Modulating ion channel function with antibodies and nanobodies
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Modulating ion channel function with antibodies and nanobodies. / Stortelers, Catelijne; Pinto-Espinoza, Carolina; Van Hoorick, Diane; Koch-Nolte, Friedrich.
in: CURR OPIN IMMUNOL, Jahrgang 52, 06.2018, S. 18-26.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Modulating ion channel function with antibodies and nanobodies
AU - Stortelers, Catelijne
AU - Pinto-Espinoza, Carolina
AU - Van Hoorick, Diane
AU - Koch-Nolte, Friedrich
N1 - Copyright © 2018. Published by Elsevier Ltd.
PY - 2018/6
Y1 - 2018/6
N2 - Immune cells express various voltage-gated and ligand-gated ion channels that mediate the influx and efflux of charged ions across the plasma membrane, thereby controlling the membrane potential and mediating intracellular signal transduction pathways. These channels thus present potential targets for experimental modulation of immune responses and for therapeutic interventions in immune disease. Small molecule drugs and natural toxins acting on ion channels have illustrated the potential therapeutic benefit of targeting ion channels on immune cells. Unwanted side effects and immunogenicity have however hampered the application of these molecules. Owing to their high specificity, low immunogenicity and beneficial pharmacodynamics, antibodies targeting membrane and secretory proteins have emerged as potent therapeutics in oncology and inflammation. Nanobodies-single domain fragments derived from heavy chain antibodies naturally occurring in camelids-offer additional benefits versus antibodies, including protrusion into cryptic epitopes and easy formatting of multi-specific reagents. Here we review recent progress in the development and application of antibodies and Nanobodies targeting ion channels on immune cells.
AB - Immune cells express various voltage-gated and ligand-gated ion channels that mediate the influx and efflux of charged ions across the plasma membrane, thereby controlling the membrane potential and mediating intracellular signal transduction pathways. These channels thus present potential targets for experimental modulation of immune responses and for therapeutic interventions in immune disease. Small molecule drugs and natural toxins acting on ion channels have illustrated the potential therapeutic benefit of targeting ion channels on immune cells. Unwanted side effects and immunogenicity have however hampered the application of these molecules. Owing to their high specificity, low immunogenicity and beneficial pharmacodynamics, antibodies targeting membrane and secretory proteins have emerged as potent therapeutics in oncology and inflammation. Nanobodies-single domain fragments derived from heavy chain antibodies naturally occurring in camelids-offer additional benefits versus antibodies, including protrusion into cryptic epitopes and easy formatting of multi-specific reagents. Here we review recent progress in the development and application of antibodies and Nanobodies targeting ion channels on immune cells.
KW - Journal Article
KW - Review
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.coi.2018.02.003
DO - 10.1016/j.coi.2018.02.003
M3 - SCORING: Review article
C2 - 29579624
VL - 52
SP - 18
EP - 26
ER -