Modelling epidermal homeostasis as an approach for clinical bioinformatics.
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Modelling epidermal homeostasis as an approach for clinical bioinformatics. / Grabe, Niels; Pommerencke, Thora; Müller, Dennis; Huber, Simone; Neuber, Karsten; Dickhaus, Hartmut.
In: Stud Health Technol Inform, Vol. 124, 2006, p. 105-110.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Modelling epidermal homeostasis as an approach for clinical bioinformatics.
AU - Grabe, Niels
AU - Pommerencke, Thora
AU - Müller, Dennis
AU - Huber, Simone
AU - Neuber, Karsten
AU - Dickhaus, Hartmut
PY - 2006
Y1 - 2006
N2 - Modelling in systems biology currently lacks clinical applications. As a possible approach leading to clinical relevance the modelling of tissue homeostasis is proposed. As an example a model of epidermal homeostasis is presented which reproduces central morphological and kinetic characteristics of epidermal tissue. Each individual cell is modelled as an agent. The tissue arises as an emergent phenomenon from the interactions of agents. Each agent's behaviour is qualitatively modelled by a simple differentiation state-flow program. Epithelialisation under the influence of parameters concerning stem-cell location is briefly demonstrated.
AB - Modelling in systems biology currently lacks clinical applications. As a possible approach leading to clinical relevance the modelling of tissue homeostasis is proposed. As an example a model of epidermal homeostasis is presented which reproduces central morphological and kinetic characteristics of epidermal tissue. Each individual cell is modelled as an agent. The tissue arises as an emergent phenomenon from the interactions of agents. Each agent's behaviour is qualitatively modelled by a simple differentiation state-flow program. Epithelialisation under the influence of parameters concerning stem-cell location is briefly demonstrated.
M3 - SCORING: Zeitschriftenaufsatz
VL - 124
SP - 105
EP - 110
ER -