PortalPublikationenMitogenic toxins as MHC class II-dependent probes for T cell...

Mitogenic toxins as MHC class II-dependent probes for T cell antigen receptors

Standard

Mitogenic toxins as MHC class II-dependent probes for T cell antigen receptors. / Fleischer, B; Mittrücker, H W; Metzroth, B; Braun, M; Hartwig, U.

in: Behring Institute Mitteilungen, Nr. 88, 01.02.1991, S. 170-6.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fleischer, B, Mittrücker, HW, Metzroth, B, Braun, M & Hartwig, U 1991, 'Mitogenic toxins as MHC class II-dependent probes for T cell antigen receptors', Behring Institute Mitteilungen, Nr. 88, S. 170-6.

APA

Fleischer, B., Mittrücker, H. W., Metzroth, B., Braun, M., & Hartwig, U. (1991). Mitogenic toxins as MHC class II-dependent probes for T cell antigen receptors. Behring Institute Mitteilungen, (88), 170-6.

Vancouver

Fleischer B, Mittrücker HW, Metzroth B, Braun M, Hartwig U. Mitogenic toxins as MHC class II-dependent probes for T cell antigen receptors. Behring Institute Mitteilungen. 1991 Feb 1;(88):170-6.

Bibtex

@article{0a805aee63cf46afa7d2689f24d3faff,
title = "Mitogenic toxins as MHC class II-dependent probes for T cell antigen receptors",
abstract = "The enterotoxins produced by Staphylococcus aureus (SE) are prototypes of a group of microbial exoproteins that share a potent mitogenic activity for T lymphocytes of several species. These exoproteins use a very effective novel mechanism of T lymphocyte stimulation. For stimulation of all types of T cells (CD4+, CD8+ as well as gamma delta TCR+) the presence of allogeneic or xenogeneic MHC class II molecules on accessory or target cells is required. This requirement is reflected by a selective binding of the toxins to MHC class II molecules. The toxins stimulate preferentially but not exclusively alpha beta TCR+ T cells carrying certain TCR V beta s. A current model suggests that the toxins are functionally bivalent molecules, crosslinking variable parts of the TCR with MHC class II molecules on the accessory or target cells. Of all T cell mitogens the toxins thus most closely simulate T cell recognition of specific antigen. The differential pattern of reactivity of human and murine T cells with various toxins suggests that the toxins have been adapted to the host's immune system in evolution.",
keywords = "Enterotoxins, Histocompatibility Antigens Class II, Humans, Lymphocyte Activation, Mitogens, Receptors, Antigen, T-Cell, Staphylococcus aureus, T-Lymphocytes",
author = "B Fleischer and Mittr{\"u}cker, {H W} and B Metzroth and M Braun and U Hartwig",
year = "1991",
month = feb,
day = "1",
language = "English",
pages = "170--6",
number = "88",

}

RIS

TY - JOUR

T1 - Mitogenic toxins as MHC class II-dependent probes for T cell antigen receptors

AU - Fleischer, B

AU - Mittrücker, H W

AU - Metzroth, B

AU - Braun, M

AU - Hartwig, U

PY - 1991/2/1

Y1 - 1991/2/1

N2 - The enterotoxins produced by Staphylococcus aureus (SE) are prototypes of a group of microbial exoproteins that share a potent mitogenic activity for T lymphocytes of several species. These exoproteins use a very effective novel mechanism of T lymphocyte stimulation. For stimulation of all types of T cells (CD4+, CD8+ as well as gamma delta TCR+) the presence of allogeneic or xenogeneic MHC class II molecules on accessory or target cells is required. This requirement is reflected by a selective binding of the toxins to MHC class II molecules. The toxins stimulate preferentially but not exclusively alpha beta TCR+ T cells carrying certain TCR V beta s. A current model suggests that the toxins are functionally bivalent molecules, crosslinking variable parts of the TCR with MHC class II molecules on the accessory or target cells. Of all T cell mitogens the toxins thus most closely simulate T cell recognition of specific antigen. The differential pattern of reactivity of human and murine T cells with various toxins suggests that the toxins have been adapted to the host's immune system in evolution.

AB - The enterotoxins produced by Staphylococcus aureus (SE) are prototypes of a group of microbial exoproteins that share a potent mitogenic activity for T lymphocytes of several species. These exoproteins use a very effective novel mechanism of T lymphocyte stimulation. For stimulation of all types of T cells (CD4+, CD8+ as well as gamma delta TCR+) the presence of allogeneic or xenogeneic MHC class II molecules on accessory or target cells is required. This requirement is reflected by a selective binding of the toxins to MHC class II molecules. The toxins stimulate preferentially but not exclusively alpha beta TCR+ T cells carrying certain TCR V beta s. A current model suggests that the toxins are functionally bivalent molecules, crosslinking variable parts of the TCR with MHC class II molecules on the accessory or target cells. Of all T cell mitogens the toxins thus most closely simulate T cell recognition of specific antigen. The differential pattern of reactivity of human and murine T cells with various toxins suggests that the toxins have been adapted to the host's immune system in evolution.

KW - Enterotoxins

KW - Histocompatibility Antigens Class II

KW - Humans

KW - Lymphocyte Activation

KW - Mitogens

KW - Receptors, Antigen, T-Cell

KW - Staphylococcus aureus

KW - T-Lymphocytes

M3 - SCORING: Journal article

C2 - 2049035

SP - 170

EP - 176

IS - 88

ER -