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Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

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Molecular and functional heterogeneity of IL-10-producing CD4+ T cells. / Brockmann, Leonie; Soukou, Shiwa; Steglich, Babett; Czarnewski, Paulo; Zhao, Lilan; Wende, Sandra; Bedke, Tanja; Ergen, Can; Manthey, Carolin; Agalioti, Theodora; Geffken, Maria; Seiz, Oliver; Parigi, Sara M; Sorini, Chiara; Geginat, Jens; Fujio, Keishi; Jacobs, Thomas; Roesch, Thomas; Izbicki, Jacob R; Lohse, Ansgar W; Flavell, Richard A; Krebs, Christian; Gustafsson, Jan-Ake; Antonson, Per; Roncarolo, Maria Grazia; Villablanca, Eduardo J; Gagliani, Nicola; Huber, Samuel.

In: NAT COMMUN, Vol. 9, No. 1, 21.12.2018, p. 5457.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Brockmann, L, Soukou, S, Steglich, B, Czarnewski, P, Zhao, L, Wende, S, Bedke, T, Ergen, C, Manthey, C, Agalioti, T, Geffken, M, Seiz, O, Parigi, SM, Sorini, C, Geginat, J, Fujio, K, Jacobs, T, Roesch, T, Izbicki, JR, Lohse, AW, Flavell, RA, Krebs, C, Gustafsson, J-A, Antonson, P, Roncarolo, MG, Villablanca, EJ, Gagliani, N & Huber, S 2018, 'Molecular and functional heterogeneity of IL-10-producing CD4+ T cells', NAT COMMUN, vol. 9, no. 1, pp. 5457. https://doi.org/10.1038/s41467-018-07581-4

APA

Brockmann, L., Soukou, S., Steglich, B., Czarnewski, P., Zhao, L., Wende, S., Bedke, T., Ergen, C., Manthey, C., Agalioti, T., Geffken, M., Seiz, O., Parigi, S. M., Sorini, C., Geginat, J., Fujio, K., Jacobs, T., Roesch, T., Izbicki, J. R., ... Huber, S. (2018). Molecular and functional heterogeneity of IL-10-producing CD4+ T cells. NAT COMMUN, 9(1), 5457. https://doi.org/10.1038/s41467-018-07581-4

Vancouver

Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S et al. Molecular and functional heterogeneity of IL-10-producing CD4+ T cells. NAT COMMUN. 2018 Dec 21;9(1):5457. https://doi.org/10.1038/s41467-018-07581-4

Bibtex

@article{d34805e9ac0c4f17bfc99b6e08a7f979,
title = "Molecular and functional heterogeneity of IL-10-producing CD4+ T cells",
abstract = "IL-10 is a prototypical anti-inflammatory cytokine, which is fundamental to the maintenance of immune homeostasis, especially in the intestine. There is an assumption that cells producing IL-10 have an immunoregulatory function. However, here we report that IL-10-producing CD4+ T cells are phenotypically and functionally heterogeneous. By combining single cell transcriptome and functional analyses, we identified a subpopulation of IL-10-producing Foxp3neg CD4+ T cells that displays regulatory activity unlike other IL-10-producing CD4+ T cells, which are unexpectedly pro-inflammatory. The combinatorial expression of co-inhibitory receptors is sufficient to discriminate IL-10-producing CD4+ T cells with regulatory function from others and to identify them across different tissues and disease models in mice and humans. These regulatory IL-10-producing Foxp3neg CD4+ T cells have a unique transcriptional program, which goes beyond the regulation of IL-10 expression. Finally, we found that patients with Inflammatory Bowel Disease demonstrate a deficiency in this specific regulatory T-cell subpopulation.",
keywords = "Journal Article",
author = "Leonie Brockmann and Shiwa Soukou and Babett Steglich and Paulo Czarnewski and Lilan Zhao and Sandra Wende and Tanja Bedke and Can Ergen and Carolin Manthey and Theodora Agalioti and Maria Geffken and Oliver Seiz and Parigi, {Sara M} and Chiara Sorini and Jens Geginat and Keishi Fujio and Thomas Jacobs and Thomas Roesch and Izbicki, {Jacob R} and Lohse, {Ansgar W} and Flavell, {Richard A} and Christian Krebs and Jan-Ake Gustafsson and Per Antonson and Roncarolo, {Maria Grazia} and Villablanca, {Eduardo J} and Nicola Gagliani and Samuel Huber",
year = "2018",
month = dec,
day = "21",
doi = "10.1038/s41467-018-07581-4",
language = "English",
volume = "9",
pages = "5457",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

