Mitogenic toxins as MHC class II-dependent probes for T cell antigen receptors
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Mitogenic toxins as MHC class II-dependent probes for T cell antigen receptors. / Fleischer, B; Mittrücker, H W; Metzroth, B; Braun, M; Hartwig, U.
In: Behring Institute Mitteilungen, No. 88, 01.02.1991, p. 170-6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Mitogenic toxins as MHC class II-dependent probes for T cell antigen receptors
AU - Fleischer, B
AU - Mittrücker, H W
AU - Metzroth, B
AU - Braun, M
AU - Hartwig, U
PY - 1991/2/1
Y1 - 1991/2/1
N2 - The enterotoxins produced by Staphylococcus aureus (SE) are prototypes of a group of microbial exoproteins that share a potent mitogenic activity for T lymphocytes of several species. These exoproteins use a very effective novel mechanism of T lymphocyte stimulation. For stimulation of all types of T cells (CD4+, CD8+ as well as gamma delta TCR+) the presence of allogeneic or xenogeneic MHC class II molecules on accessory or target cells is required. This requirement is reflected by a selective binding of the toxins to MHC class II molecules. The toxins stimulate preferentially but not exclusively alpha beta TCR+ T cells carrying certain TCR V beta s. A current model suggests that the toxins are functionally bivalent molecules, crosslinking variable parts of the TCR with MHC class II molecules on the accessory or target cells. Of all T cell mitogens the toxins thus most closely simulate T cell recognition of specific antigen. The differential pattern of reactivity of human and murine T cells with various toxins suggests that the toxins have been adapted to the host's immune system in evolution.
AB - The enterotoxins produced by Staphylococcus aureus (SE) are prototypes of a group of microbial exoproteins that share a potent mitogenic activity for T lymphocytes of several species. These exoproteins use a very effective novel mechanism of T lymphocyte stimulation. For stimulation of all types of T cells (CD4+, CD8+ as well as gamma delta TCR+) the presence of allogeneic or xenogeneic MHC class II molecules on accessory or target cells is required. This requirement is reflected by a selective binding of the toxins to MHC class II molecules. The toxins stimulate preferentially but not exclusively alpha beta TCR+ T cells carrying certain TCR V beta s. A current model suggests that the toxins are functionally bivalent molecules, crosslinking variable parts of the TCR with MHC class II molecules on the accessory or target cells. Of all T cell mitogens the toxins thus most closely simulate T cell recognition of specific antigen. The differential pattern of reactivity of human and murine T cells with various toxins suggests that the toxins have been adapted to the host's immune system in evolution.
KW - Enterotoxins
KW - Histocompatibility Antigens Class II
KW - Humans
KW - Lymphocyte Activation
KW - Mitogens
KW - Receptors, Antigen, T-Cell
KW - Staphylococcus aureus
KW - T-Lymphocytes
M3 - SCORING: Journal article
C2 - 2049035
SP - 170
EP - 176
IS - 88
ER -