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Missing in action-The meaning of cell death in tissue damage and inflammation

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Missing in action-The meaning of cell death in tissue damage and inflammation. / Muñoz, Luis E; Leppkes, Moritz; Fuchs, Tobias A; Hoffmann, Markus; Herrmann, Martin.

In: IMMUNOL REV, Vol. 280, No. 1, 11.2017, p. 26-40.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Muñoz, LE, Leppkes, M, Fuchs, TA, Hoffmann, M & Herrmann, M 2017, 'Missing in action-The meaning of cell death in tissue damage and inflammation', IMMUNOL REV, vol. 280, no. 1, pp. 26-40. https://doi.org/10.1111/imr.12569

APA

Muñoz, L. E., Leppkes, M., Fuchs, T. A., Hoffmann, M., & Herrmann, M. (2017). Missing in action-The meaning of cell death in tissue damage and inflammation. IMMUNOL REV, 280(1), 26-40. https://doi.org/10.1111/imr.12569

Vancouver

Muñoz LE, Leppkes M, Fuchs TA, Hoffmann M, Herrmann M. Missing in action-The meaning of cell death in tissue damage and inflammation. IMMUNOL REV. 2017 Nov;280(1):26-40. https://doi.org/10.1111/imr.12569

Bibtex

@article{2e1b228e67e14351a86746c501725a3b,
title = "Missing in action-The meaning of cell death in tissue damage and inflammation",
abstract = "Billions of cells die every day in higher organisms as part of the normal process of tissue homeostasis. During special conditions like in development, acute infections, mechanical injuries, and immunity, cell death is a common denominator and it exerts profound effects in the outcome of these scenarios. To prevent the accumulation of aged, superfluous, infected, damaged and dead cells, professional phagocytes act in a rapid and efficient manner to clear the battle field and avoid spread of the destruction. Neutrophils are the most abundant effector immune cells that extravasate into tissues and can turn injured tissues into gory battle fields. In peace times, neutrophils tend to patrol tissues without provoking inflammatory reactions. We discuss in this review actual and forgotten knowledge about the meaning of cell death during homeostatic processes and drive the attention to the importance of the action of neutrophils during patrolling and for the maintenance or recovery of the homeostatic state once the organism gets attacked or injured, respectively. In this fashion, we disclose several disease conditions that arise as collateral damage of physiological responses to death.",
keywords = "Journal Article, Review",
author = "Mu{\~n}oz, {Luis E} and Moritz Leppkes and Fuchs, {Tobias A} and Markus Hoffmann and Martin Herrmann",
note = "{\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2017",
month = nov,
doi = "10.1111/imr.12569",
language = "English",
volume = "280",
pages = "26--40",
journal = "IMMUNOL REV",
issn = "0105-2896",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Missing in action-The meaning of cell death in tissue damage and inflammation

AU - Muñoz, Luis E

AU - Leppkes, Moritz

AU - Fuchs, Tobias A

AU - Hoffmann, Markus

AU - Herrmann, Martin

N1 - © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2017/11

Y1 - 2017/11

N2 - Billions of cells die every day in higher organisms as part of the normal process of tissue homeostasis. During special conditions like in development, acute infections, mechanical injuries, and immunity, cell death is a common denominator and it exerts profound effects in the outcome of these scenarios. To prevent the accumulation of aged, superfluous, infected, damaged and dead cells, professional phagocytes act in a rapid and efficient manner to clear the battle field and avoid spread of the destruction. Neutrophils are the most abundant effector immune cells that extravasate into tissues and can turn injured tissues into gory battle fields. In peace times, neutrophils tend to patrol tissues without provoking inflammatory reactions. We discuss in this review actual and forgotten knowledge about the meaning of cell death during homeostatic processes and drive the attention to the importance of the action of neutrophils during patrolling and for the maintenance or recovery of the homeostatic state once the organism gets attacked or injured, respectively. In this fashion, we disclose several disease conditions that arise as collateral damage of physiological responses to death.

AB - Billions of cells die every day in higher organisms as part of the normal process of tissue homeostasis. During special conditions like in development, acute infections, mechanical injuries, and immunity, cell death is a common denominator and it exerts profound effects in the outcome of these scenarios. To prevent the accumulation of aged, superfluous, infected, damaged and dead cells, professional phagocytes act in a rapid and efficient manner to clear the battle field and avoid spread of the destruction. Neutrophils are the most abundant effector immune cells that extravasate into tissues and can turn injured tissues into gory battle fields. In peace times, neutrophils tend to patrol tissues without provoking inflammatory reactions. We discuss in this review actual and forgotten knowledge about the meaning of cell death during homeostatic processes and drive the attention to the importance of the action of neutrophils during patrolling and for the maintenance or recovery of the homeostatic state once the organism gets attacked or injured, respectively. In this fashion, we disclose several disease conditions that arise as collateral damage of physiological responses to death.

KW - Journal Article

KW - Review

U2 - 10.1111/imr.12569

DO - 10.1111/imr.12569

M3 - SCORING: Review article

C2 - 29027227

VL - 280

SP - 26

EP - 40

JO - IMMUNOL REV

JF - IMMUNOL REV

SN - 0105-2896

IS - 1

ER -