AU - Brockmann, Leonie

AU - Soukou, Shiwa

AU - Steglich, Babett

AU - Czarnewski, Paulo

AU - Zhao, Lilan

AU - Wende, Sandra

AU - Bedke, Tanja

AU - Ergen, Can

AU - Manthey, Carolin

AU - Agalioti, Theodora

AU - Geffken, Maria

AU - Seiz, Oliver

AU - Parigi, Sara M

AU - Sorini, Chiara

AU - Geginat, Jens

AU - Fujio, Keishi

AU - Jacobs, Thomas

AU - Roesch, Thomas

AU - Izbicki, Jacob R

AU - Lohse, Ansgar W

AU - Flavell, Richard A

AU - Krebs, Christian

AU - Gustafsson, Jan-Ake

AU - Antonson, Per

AU - Roncarolo, Maria Grazia

AU - Villablanca, Eduardo J

AU - Gagliani, Nicola

AU - Huber, Samuel

PY - 2018/12/21

Y1 - 2018/12/21

N2 - IL-10 is a prototypical anti-inflammatory cytokine, which is fundamental to the maintenance of immune homeostasis, especially in the intestine. There is an assumption that cells producing IL-10 have an immunoregulatory function. However, here we report that IL-10-producing CD4+ T cells are phenotypically and functionally heterogeneous. By combining single cell transcriptome and functional analyses, we identified a subpopulation of IL-10-producing Foxp3neg CD4+ T cells that displays regulatory activity unlike other IL-10-producing CD4+ T cells, which are unexpectedly pro-inflammatory. The combinatorial expression of co-inhibitory receptors is sufficient to discriminate IL-10-producing CD4+ T cells with regulatory function from others and to identify them across different tissues and disease models in mice and humans. These regulatory IL-10-producing Foxp3neg CD4+ T cells have a unique transcriptional program, which goes beyond the regulation of IL-10 expression. Finally, we found that patients with Inflammatory Bowel Disease demonstrate a deficiency in this specific regulatory T-cell subpopulation.

AB - IL-10 is a prototypical anti-inflammatory cytokine, which is fundamental to the maintenance of immune homeostasis, especially in the intestine. There is an assumption that cells producing IL-10 have an immunoregulatory function. However, here we report that IL-10-producing CD4+ T cells are phenotypically and functionally heterogeneous. By combining single cell transcriptome and functional analyses, we identified a subpopulation of IL-10-producing Foxp3neg CD4+ T cells that displays regulatory activity unlike other IL-10-producing CD4+ T cells, which are unexpectedly pro-inflammatory. The combinatorial expression of co-inhibitory receptors is sufficient to discriminate IL-10-producing CD4+ T cells with regulatory function from others and to identify them across different tissues and disease models in mice and humans. These regulatory IL-10-producing Foxp3neg CD4+ T cells have a unique transcriptional program, which goes beyond the regulation of IL-10 expression. Finally, we found that patients with Inflammatory Bowel Disease demonstrate a deficiency in this specific regulatory T-cell subpopulation.

KW - Journal Article

U2 - 10.1038/s41467-018-07581-4

DO - 10.1038/s41467-018-07581-4

M3 - SCORING: Journal article

C2 - 30575716

VL - 9

SP - 5457

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -