Modulating ion channel function with antibodies and nanobodies

Catelijne Stortelers; Carolina Pinto-Espinoza; Diane Van Hoorick; Friedrich Koch-Nolte

doi:10.1016/j.coi.2018.02.003

Modulating ion channel function with antibodies and nanobodies

Standard

Modulating ion channel function with antibodies and nanobodies. / Stortelers, Catelijne; Pinto-Espinoza, Carolina; Van Hoorick, Diane; Koch-Nolte, Friedrich.

In: CURR OPIN IMMUNOL, Vol. 52, 06.2018, p. 18-26.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Stortelers, C, Pinto-Espinoza, C, Van Hoorick, D & Koch-Nolte, F 2018, 'Modulating ion channel function with antibodies and nanobodies', CURR OPIN IMMUNOL, vol. 52, pp. 18-26. https://doi.org/10.1016/j.coi.2018.02.003

APA

Stortelers, C., Pinto-Espinoza, C., Van Hoorick, D., & Koch-Nolte, F. (2018). Modulating ion channel function with antibodies and nanobodies. CURR OPIN IMMUNOL, 52, 18-26. https://doi.org/10.1016/j.coi.2018.02.003

Vancouver

Stortelers C, Pinto-Espinoza C, Van Hoorick D, Koch-Nolte F. Modulating ion channel function with antibodies and nanobodies. CURR OPIN IMMUNOL. 2018 Jun;52:18-26. https://doi.org/10.1016/j.coi.2018.02.003

Bibtex

@article{99304644341f44ad8fdb1a2d2541d060,

title = "Modulating ion channel function with antibodies and nanobodies",

abstract = "Immune cells express various voltage-gated and ligand-gated ion channels that mediate the influx and efflux of charged ions across the plasma membrane, thereby controlling the membrane potential and mediating intracellular signal transduction pathways. These channels thus present potential targets for experimental modulation of immune responses and for therapeutic interventions in immune disease. Small molecule drugs and natural toxins acting on ion channels have illustrated the potential therapeutic benefit of targeting ion channels on immune cells. Unwanted side effects and immunogenicity have however hampered the application of these molecules. Owing to their high specificity, low immunogenicity and beneficial pharmacodynamics, antibodies targeting membrane and secretory proteins have emerged as potent therapeutics in oncology and inflammation. Nanobodies-single domain fragments derived from heavy chain antibodies naturally occurring in camelids-offer additional benefits versus antibodies, including protrusion into cryptic epitopes and easy formatting of multi-specific reagents. Here we review recent progress in the development and application of antibodies and Nanobodies targeting ion channels on immune cells.",

keywords = "Journal Article, Review, Research Support, Non-U.S. Gov't",

author = "Catelijne Stortelers and Carolina Pinto-Espinoza and {Van Hoorick}, Diane and Friedrich Koch-Nolte",

note = "Copyright {\textcopyright} 2018. Published by Elsevier Ltd.",

year = "2018",

month = jun,

doi = "10.1016/j.coi.2018.02.003",

language = "English",

volume = "52",

pages = "18--26",

}

RIS

TY - JOUR

T1 - Modulating ion channel function with antibodies and nanobodies

AU - Stortelers, Catelijne

AU - Pinto-Espinoza, Carolina

AU - Van Hoorick, Diane

AU - Koch-Nolte, Friedrich

PY - 2018/6

Y1 - 2018/6

N2 - Immune cells express various voltage-gated and ligand-gated ion channels that mediate the influx and efflux of charged ions across the plasma membrane, thereby controlling the membrane potential and mediating intracellular signal transduction pathways. These channels thus present potential targets for experimental modulation of immune responses and for therapeutic interventions in immune disease. Small molecule drugs and natural toxins acting on ion channels have illustrated the potential therapeutic benefit of targeting ion channels on immune cells. Unwanted side effects and immunogenicity have however hampered the application of these molecules. Owing to their high specificity, low immunogenicity and beneficial pharmacodynamics, antibodies targeting membrane and secretory proteins have emerged as potent therapeutics in oncology and inflammation. Nanobodies-single domain fragments derived from heavy chain antibodies naturally occurring in camelids-offer additional benefits versus antibodies, including protrusion into cryptic epitopes and easy formatting of multi-specific reagents. Here we review recent progress in the development and application of antibodies and Nanobodies targeting ion channels on immune cells.

AB - Immune cells express various voltage-gated and ligand-gated ion channels that mediate the influx and efflux of charged ions across the plasma membrane, thereby controlling the membrane potential and mediating intracellular signal transduction pathways. These channels thus present potential targets for experimental modulation of immune responses and for therapeutic interventions in immune disease. Small molecule drugs and natural toxins acting on ion channels have illustrated the potential therapeutic benefit of targeting ion channels on immune cells. Unwanted side effects and immunogenicity have however hampered the application of these molecules. Owing to their high specificity, low immunogenicity and beneficial pharmacodynamics, antibodies targeting membrane and secretory proteins have emerged as potent therapeutics in oncology and inflammation. Nanobodies-single domain fragments derived from heavy chain antibodies naturally occurring in camelids-offer additional benefits versus antibodies, including protrusion into cryptic epitopes and easy formatting of multi-specific reagents. Here we review recent progress in the development and application of antibodies and Nanobodies targeting ion channels on immune cells.

KW - Journal Article

KW - Review

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.coi.2018.02.003

DO - 10.1016/j.coi.2018.02.003

M3 - SCORING: Review article

C2 - 29579624

VL - 52

SP - 18

EP - 26

ER -