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Molecular Basis of the Receptor Interactions of Polysialic Acid (polySia), polySia Mimetics, and Sulfated Polysaccharides

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Molecular Basis of the Receptor Interactions of Polysialic Acid (polySia), polySia Mimetics, and Sulfated Polysaccharides. / Zhang, Ruiyan; Loers, Gabriele; Schachner, Melitta; Boelens, Rolf; Wienk, Hans; Siebert, Simone; Eckert, Thomas; Kraan, Stefan; Rojas-Macias, Miguel A; Lütteke, Thomas; Galuska, Sebastian P; Scheidig, Axel; Petridis, Athanasios K; Liang, Songping; Billeter, Martin; Schauer, Roland; Steinmeyer, Jürgen; Schröder, Jens-Michael; Siebert, Hans-Christian.

In: CHEMMEDCHEM, Vol. 11, No. 9, 06.05.2016, p. 990-1002.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zhang, R, Loers, G, Schachner, M, Boelens, R, Wienk, H, Siebert, S, Eckert, T, Kraan, S, Rojas-Macias, MA, Lütteke, T, Galuska, SP, Scheidig, A, Petridis, AK, Liang, S, Billeter, M, Schauer, R, Steinmeyer, J, Schröder, J-M & Siebert, H-C 2016, 'Molecular Basis of the Receptor Interactions of Polysialic Acid (polySia), polySia Mimetics, and Sulfated Polysaccharides', CHEMMEDCHEM, vol. 11, no. 9, pp. 990-1002. https://doi.org/doi: 10.1002/cmdc.201500609

APA

Zhang, R., Loers, G., Schachner, M., Boelens, R., Wienk, H., Siebert, S., Eckert, T., Kraan, S., Rojas-Macias, M. A., Lütteke, T., Galuska, S. P., Scheidig, A., Petridis, A. K., Liang, S., Billeter, M., Schauer, R., Steinmeyer, J., Schröder, J-M., & Siebert, H-C. (2016). Molecular Basis of the Receptor Interactions of Polysialic Acid (polySia), polySia Mimetics, and Sulfated Polysaccharides. CHEMMEDCHEM, 11(9), 990-1002. https://doi.org/doi: 10.1002/cmdc.201500609

Vancouver

Zhang R, Loers G, Schachner M, Boelens R, Wienk H, Siebert S et al. Molecular Basis of the Receptor Interactions of Polysialic Acid (polySia), polySia Mimetics, and Sulfated Polysaccharides. CHEMMEDCHEM. 2016 May 6;11(9):990-1002. https://doi.org/doi: 10.1002/cmdc.201500609

Bibtex

@article{d767e6a3839c4ee897c9628c3cda7401,
title = "Molecular Basis of the Receptor Interactions of Polysialic Acid (polySia), polySia Mimetics, and Sulfated Polysaccharides",
abstract = "Polysialic acid (polySia) and polySia glycomimetic molecules support nerve cell regeneration, differentiation, and neuronal plasticity. With a combination of biophysical and biochemical methods, as well as data mining and molecular modeling techniques, it is possible to correlate specific ligand-receptor interactions with biochemical processes and in vivo studies that focus on the potential therapeutic impact of polySia, polySia glycomimetics, and sulfated polysaccharides in neuronal diseases. With this strategy, the receptor interactions of polySia and polySia mimetics can be understood on a submolecular level. As the HNK-1 glycan also enhances neuronal functions, we tested whether similar sulfated oligo- and polysaccharides from seaweed could be suitable, in addition to polySia, for finding potential new routes into patient care focusing on an improved cure for various neuronal diseases. The knowledge obtained here on the structural interplay between polySia or sulfated polysaccharides and their receptors can be exploited to develop new drugs and application routes for the treatment of neurological diseases and dysfunctions.",
author = "Ruiyan Zhang and Gabriele Loers and Melitta Schachner and Rolf Boelens and Hans Wienk and Simone Siebert and Thomas Eckert and Stefan Kraan and Rojas-Macias, {Miguel A} and Thomas L{\"u}tteke and Galuska, {Sebastian P} and Axel Scheidig and Petridis, {Athanasios K} and Songping Liang and Martin Billeter and Roland Schauer and J{\"u}rgen Steinmeyer and Jens-Michael Schr{\"o}der and Hans-Christian Siebert",
year = "2016",
month = may,
day = "6",
doi = "doi: 10.1002/cmdc.201500609",
language = "English",
volume = "11",
pages = "990--1002",
journal = "CHEMMEDCHEM",
issn = "1860-7179",
publisher = "John Wiley and Sons Ltd",
number = "9",

