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Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes

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Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes : first results from a prospective multicenter German diagnostic study. / Braulke, Friederike; Jung, Klaus; Schanz, Julie; Götze, Katharina; Müller-Thomas, Catharina; Platzbecker, Uwe; Germing, Ulrich; Brümmendorf, Tim H; Bug, Gesine; Ottmann, Oliver; Giagounidis, Aristoteles A N; Stadler, Michael; Hofmann, Wolf-Karsten; Schafhausen, Philippe; Lübbert, Michael; Schlenk, Richard F; Blau, Igor W; Ganster, Christina; Pfeiffer, Sebastian; Shirneshan, Katayoon; Metz, Michael; Detken, Sven; Seraphin, Jörg; Jentsch-Ullrich, Kathleen; Böhme, Angelika; Schmidt, Burkhard; Trümper, Lorenz; Haase, Detlef.

In: Leukemia research, Vol. 37, No. 8, 01.08.2013, p. 900-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Braulke, F, Jung, K, Schanz, J, Götze, K, Müller-Thomas, C, Platzbecker, U, Germing, U, Brümmendorf, TH, Bug, G, Ottmann, O, Giagounidis, AAN, Stadler, M, Hofmann, W-K, Schafhausen, P, Lübbert, M, Schlenk, RF, Blau, IW, Ganster, C, Pfeiffer, S, Shirneshan, K, Metz, M, Detken, S, Seraphin, J, Jentsch-Ullrich, K, Böhme, A, Schmidt, B, Trümper, L & Haase, D 2013, 'Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes: first results from a prospective multicenter German diagnostic study', Leukemia research, vol. 37, no. 8, pp. 900-6. https://doi.org/10.1016/j.leukres.2013.03.019

APA

Braulke, F., Jung, K., Schanz, J., Götze, K., Müller-Thomas, C., Platzbecker, U., Germing, U., Brümmendorf, T. H., Bug, G., Ottmann, O., Giagounidis, A. A. N., Stadler, M., Hofmann, W-K., Schafhausen, P., Lübbert, M., Schlenk, R. F., Blau, I. W., Ganster, C., Pfeiffer, S., ... Haase, D. (2013). Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes: first results from a prospective multicenter German diagnostic study. Leukemia research, 37(8), 900-6. https://doi.org/10.1016/j.leukres.2013.03.019

Vancouver

Braulke F, Jung K, Schanz J, Götze K, Müller-Thomas C, Platzbecker U et al. Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes: first results from a prospective multicenter German diagnostic study. Leukemia research. 2013 Aug 1;37(8):900-6. https://doi.org/10.1016/j.leukres.2013.03.019

Bibtex

@article{75231ead723d4892977bcd6bab7571d9,
title = "Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes: first results from a prospective multicenter German diagnostic study",
abstract = "The gold standard of cytogenetic analysis in myelodysplastic syndromes (MDS) is conventional chromosome banding (CCB) analysis of bone marrow (BM) metaphases. Most aberrations can also be detected by fluorescence-in situ-hybridization (FISH). For this prospective multicenter German diagnostic study (www.clinicaltrials.gov: #NCT01355913) 360 patients, as yet, were followed up to 3 years by sequential FISH analyses of immunomagnetically enriched CD34+ peripheral blood (PB) cells using comprehensive FISH probe panels, resulting in a total number of 19,516 FISH analyses. We demonstrate that CD34+ PB FISH correlates significantly with CCB analysis and represents a feasible method for a reliable non-invasive cytogenetic monitoring from PB.",
keywords = "Adult, Aged, Aged, 80 and over, Antigens, CD34, Antineoplastic Combined Chemotherapy Protocols, Azacitidine, Chromosome Aberrations, Chromosome Banding, Female, Follow-Up Studies, Germany, Humans, In Situ Hybridization, Fluorescence, Male, Middle Aged, Myelodysplastic Syndromes, Prospective Studies, Thalidomide, Time Factors, Treatment Outcome",
author = "Friederike Braulke and Klaus Jung and Julie Schanz and Katharina G{\"o}tze and Catharina M{\"u}ller-Thomas and Uwe Platzbecker and Ulrich Germing and Br{\"u}mmendorf, {Tim H} and Gesine Bug and Oliver Ottmann and Giagounidis, {Aristoteles A N} and Michael Stadler and Wolf-Karsten Hofmann and Philippe Schafhausen and Michael L{\"u}bbert and Schlenk, {Richard F} and Blau, {Igor W} and Christina Ganster and Sebastian Pfeiffer and Katayoon Shirneshan and Michael Metz and Sven Detken and J{\"o}rg Seraphin and Kathleen Jentsch-Ullrich and Angelika B{\"o}hme and Burkhard Schmidt and Lorenz Tr{\"u}mper and Detlef Haase",
note = "Copyright {\textcopyright} 2013 Elsevier Ltd. All rights reserved.",
year = "2013",
month = aug,
day = "1",
doi = "10.1016/j.leukres.2013.03.019",
language = "English",
volume = "37",
pages = "900--6",
journal = "LEUKEMIA RES",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "8",

