Missing in action-The meaning of cell death in tissue damage and inflammation
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Missing in action-The meaning of cell death in tissue damage and inflammation. / Muñoz, Luis E; Leppkes, Moritz; Fuchs, Tobias A; Hoffmann, Markus; Herrmann, Martin.
in: IMMUNOL REV, Jahrgang 280, Nr. 1, 11.2017, S. 26-40.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Missing in action-The meaning of cell death in tissue damage and inflammation
AU - Muñoz, Luis E
AU - Leppkes, Moritz
AU - Fuchs, Tobias A
AU - Hoffmann, Markus
AU - Herrmann, Martin
N1 - © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2017/11
Y1 - 2017/11
N2 - Billions of cells die every day in higher organisms as part of the normal process of tissue homeostasis. During special conditions like in development, acute infections, mechanical injuries, and immunity, cell death is a common denominator and it exerts profound effects in the outcome of these scenarios. To prevent the accumulation of aged, superfluous, infected, damaged and dead cells, professional phagocytes act in a rapid and efficient manner to clear the battle field and avoid spread of the destruction. Neutrophils are the most abundant effector immune cells that extravasate into tissues and can turn injured tissues into gory battle fields. In peace times, neutrophils tend to patrol tissues without provoking inflammatory reactions. We discuss in this review actual and forgotten knowledge about the meaning of cell death during homeostatic processes and drive the attention to the importance of the action of neutrophils during patrolling and for the maintenance or recovery of the homeostatic state once the organism gets attacked or injured, respectively. In this fashion, we disclose several disease conditions that arise as collateral damage of physiological responses to death.
AB - Billions of cells die every day in higher organisms as part of the normal process of tissue homeostasis. During special conditions like in development, acute infections, mechanical injuries, and immunity, cell death is a common denominator and it exerts profound effects in the outcome of these scenarios. To prevent the accumulation of aged, superfluous, infected, damaged and dead cells, professional phagocytes act in a rapid and efficient manner to clear the battle field and avoid spread of the destruction. Neutrophils are the most abundant effector immune cells that extravasate into tissues and can turn injured tissues into gory battle fields. In peace times, neutrophils tend to patrol tissues without provoking inflammatory reactions. We discuss in this review actual and forgotten knowledge about the meaning of cell death during homeostatic processes and drive the attention to the importance of the action of neutrophils during patrolling and for the maintenance or recovery of the homeostatic state once the organism gets attacked or injured, respectively. In this fashion, we disclose several disease conditions that arise as collateral damage of physiological responses to death.
KW - Journal Article
KW - Review
U2 - 10.1111/imr.12569
DO - 10.1111/imr.12569
M3 - SCORING: Review article
C2 - 29027227
VL - 280
SP - 26
EP - 40
JO - IMMUNOL REV
JF - IMMUNOL REV
SN - 0105-2896
IS - 1
ER -