}

RIS

TY - JOUR

T1 - Molecular Basis of the Receptor Interactions of Polysialic Acid (polySia), polySia Mimetics, and Sulfated Polysaccharides

AU - Zhang, Ruiyan

AU - Loers, Gabriele

AU - Schachner, Melitta

AU - Boelens, Rolf

AU - Wienk, Hans

AU - Siebert, Simone

AU - Eckert, Thomas

AU - Kraan, Stefan

AU - Rojas-Macias, Miguel A

AU - Lütteke, Thomas

AU - Galuska, Sebastian P

AU - Scheidig, Axel

AU - Petridis, Athanasios K

AU - Liang, Songping

AU - Billeter, Martin

AU - Schauer, Roland

AU - Steinmeyer, Jürgen

AU - Schröder, Jens-Michael

AU - Siebert, Hans-Christian

PY - 2016/5/6

Y1 - 2016/5/6

N2 - Polysialic acid (polySia) and polySia glycomimetic molecules support nerve cell regeneration, differentiation, and neuronal plasticity. With a combination of biophysical and biochemical methods, as well as data mining and molecular modeling techniques, it is possible to correlate specific ligand-receptor interactions with biochemical processes and in vivo studies that focus on the potential therapeutic impact of polySia, polySia glycomimetics, and sulfated polysaccharides in neuronal diseases. With this strategy, the receptor interactions of polySia and polySia mimetics can be understood on a submolecular level. As the HNK-1 glycan also enhances neuronal functions, we tested whether similar sulfated oligo- and polysaccharides from seaweed could be suitable, in addition to polySia, for finding potential new routes into patient care focusing on an improved cure for various neuronal diseases. The knowledge obtained here on the structural interplay between polySia or sulfated polysaccharides and their receptors can be exploited to develop new drugs and application routes for the treatment of neurological diseases and dysfunctions.

AB - Polysialic acid (polySia) and polySia glycomimetic molecules support nerve cell regeneration, differentiation, and neuronal plasticity. With a combination of biophysical and biochemical methods, as well as data mining and molecular modeling techniques, it is possible to correlate specific ligand-receptor interactions with biochemical processes and in vivo studies that focus on the potential therapeutic impact of polySia, polySia glycomimetics, and sulfated polysaccharides in neuronal diseases. With this strategy, the receptor interactions of polySia and polySia mimetics can be understood on a submolecular level. As the HNK-1 glycan also enhances neuronal functions, we tested whether similar sulfated oligo- and polysaccharides from seaweed could be suitable, in addition to polySia, for finding potential new routes into patient care focusing on an improved cure for various neuronal diseases. The knowledge obtained here on the structural interplay between polySia or sulfated polysaccharides and their receptors can be exploited to develop new drugs and application routes for the treatment of neurological diseases and dysfunctions.

U2 - doi: 10.1002/cmdc.201500609

DO - doi: 10.1002/cmdc.201500609

M3 - SCORING: Journal article

C2 - 27136597

VL - 11

SP - 990

EP - 1002

JO - CHEMMEDCHEM

JF - CHEMMEDCHEM

SN - 1860-7179

IS - 9

ER -