}

RIS

TY - JOUR

T1 - Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes

T2 - first results from a prospective multicenter German diagnostic study

AU - Braulke, Friederike

AU - Jung, Klaus

AU - Schanz, Julie

AU - Götze, Katharina

AU - Müller-Thomas, Catharina

AU - Platzbecker, Uwe

AU - Germing, Ulrich

AU - Brümmendorf, Tim H

AU - Bug, Gesine

AU - Ottmann, Oliver

AU - Giagounidis, Aristoteles A N

AU - Stadler, Michael

AU - Hofmann, Wolf-Karsten

AU - Schafhausen, Philippe

AU - Lübbert, Michael

AU - Schlenk, Richard F

AU - Blau, Igor W

AU - Ganster, Christina

AU - Pfeiffer, Sebastian

AU - Shirneshan, Katayoon

AU - Metz, Michael

AU - Detken, Sven

AU - Seraphin, Jörg

AU - Jentsch-Ullrich, Kathleen

AU - Böhme, Angelika

AU - Schmidt, Burkhard

AU - Trümper, Lorenz

AU - Haase, Detlef

N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - The gold standard of cytogenetic analysis in myelodysplastic syndromes (MDS) is conventional chromosome banding (CCB) analysis of bone marrow (BM) metaphases. Most aberrations can also be detected by fluorescence-in situ-hybridization (FISH). For this prospective multicenter German diagnostic study (www.clinicaltrials.gov: #NCT01355913) 360 patients, as yet, were followed up to 3 years by sequential FISH analyses of immunomagnetically enriched CD34+ peripheral blood (PB) cells using comprehensive FISH probe panels, resulting in a total number of 19,516 FISH analyses. We demonstrate that CD34+ PB FISH correlates significantly with CCB analysis and represents a feasible method for a reliable non-invasive cytogenetic monitoring from PB.

AB - The gold standard of cytogenetic analysis in myelodysplastic syndromes (MDS) is conventional chromosome banding (CCB) analysis of bone marrow (BM) metaphases. Most aberrations can also be detected by fluorescence-in situ-hybridization (FISH). For this prospective multicenter German diagnostic study (www.clinicaltrials.gov: #NCT01355913) 360 patients, as yet, were followed up to 3 years by sequential FISH analyses of immunomagnetically enriched CD34+ peripheral blood (PB) cells using comprehensive FISH probe panels, resulting in a total number of 19,516 FISH analyses. We demonstrate that CD34+ PB FISH correlates significantly with CCB analysis and represents a feasible method for a reliable non-invasive cytogenetic monitoring from PB.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antigens, CD34

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Azacitidine

KW - Chromosome Aberrations

KW - Chromosome Banding

KW - Female

KW - Follow-Up Studies

KW - Germany

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Male

KW - Middle Aged

KW - Myelodysplastic Syndromes

KW - Prospective Studies

KW - Thalidomide

KW - Time Factors

KW - Treatment Outcome

U2 - 10.1016/j.leukres.2013.03.019

DO - 10.1016/j.leukres.2013.03.019

M3 - SCORING: Journal article

C2 - 23623559

VL - 37

SP - 900

EP - 906

JO - LEUKEMIA RES

JF - LEUKEMIA RES

SN - 0145-2126

IS - 8

ER -