Molecular Basis of the Receptor Interactions of Polysialic Acid (polySia), polySia Mimetics, and Sulfated Polysaccharides
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Molecular Basis of the Receptor Interactions of Polysialic Acid (polySia), polySia Mimetics, and Sulfated Polysaccharides. / Zhang, Ruiyan; Loers, Gabriele; Schachner, Melitta; Boelens, Rolf; Wienk, Hans; Siebert, Simone; Eckert, Thomas; Kraan, Stefan; Rojas-Macias, Miguel A; Lütteke, Thomas; Galuska, Sebastian P; Scheidig, Axel; Petridis, Athanasios K; Liang, Songping; Billeter, Martin; Schauer, Roland; Steinmeyer, Jürgen; Schröder, Jens-Michael; Siebert, Hans-Christian.
in: CHEMMEDCHEM, Jahrgang 11, Nr. 9, 06.05.2016, S. 990-1002.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Molecular Basis of the Receptor Interactions of Polysialic Acid (polySia), polySia Mimetics, and Sulfated Polysaccharides
AU - Zhang, Ruiyan
AU - Loers, Gabriele
AU - Schachner, Melitta
AU - Boelens, Rolf
AU - Wienk, Hans
AU - Siebert, Simone
AU - Eckert, Thomas
AU - Kraan, Stefan
AU - Rojas-Macias, Miguel A
AU - Lütteke, Thomas
AU - Galuska, Sebastian P
AU - Scheidig, Axel
AU - Petridis, Athanasios K
AU - Liang, Songping
AU - Billeter, Martin
AU - Schauer, Roland
AU - Steinmeyer, Jürgen
AU - Schröder, Jens-Michael
AU - Siebert, Hans-Christian
PY - 2016/5/6
Y1 - 2016/5/6
N2 - Polysialic acid (polySia) and polySia glycomimetic molecules support nerve cell regeneration, differentiation, and neuronal plasticity. With a combination of biophysical and biochemical methods, as well as data mining and molecular modeling techniques, it is possible to correlate specific ligand-receptor interactions with biochemical processes and in vivo studies that focus on the potential therapeutic impact of polySia, polySia glycomimetics, and sulfated polysaccharides in neuronal diseases. With this strategy, the receptor interactions of polySia and polySia mimetics can be understood on a submolecular level. As the HNK-1 glycan also enhances neuronal functions, we tested whether similar sulfated oligo- and polysaccharides from seaweed could be suitable, in addition to polySia, for finding potential new routes into patient care focusing on an improved cure for various neuronal diseases. The knowledge obtained here on the structural interplay between polySia or sulfated polysaccharides and their receptors can be exploited to develop new drugs and application routes for the treatment of neurological diseases and dysfunctions.
AB - Polysialic acid (polySia) and polySia glycomimetic molecules support nerve cell regeneration, differentiation, and neuronal plasticity. With a combination of biophysical and biochemical methods, as well as data mining and molecular modeling techniques, it is possible to correlate specific ligand-receptor interactions with biochemical processes and in vivo studies that focus on the potential therapeutic impact of polySia, polySia glycomimetics, and sulfated polysaccharides in neuronal diseases. With this strategy, the receptor interactions of polySia and polySia mimetics can be understood on a submolecular level. As the HNK-1 glycan also enhances neuronal functions, we tested whether similar sulfated oligo- and polysaccharides from seaweed could be suitable, in addition to polySia, for finding potential new routes into patient care focusing on an improved cure for various neuronal diseases. The knowledge obtained here on the structural interplay between polySia or sulfated polysaccharides and their receptors can be exploited to develop new drugs and application routes for the treatment of neurological diseases and dysfunctions.
U2 - doi: 10.1002/cmdc.201500609
DO - doi: 10.1002/cmdc.201500609
M3 - SCORING: Journal article
C2 - 27136597
VL - 11
SP - 990
EP - 1002
JO - CHEMMEDCHEM
JF - CHEMMEDCHEM
SN - 1860-7179
IS - 9
ER -