Research ExplorerPublicationsMonitoring of hepatitis E virus in wastewater can identify c...

Monitoring of hepatitis E virus in wastewater can identify clinically relevant variants

Standard

Monitoring of hepatitis E virus in wastewater can identify clinically relevant variants. / Rau, Fiona; Elsner, Carina; Meister, Toni; Gömer, André ; Kallies, René; Dittmer, Ulf; Steinmann, Eike; Todt, Daniel.

In: LIVER INT, Vol. 44, No. 3, 03.2024, p. 637-643.

Research output: SCORING: Contribution to journal › Short publication › Research › peer-review

Harvard

Rau, F, Elsner, C, Meister, T, Gömer, A, Kallies, R, Dittmer, U, Steinmann, E & Todt, D 2024, 'Monitoring of hepatitis E virus in wastewater can identify clinically relevant variants', LIVER INT, vol. 44, no. 3, pp. 637-643. https://doi.org/10.1111/liv.15842

APA

Rau, F., Elsner, C., Meister, T., Gömer, A., Kallies, R., Dittmer, U., Steinmann, E., & Todt, D. (2024). Monitoring of hepatitis E virus in wastewater can identify clinically relevant variants. LIVER INT, 44(3), 637-643. https://doi.org/10.1111/liv.15842

Vancouver

Rau F, Elsner C, Meister T, Gömer A, Kallies R, Dittmer U et al. Monitoring of hepatitis E virus in wastewater can identify clinically relevant variants. LIVER INT. 2024 Mar;44(3):637-643. https://doi.org/10.1111/liv.15842

Bibtex

@article{5f006b700924496ab999d1cc2c540584,
title = "Monitoring of hepatitis E virus in wastewater can identify clinically relevant variants",
abstract = "Hepatitis E virus (HEV) is prevalent worldwide and can cause persistent infection with severe morbidity. Antiviral treatment approaches can lead to the emergence of viral variants encoding escape mutations that may impede viral clearance. The frequency of these variants remains unknown in the human population as well as environment due to limited comprehensive data on HEV diversity. In this study, we investigated the HEV prevalence and diversity of circulating variants in environmental samples, that is, wastewater and rivers from North-Rhine Westphalia, Germany. HEV prevalence could be determined with 73% of samples tested positive for viral RNA via qRT-PCR. Using high-throughput sequencing, we were able to assess the overall genetic diversity in these samples and identified the presence of clinically relevant variants associated with drug resistance. In summary, monitoring variants from environmental samples could provide valuable insights into estimating HEV prevalence and identifying circulating variants that can impact treatment outcome.",
author = "Fiona Rau and Carina Elsner and Toni Meister and Andr{\'e} G{\"o}mer and Ren{\'e} Kallies and Ulf Dittmer and Eike Steinmann and Daniel Todt",
note = "Brief Report",
year = "2024",
month = mar,
doi = "10.1111/liv.15842",
language = "English",
volume = "44",
pages = "637--643",
journal = "LIVER INT",
issn = "1478-3223",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Monitoring of hepatitis E virus in wastewater can identify clinically relevant variants

AU - Rau, Fiona

AU - Elsner, Carina

AU - Meister, Toni

AU - Gömer, André

AU - Kallies, René

AU - Dittmer, Ulf

AU - Steinmann, Eike

AU - Todt, Daniel

N1 - Brief Report

PY - 2024/3

Y1 - 2024/3

N2 - Hepatitis E virus (HEV) is prevalent worldwide and can cause persistent infection with severe morbidity. Antiviral treatment approaches can lead to the emergence of viral variants encoding escape mutations that may impede viral clearance. The frequency of these variants remains unknown in the human population as well as environment due to limited comprehensive data on HEV diversity. In this study, we investigated the HEV prevalence and diversity of circulating variants in environmental samples, that is, wastewater and rivers from North-Rhine Westphalia, Germany. HEV prevalence could be determined with 73% of samples tested positive for viral RNA via qRT-PCR. Using high-throughput sequencing, we were able to assess the overall genetic diversity in these samples and identified the presence of clinically relevant variants associated with drug resistance. In summary, monitoring variants from environmental samples could provide valuable insights into estimating HEV prevalence and identifying circulating variants that can impact treatment outcome.

AB - Hepatitis E virus (HEV) is prevalent worldwide and can cause persistent infection with severe morbidity. Antiviral treatment approaches can lead to the emergence of viral variants encoding escape mutations that may impede viral clearance. The frequency of these variants remains unknown in the human population as well as environment due to limited comprehensive data on HEV diversity. In this study, we investigated the HEV prevalence and diversity of circulating variants in environmental samples, that is, wastewater and rivers from North-Rhine Westphalia, Germany. HEV prevalence could be determined with 73% of samples tested positive for viral RNA via qRT-PCR. Using high-throughput sequencing, we were able to assess the overall genetic diversity in these samples and identified the presence of clinically relevant variants associated with drug resistance. In summary, monitoring variants from environmental samples could provide valuable insights into estimating HEV prevalence and identifying circulating variants that can impact treatment outcome.

U2 - 10.1111/liv.15842

DO - 10.1111/liv.15842

M3 - Short publication

C2 - 38291853

VL - 44

SP - 637

EP - 643

JO - LIVER INT

JF - LIVER INT

SN - 1478-3223

IS - 3

ER -