, S.
in: J BIOMED MATER RES A, Jahrgang 104, Nr. 12, 12.2016, S. 2928-2935.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Monocyte preseeding leads to an increased implant bed vascularization of biphasic calcium phosphate bone substitutes via vessel maturation
AU - Barbeck, M
AU - Unger, R E
AU - Booms, P
AU - Dohle, E
AU - Sader, R A
AU - Kirkpatrick, C J
AU - Ghanaati, S
N1 - © 2016 Wiley Periodicals, Inc.
PY - 2016/12
Y1 - 2016/12
N2 - The present study analyzes the influence of the addition of monocytes to a biphasic bone substitute with two granule sizes (400-700 μm and 500-1000 μm). The majority of the added monocytes was detectable as mononuclear cells, while also low amounts of (chimeric) multinucleated giant cells (MNGCs) were found. No increase in the total number of MNGCs was established, but a significantly increased percent vascularization. Altogether, the results show that the added monocytes become involved in the tissue response to a biomaterial without marked changes in the overall reaction. Monocyte addition enables an increased implant bed vascularization especially via induction of vessel maturation and, thus intervenes positively in the healing reaction to a biomaterial. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2928-2935, 2016.
AB - The present study analyzes the influence of the addition of monocytes to a biphasic bone substitute with two granule sizes (400-700 μm and 500-1000 μm). The majority of the added monocytes was detectable as mononuclear cells, while also low amounts of (chimeric) multinucleated giant cells (MNGCs) were found. No increase in the total number of MNGCs was established, but a significantly increased percent vascularization. Altogether, the results show that the added monocytes become involved in the tissue response to a biomaterial without marked changes in the overall reaction. Monocyte addition enables an increased implant bed vascularization especially via induction of vessel maturation and, thus intervenes positively in the healing reaction to a biomaterial. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2928-2935, 2016.
KW - Animals
KW - Bone Substitutes
KW - Cells, Cultured
KW - Female
KW - Giant Cells
KW - Humans
KW - Hydroxyapatites
KW - Materials Testing
KW - Mice, SCID
KW - Monocytes
KW - Neovascularization, Physiologic
KW - Prostheses and Implants
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1002/jbm.a.35834
DO - 10.1002/jbm.a.35834
M3 - SCORING: Journal article
C2 - 27419378
VL - 104
SP - 2928
EP - 2935
JO - J BIOMED MATER RES A
JF - J BIOMED MATER RES A
SN - 1549-3296
IS - 12
ER -